SP100 Gene

HGNC Family	Zinc fingers
Name	SP100 nuclear antigen
Description	This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSP100 is a multifunctional nuclear protein that localizes predominantly to nuclear domain 10 (ND10) bodies, where it functions as a key intrinsic antiviral factor. In several studies, SP100, acting in concert with other ND10 components such as PML and hDaxx, has been shown to repress the initiation of viral gene expression and limit DNA replication of diverse viruses—including herpes simplex virus type 1, human cytomegalovirus, and human papillomavirus—through the modulation of chromatin structure and post‐translational modifications (e.g., SUMOylation). In these contexts, depletion of SP100 (especially when combined with depletion of other ND10 factors) results in markedly enhanced viral replication, indicating a cooperative and dose‐dependent repressive potential of SP100 within the ND10 complex."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its antiviral roles, SP100 participates in the regulation of cellular transcription by interacting with critical transcription factors. Studies have demonstrated that SP100 physically associates with ETS1—modulating its DNA binding and transcriptional activities—and can serve as a coactivator for p53 in collaboration with HIPK2. These interactions allow SP100 to exert dual and context‐dependent effects on the expression of target genes that govern processes such as angiogenesis, cellular proliferation, invasion, and apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther studies reveal that viruses have evolved specific strategies to counteract SP100’s functions. Viral proteins such as HSV-1 ICP0 and HCMV IE1 target SP100—disrupting its SUMO modification and subnuclear distribution—to alleviate its transcriptional repression, thereby facilitating viral gene expression and replication. In addition, SP100 has been implicated in modulating viral genome integration and in mediating extracellular antiviral communication via its incorporation into secreted vesicles. Altered SP100 expression also appears to have clinical significance; higher levels are associated with reduced malignancy in brain tumors, and autoantibodies against SP100 serve as diagnostic markers in certain autoimmune conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dmitri G Negorev, Olga V Vladimirova, Alexey Ivanov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02164-05"}], "href": "https://doi.org/10.1128/JVI.02164-05"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16873258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16873258"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marion Lang, Thibaud Jegou, Inn Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Three-dimensional organization of promyelocytic leukemia nuclear bodies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.053496"}], "href": "https://doi.org/10.1242/jcs.053496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20130140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20130140"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Martina Adler, Nina Tavalai, Regina Müller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human cytomegalovirus immediate-early gene expression is restricted by the nuclear domain 10 component Sp100."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1099/vir.0.030981-0"}], "href": "https://doi.org/10.1099/vir.0.030981-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21471311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21471311"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Young-Eui Kim, Jin-Hyoung Lee, Eui Tae Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00758-11"}], "href": "https://doi.org/10.1128/JVI.00758-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21880768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21880768"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mandy Glass, Roger D Everett "}, {"type": "b", "children": [{"type": "t", "text": "Components of promyelocytic leukemia nuclear bodies (ND10) act cooperatively to repress herpesvirus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02950-12"}], "href": "https://doi.org/10.1128/JVI.02950-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23221561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23221561"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wesley H Stepp, Jordan M Meyers, Alison A McBride "}, {"type": "b", "children": [{"type": "t", "text": "Sp100 provides intrinsic immunity against human papillomavirus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mBio.00845-13"}], "href": "https://doi.org/10.1128/mBio.00845-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24194542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24194542"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Julia Berscheminski, Peter Wimmer, Juliane Brun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sp100 isoform-specific regulation of human adenovirus 5 gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00469-14"}], "href": "https://doi.org/10.1128/JVI.00469-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24623443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24623443"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nadine Wagenknecht, Nina Reuter, Myriam Scherer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contribution of the Major ND10 Proteins PML, hDaxx and Sp100 to the Regulation of Human Cytomegalovirus Latency and Lytic Replication in the Monocytic Cell Line THP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Viruses (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/v7062751"}], "href": "https://doi.org/10.3390/v7062751"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26057166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26057166"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Christina Habiger, Günter Jäger, Michael Walter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02137-15"}], "href": "https://doi.org/10.1128/JVI.02137-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26491169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26491169"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Christine Wasylyk, Sophie E Schlumberger, Paola Criqui-Filipe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sp100 interacts with ETS-1 and stimulates its transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.8.2687-2702.2002"}], "href": "https://doi.org/10.1128/MCB.22.8.2687-2702.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11909962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11909962"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Andreas Möller, Hüseyin Sirma, Thomas G Hofmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207079"}], "href": "https://doi.org/10.1038/sj.onc.1207079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14647468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14647468"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "John S Yordy, Runzhao Li, Victor I Sementchenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207891"}], "href": "https://doi.org/10.1038/sj.onc.1207891"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15247905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15247905"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "John S Yordy, Omar Moussa, Huiping Pei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SP100 inhibits ETS1 activity in primary endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208245"}], "href": "https://doi.org/10.1038/sj.onc.1208245"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15592518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15592518"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Paul D Ling, Rong Sheng Peng, Ayako Nakajima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600820"}], "href": "https://doi.org/10.1038/sj.emboj.7600820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16177824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16177824"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wei Li, Chao Shang, Chao Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low expression of Sp100 in laryngeal cancer: correlation with cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20512085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20512085"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yun Lin, Zhi-hui Li, Jing-Jing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sp100 interacts with phage ΦC31 integrase to inhibit its recombination activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Pol (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21383994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21383994"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yuan-Yuan Xue, Ran Wang, Yang-Bo Yue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role and fate of SP100 protein in response to Rep-dependent nonviral integration system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Microbiol Biotechnol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00253-012-3992-5"}], "href": "https://doi.org/10.1007/s00253-012-3992-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22419217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22419217"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiaojie Zhang, Dan Zhao, Xiaozhe Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.721159"}], "href": "https://doi.org/10.1074/jbc.M116.721159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27129259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27129259"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Pei Xu, Bernard Roizman "}, {"type": "b", "children": [{"type": "t", "text": "The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1703395114"}], "href": "https://doi.org/10.1073/pnas.1703395114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28439026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28439026"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Wesley H Stepp, James D Stamos, Simran Khurana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1006660"}], "href": "https://doi.org/10.1371/journal.ppat.1006660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28968443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28968443"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Anirban Sanyal, Nina Wallaschek, Mandy Glass, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide Association Studies of Specific Antinuclear Autoantibody Subphenotypes in Primary Biliary Cholangitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.30604"}], "href": "https://doi.org/10.1002/hep.30604"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30854688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30854688"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yilei Ma, Jingjing Li, Hongchang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PML Body Component Sp100A Restricts Wild-Type Herpes Simplex Virus 1 Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.00279-22"}], "href": "https://doi.org/10.1128/jvi.00279-22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35353002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35353002"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xiang Gu, Ai Zhuang, Jie Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkad1193"}], "href": "https://doi.org/10.1093/nar/gkad1193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38118002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38118002"}]}]}]}
Synonyms	LYSP100B
Proteins	SP100_HUMAN
NCBI Gene ID	6672
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SP100 has 11,934 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for SP100 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SP100 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SP100 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SP100 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SP100 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SP100 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SP100 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving SP100 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SP100 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SP100 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SP100 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SP100 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SP100 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SP100 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SP100 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SP100 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SP100 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SP100 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SP100 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing SP100 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SP100 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SP100 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SP100 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SP100 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SP100 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SP100 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SP100 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SP100 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SP100 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SP100 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SP100 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SP100 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SP100 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SP100 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SP100 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SP100 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SP100 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SP100 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SP100 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SP100 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SP100 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of SP100 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.