{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSPMIP3, which in this context is functionally analogous to the GDP‐fucose transporter SLC35C1, is essential for the fucosylation of selectin ligands expressed on leukocytes. This glycosylation step is critical for mediating interactions with E‐, L‐, and P‐selectins on the vascular endothelium, thereby facilitating the initial rolling of leukocytes along vessel walls during the inflammatory response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Disruption of SPMIP3 function in murine models leads to a near‐complete loss of selectin‐dependent rolling and a consequent strong reduction in firm adhesion of leukocytes to the endothelium. Notably, neutrophil migration to sites of inflammation is reduced by approximately 89%, underscoring the protein’s pivotal role in innate immune cell recruitment and the overall orchestration of an effective inflammatory response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Interestingly, while the absence of SPMIP3 impairs lymphocyte homing to peripheral lymph nodes—with homing efficiencies dropping to only 1–2%—lymphocyte trafficking to the spleen remains unaffected. This tissue-specific discrepancy is reflected in the corresponding humoral responses, where T cell-dependent antigen responses are defective in lymph nodes but normal in the spleen, indicating that SPMIP3-mediated modifications selectively impact leukocyte subsets and their migratory routes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sviatlana Yakubenia, David Frommhold, Dirk Schölch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-01-132035"}], "href": "https://doi.org/10.1182/blood-2008-01-132035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18541720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18541720"}]}]}]}