{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSOX9‐AS1 is a long non‐coding RNA located adjacent to the oncogenic transcription factor SOX9, and in hepatocellular carcinoma (HCC) it is markedly upregulated. In this cancer type, SOX9‐AS1 drives tumor progression by sponging miR-5590-3p, which in turn elevates SOX9 expression. SOX9 then transcriptionally activates SOX9‐AS1, forming a positive feedback loop that promotes cell proliferation, migration, invasion, and ultimately epithelial-to-mesenchymal transition via activation of the Wnt/β-catenin signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn intrahepatic cholangiocarcinoma (ICC), preliminary investigations have evaluated the clinical relevance and therapeutic potential of SOX9‐AS1. Although details regarding its mechanistic role in ICC remain to be fully elucidated, its expression is emerging as a promising biomarker and potential target for treatment interventions in this aggressive malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a contrasting tumor context, triple-negative breast cancer (TNBC) and basal-like breast cancers display elevated levels of SOX9‐AS1, with its expression predominantly localized in the cytoplasm. Intriguingly, while SOX9‐AS1 is overexpressed in these subtypes, functional studies indicate that its knockdown leads to increased triglyceride synthesis, cell migration, and invasion, suggesting that SOX9‐AS1 may act to temper the aggressive behavior of TNBC cells. This observation is supported by survival analyses showing that high SOX9‐AS1 levels are associated with improved clinical outcomes, likely through the regulation of lipid metabolism and epithelial-to-mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Zhang, Yanhui Wu, Bingwu Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A SOX9-AS1/miR-5590-3p/SOX9 positive feedback loop drives tumor growth and metastasis in hepatocellular carcinoma through the Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12560"}], "href": "https://doi.org/10.1002/1878-0261.12560"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31402556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31402556"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lupeng Wu, Jingrui Yang, Rui-Sheng Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of lncRNA SOX9-AS1 overexpression on the prognosis and progression of intrahepatic cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Res Hepatol Gastroenterol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinre.2022.101999"}], "href": "https://doi.org/10.1016/j.clinre.2022.101999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35870795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35870795"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mireya Cisneros-Villanueva, Marco Antonio Fonseca-Montaño, Magdalena Ríos-Romero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SOX9-AS1 triggers a transcriptional program involved in lipid metabolic reprogramming, cell migration and invasion in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-51947-2"}], "href": "https://doi.org/10.1038/s41598-024-51947-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38233470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38233470"}]}]}]}