SPHK1 Gene

Name sphingosine kinase 1
Description The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSphingosine kinase 1 (SPHK1) is a pivotal enzyme that phosphorylates sphingosine to yield sphingosine‐1‐phosphate (S1P), a bioactive lipid second messenger that regulates a wide array of cellular processes. Its activation is mediated by agonist‐induced phosphorylation events (for example, phosphorylation at Ser225 by ERK1/2), protein kinase C activation, and critical lipid–protein interactions that promote its translocation from the cytosol to the plasma membrane. Furthermore, SPHK1 function is modulated by interactions with signaling molecules such as TRAF2 and CIB1, while conserved residues in its structure ensure selective binding to phospholipids that target the enzyme to appropriate membrane sites."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pathophysiological settings, SPHK1 emerges as a critical survival and oncogenic factor. Elevated SPHK1 activity promotes anti‐apoptotic signaling via the PI3K/Akt and NF‑κB pathways, contributing to cell proliferation, chemoresistance, and the enhanced production of inflammatory mediators. Such oncogenic roles have been documented in several cancers – including those of the breast, colon, prostate, and stomach – where high SPHK1 expression correlates with tumor progression, metastasis, and poor clinical prognosis. In addition, SPHK1‐derived S1P participates in restoring endothelial barrier function during inflammatory stress and modulates mast cell degranulation and cytokine release, further underscoring its significance in inflammation and immunity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSPHK1 expression and activity are also intricately controlled by regulatory noncoding RNAs and other post‐transcriptional mechanisms. For instance, long noncoding RNAs such as HULC and Khps1 have been shown to up‐regulate SPHK1 via E2F1‐dependent promoter activation, whereas microRNAs like miR‑124 suppress its expression and attenuate tumorigenicity. Moreover, specialized isoforms of SPHK1 are secreted by endothelial cells to establish the vascular S1P gradient, and SPHK1 activity contributes to cellular adaptation under hypoxic conditions by modulating HIF‑1α stabilization. Additionally, inhibition of SPHK1 – whether by DNA damaging agents that trigger its proteasomal degradation or by small‑molecule inhibitors that promote autoinhibition – can shift the sphingolipid rheostat to favor apoptosis and restore insulin sensitivity. Crosstalk between SPHK1 and receptor tyrosine kinases, including EGFR, further emphasizes its multifaceted roles in both normal physiology and disease, making it a promising target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pu Xia, Lijun Wang, Paul A B Moretti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111423200"}], "href": "https://doi.org/10.1074/jbc.M111423200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11777919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11777919"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Korey R Johnson, Kevin P Becker, Maria Marta Facchinetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M203033200"}], "href": "https://doi.org/10.1074/jbc.M203033200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12124383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12124383"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Stuart M Pitson, Paul A B Moretti, Julia R Zebol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg540"}], "href": "https://doi.org/10.1093/emboj/cdg540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14532121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14532121"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Robert V Stahelin, Jeong H Hwang, Jin-Hahn Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mechanism of membrane targeting of human sphingosine kinase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M507574200"}], "href": "https://doi.org/10.1074/jbc.M507574200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16243846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16243846"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kate E Jarman, Paul A B Moretti, Julia R Zebol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.068395"}], "href": "https://doi.org/10.1074/jbc.M109.068395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19854831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19854831"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tarek A Taha, Walid Osta, Lina Kozhaya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401259200"}], "href": "https://doi.org/10.1074/jbc.M401259200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14988393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14988393"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Vidya Limaye, Xiaochun Li, Chris Hahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-02-0452"}], "href": "https://doi.org/10.1182/blood-2004-02-0452"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15632208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15632208"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Andreas Billich, Frédéric Bornancin, Diana Mechtcheriakova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2004.12.005"}], "href": "https://doi.org/10.1016/j.cellsig.2004.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16038795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16038795"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yukihiro Akao, Yoshiko Banno, Yoshihito Nakagawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.02.070"}], "href": "https://doi.org/10.1016/j.bbrc.2006.02.070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16516161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16516161"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Eugen Ruckhäberle, Achim Rody, Knut Engels, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-007-9836-9"}], "href": "https://doi.org/10.1007/s10549-007-9836-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18058224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18058224"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Carole A Oskeritzian, Sergio E Alvarez, Nitai C Hait, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-09-115451"}], "href": "https://doi.org/10.1182/blood-2007-09-115451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18178871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18178871"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Toshihiko Kawamori, Tatsuya Kaneshiro, Masae Okumura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role for sphingosine kinase 1 in colon carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-117572"}], "href": "https://doi.org/10.1096/fj.08-117572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18824518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18824518"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mohammad Tauseef, Vidisha Kini, Nebojsa Knezevic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000338501.84810.51"}], "href": "https://doi.org/10.1161/01.RES.0000338501.84810.51"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18849324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18849324"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wen-Qi Lai, Anastasia Windy Irwan, Hong Heng Goh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.181.11.8010"}], "href": "https://doi.org/10.4049/jimmunol.181.11.8010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19017993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19017993"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Krishnan Venkataraman, Shobha Thangada, Jason Michaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20060251"}], "href": "https://doi.org/10.1042/BJ20060251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16623665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16623665"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Isabelle Ader, Leyre Brizuela, Pierre Bouquerel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-0917"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-0917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18922940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18922940"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Carolyn Loveridge, Francesca Tonelli, Tamara Leclercq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.127993"}], "href": "https://doi.org/10.1074/jbc.M110.127993"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20926375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20926375"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Keng G Lim, Francesca Tonelli, Zaiguo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.220756"}], "href": "https://doi.org/10.1074/jbc.M111.220756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21464128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21464128"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jintang Xia, Zhiqiang Wu, Chunping Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4030"}], "href": "https://doi.org/10.1002/path.4030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22450659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22450659"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Clinton R Bruce, Steve Risis, Joanne R Babb, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db12-0029"}], "href": "https://doi.org/10.2337/db12-0029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22961081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22961081"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Roberta Rosa, Roberta Marciano, Umberto Malapelle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-12-1050"}], "href": "https://doi.org/10.1158/1078-0432.CCR-12-1050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23166225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23166225"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zhanping Lu, Zelin Xiao, Fabao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6280"}], "href": "https://doi.org/10.18632/oncotarget.6280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26540633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26540633"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Anna Postepska-Igielska, Alena Giwojna, Lital Gasri-Plotnitsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.10.001"}], "href": "https://doi.org/10.1016/j.molcel.2015.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26590717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26590717"}]}]}]}
Synonyms SPHK
Proteins SPHK1_HUMAN
NCBI Gene ID 8877
API
Download Associations
Predicted Functions View SPHK1's ARCHS4 Predicted Functions.
Co-expressed Genes View SPHK1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SPHK1's ARCHS4 Predicted Functions.

