{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LLCFC1—corresponding to the gene previously identified as chromosome 7 open reading frame 41—is emerging as an important regulator of megakaryocyte differentiation. In cellular models of leukemic differentiation, LLCFC1 is rapidly induced by 12‑O‑tetradecanoylphorbol‑13‑acetate (TPA) and its upregulation correlates with markers of megakaryocytic maturation such as CD61. Functional studies in K562 cells and mouse fetal liver cells indicate that LLCFC1 enhances key signaling cascades, notably those mediated by ERK and JNK, thereby promoting the expression of pro‑differentiation transcription factors like RUNX1 and FLI1. In addition, LLCFC1 is embedded in a regulatory loop with NF‑κB; NF‑κB activates its expression while LLCFC1 in turn attenuates NF‑κB signaling through inhibition of phosphorylation at serine 536. Mutation of a critical residue (Y34) markedly impairs its differentiation‐promoting capability, underscoring the functional importance of LLCFC1 in mediating both leukemic and normal megakaryocyte lineage commitment (1).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X Sun, B Lu, B Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Cancer J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bcj.2014.18"}], "href": "https://doi.org/10.1038/bcj.2014.18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24681962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24681962"}]}]}]}