SPRY4-IT1 Gene

HGNC Family Non-coding RNAs
Name SPRY4 intronic transcript 1
Description This gene produces a non-coding RNA that is upregulated in several different tumors, including melanoma and breast and prostate cancer cells. This transcript may mediate cell growth, proliferation, and apoptosis. It regulates levels of lipin 2, and therefore may be involved in lipid biosynthesis. The primary transcript is cleaved to release a mature product that localizes to the cytoplasm (PMID:25344859). The full length structure of the primary and cleaved transcripts is unclear, and it is possible that the primary transcript is a splice variant of SPRY4 (sprouty RTK signaling antagonist 4). [provided by RefSeq, Feb 2016]
Synonyms SPRIGHTLY
NCBI Gene ID 100642175
API
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Predicted Functions View SPRY4-IT1's ARCHS4 Predicted Functions.
Co-expressed Genes View SPRY4-IT1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SPRY4-IT1's ARCHS4 Predicted Functions.

Functional Associations

SPRY4-IT1 has 11 functional associations with biological entities spanning 4 categories (organism, functional term, phrase or reference, disease, phenotype or trait, gene, protein or microRNA) extracted from 5 datasets.

Click the + buttons to view associations for SPRY4-IT1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
GeneRIF Biological Term Annotations biological terms co-occuring with SPRY4-IT1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of SPRY4-IT1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SPRY4-IT1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SPRY4-IT1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of SPRY4-IT1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.