Functional Associations

SPHK1 has 10,523 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for SPHK1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by SPHK1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SPHK1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of SPHK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of SPHK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SPHK1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
Biocarta Pathways pathways involving SPHK1 protein from the Biocarta Pathways dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of SPHK1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SPHK1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SPHK1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SPHK1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of SPHK1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with SPHK1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SPHK1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SPHK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of SPHK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SPHK1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing SPHK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing SPHK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores cellular components containing SPHK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing SPHK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with SPHK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with SPHK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SPHK1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with SPHK1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with SPHK1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with SPHK1 gene/protein from the curated CTD Gene-Disease Associations dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by SPHK1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DEPOD Substrates of Phosphatases phosphatases that dephosphorylate SPHK1 protein from the curated DEPOD Substrates of Phosphatases dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with SPHK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with SPHK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with SPHK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with SPHK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
DrugBank Drug Targets interacting drugs for SPHK1 protein from the curated DrugBank Drug Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SPHK1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SPHK1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SPHK1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing SPHK1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of SPHK1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with SPHK1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing SPHK1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of SPHK1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SPHK1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of SPHK1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SPHK1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SPHK1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of SPHK1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving SPHK1 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving SPHK1 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving SPHK1 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing SPHK1 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing SPHK1 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing SPHK1 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by SPHK1 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by SPHK1 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by SPHK1 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of SPHK1 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SPHK1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of SPHK1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SPHK1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Guide to Pharmacology Chemical Ligands of Receptors ligands (chemical) binding SPHK1 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of SPHK1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes interacting metabolites for SPHK1 protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of SPHK1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of SPHK1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of SPHK1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of SPHK1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for SPHK1 from the curated Hub Proteins Protein-Protein Interactions dataset.
HumanCyc Pathways pathways involving SPHK1 protein from the HumanCyc Pathways dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by SPHK1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for SPHK1 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SPHK1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate SPHK1 protein from the curated KEA Substrates of Kinases dataset.
KEGG Pathways pathways involving SPHK1 protein from the KEGG Pathways dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SPHK1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of SPHK1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with SPHK1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of SPHK1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of SPHK1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of SPHK1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SPHK1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain SPHK1 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by SPHK1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting SPHK1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SPHK1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of SPHK1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by SPHK1 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of SPHK1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
MW Enzyme Metabolite Associations interacting metabolites for SPHK1 protein from the MW Gene Metabolite Associations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of SPHK1 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing SPHK1 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
PANTHER Pathways pathways involving SPHK1 protein from the PANTHER Pathways dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for SPHK1 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SPHK1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of SPHK1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving SPHK1 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving SPHK1 protein from the Wikipathways PFOCR 2024 dataset.
Phosphosite Textmining Biological Term Annotations biological terms co-occuring with SPHK1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
PhosphoSitePlus Substrates of Kinases kinases that phosphorylate SPHK1 protein from the curated PhosphoSitePlus Substrates of Kinases dataset.
PID Pathways pathways involving SPHK1 protein from the PID Pathways dataset.
Reactome Pathways 2014 pathways involving SPHK1 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving SPHK1 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SPHK1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SPHK1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of SPHK1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of SPHK1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SPHK1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SPHK1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of SPHK1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of SPHK1 gene from the RummaGEO Gene Perturbation Signatures dataset.
SynGO Synaptic Gene Annotations synaptic terms associated with SPHK1 gene from the SynGO Synaptic Gene Annotations dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of SPHK1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of SPHK1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of SPHK1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SPHK1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of SPHK1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SPHK1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of SPHK1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SPHK1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with SPHK1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with SPHK1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving SPHK1 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving SPHK1 protein from the WikiPathways Pathways 2024 dataset.