SNX4 Gene

HGNC Family	Sorting nexins (SNX)
Name	sorting nexin 4
Description	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSorting nexin‑4 (SNX4) is a member of the SNX‐BAR protein sub‐family that associates with tubular and vesicular membranes of early endosomes and the endocytic recycling compartment via its phosphoinositide (PX) and Bin‑Amphiphysin‑Rvs (BAR) domains. Multiple studies demonstrate that SNX4 is crucial for the iterative, geometry‑based sorting of cargos such as the transferrin receptor (TfnR) by driving membrane tubulation, which facilitates long‑range transport between early endosomes and recycling compartments. This activity has been mapped to its dynamic localization on peripheral endosomal subdomains and its regulation during transitions marked by small Rab GTPases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSNX4 also participates in coordinating endocytic and post‐endocytic trafficking by interacting with regulatory proteins. For example, its binding to amphiphysin 2 and α‑taxilin—as well as its association with proteins such as KIBRA that bridge it to the microtubule motor dynein—underscores its role in coupling membrane deformation with motor‑driven transport. Moreover, modulation of SNX4 levels (or sequestration of its interacting partners) can perturb the recycling of key receptors, leading to their lysosomal degradation, and affect retrograde transport processes that depend on phosphatidylinositol 3‑kinase (PI3K) and its product PI(3)P."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its classical role in receptor recycling, SNX4 is implicated in broader trafficking routes including endosome‑to‑Golgi transport and the recycling of autophagy‐related proteins. Notably, SNX4 mediates the retrieval of ATG9A from endolysosomes to early endosomes—a process critical for maintaining autophagic flux—while emerging evidence also suggests that aberrant SNX4‑mediated trafficking may influence pathways relevant to Alzheimer’s disease. These findings indicate that SNX4 functions as a versatile regulator coordinating membrane remodeling, cargo sorting, and long‐distance vesicular transport across multiple intracellular pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Colin J Traer, Anna C Rutherford, Krysten J Palmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1656"}], "href": "https://doi.org/10.1038/ncb1656"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17994011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17994011"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jan R T van Weering, Paul Verkade, Peter J Cullen "}, {"type": "b", "children": [{"type": "t", "text": "SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2011.01297.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2011.01297.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21973056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21973056"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Corinne Leprince, Erwan Le Scolan, Brigitte Meunier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.00403"}], "href": "https://doi.org/10.1242/jcs.00403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12668730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12668730"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sigrid S Skånland, Sébastien Wälchli, Audrun Utskarpen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2006.00527.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2006.00527.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17319803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17319803"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hiroshi Sakane, Yukimi Horii, Satoru Nogami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0093509"}], "href": "https://doi.org/10.1371/journal.pone.0093509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24690921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24690921"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sigrid S Skånland, Sébastien Wälchli, Andreas Brech, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNX4 in complex with clathrin and dynein: implications for endosome movement."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0005935"}], "href": "https://doi.org/10.1371/journal.pone.0005935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19529763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19529763"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Na-Young Kim, Mi-Hyang Cho, Se-Hoon Won, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Alzheimers Res Ther (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13195-016-0232-8"}], "href": "https://doi.org/10.1186/s13195-016-0232-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28109317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28109317"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Anthony Ravussin, Andreas Brech, Sharon A Tooze, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.250670"}], "href": "https://doi.org/10.1242/jcs.250670"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33468622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33468622"}]}]}]}
Synonyms	ATG24B
Proteins	SNX4_HUMAN
NCBI Gene ID	8723
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SNX4 has 5,998 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 113 datasets.

Click the + buttons to view associations for SNX4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SNX4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SNX4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SNX4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SNX4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SNX4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SNX4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SNX4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNX4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SNX4 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNX4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SNX4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SNX4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SNX4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SNX4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SNX4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SNX4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SNX4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing SNX4 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SNX4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SNX4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with SNX4 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SNX4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SNX4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SNX4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SNX4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SNX4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SNX4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SNX4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SNX4 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SNX4 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SNX4 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with SNX4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing SNX4 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of SNX4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of SNX4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of SNX4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SNX4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.