{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSOCS2‐AS1 is emerging as an important regulator in cancer biology, with multifaceted roles depending on the tumor context. In androgen receptor–positive prostate cancer, SOCS2‐AS1 is induced by androgen stimulation and its expression is augmented in castration‐resistant cells compared to androgen‐dependent ones. Functionally, SOCS2‐AS1 promotes both castration-resistant and androgen-dependent growth by repressing apoptosis—evidenced by the upregulation of pro-apoptotic genes such as TNFSF10 upon its knockdown—and by enhancing androgen receptor signaling through epigenetic modulation of target genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer, SOCS2‐AS1 appears to function as a tumor suppressor. Its expression is reduced in tumor tissues and low levels correlate with a poorer patient prognosis. Overexpression of SOCS2‐AS1 suppresses cell proliferation, colony formation, cell-cycle progression, migration, and invasion in vitro, as well as tumor growth and metastasis in vivo. Mechanistically, SOCS2‐AS1 exerts its effects through a regulatory loop involving the sequestration of miR-1264, thereby sustaining the expression of the tumor suppressor SOCS2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these solid tumor contexts, SOCS2‐AS1 has also been investigated as part of broader explorations into long noncoding RNAs in cardiovascular and neurovascular diseases. In coronary artery disease, circulating exosomal lncRNAs are being profiled as potential biomarkers, with SOCS2‐AS1 among the candidates under study. Similarly, in Kawasaki disease—where vascular endothelial dysfunction is central—the role of SOCS2‐AS1 in human umbilical vein endothelial cells is under active investigation, and studies in glioma have begun to address its possible involvement in tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other cancer types, SOCS2‐AS1 may play oncogenic roles. In hepatocellular carcinoma, for instance, its function has been linked to the regulation of cancer stem cell properties, which are crucial for tumor recurrence and treatment resistance. Moreover, in papillary thyroid carcinoma, SOCS2‐AS1 is highly expressed and is associated with poor clinical outcomes. Here, it promotes cell proliferation and growth, in part by binding to and destabilizing p53, which in turn accelerates fatty acid oxidation—a metabolic alteration that supports tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aya Misawa, Ken-Ichi Takayama, Tomohiko Urano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Androgen-induced Long Noncoding RNA (lncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.718536"}], "href": "https://doi.org/10.1074/jbc.M116.718536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27342777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27342777"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhihai Zheng, Xiaoxiao Li, Heyi You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103276"}], "href": "https://doi.org/10.18632/aging.103276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32437330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32437330"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Caihong Liang, Lulu Zhang, Xiaoqing Lian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating Exosomal SOCS2-AS1 Acts as a Novel Biomarker in Predicting the Diagnosis of Coronary Artery Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/9182091"}], "href": "https://doi.org/10.1155/2020/9182091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32352013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32352013"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jing Zhao, Daye Chen "}, {"type": "b", "children": [{"type": "t", "text": "Kawasaki disease: SOCS2-AS1/miR-324-5p/CUEDC2 axis regulates the progression of human umbilical vein endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41390-020-1029-9"}], "href": "https://doi.org/10.1038/s41390-020-1029-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32688371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32688371"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dejun Wu, Jinzhang Sun, Hongliang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SOCS2-AS1 promotes the progression of glioma via regulating ITGB1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2021.136248"}], "href": "https://doi.org/10.1016/j.neulet.2021.136248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34536509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34536509"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Feng Zhong, Yuanxi Wang "}, {"type": "b", "children": [{"type": "t", "text": "YY1-regulated lncRNA SOCS2-AS1 suppresses HCC cell stemness and progression via miR-454-3p/CPEB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.08.056"}], "href": "https://doi.org/10.1016/j.bbrc.2023.08.056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37677983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37677983"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaojian Zhang, Xiaozhou Zhang, Guang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SOCS2-AS1 promotes the progression of papillary thyroid cancer by destabilizing p53 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.05.080"}], "href": "https://doi.org/10.1016/j.bbrc.2023.05.080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37267865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37267865"}]}]}]}