SPTBN1 Gene

HGNC Family	Pleckstrin homology domain containing (PLEKH)
Name	spectrin, beta, non-erythrocytic 1
Description	Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nβII‐spectrin, encoded by SPTBN1, is a ubiquitously expressed cytoskeletal adaptor that plays a key role in maintaining plasma membrane organization and cellular structural integrity. In epithelial cells, βII‐spectrin collaborates with ankyrin‐G to target and stabilize E‐cadherin at lateral membranes, thereby promoting proper cell–cell adhesion and membrane biogenesis. Its ability to form spectrin tetramers and to associate with lipid membranes is tightly regulated—phosphorylation of specific serine/threonine residues modulates tetramer formation and the structural conformation of critical domains that distinguish βII‐spectrin from other isoforms. These structural and biochemical features ensure an effective linkage between membrane proteins and the actin cytoskeleton, facilitating proper cellular architecture."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its structural role, SPTBN1 functions as a pivotal signal transduction adaptor in the transforming growth factor‐β (TGF‑β)/Smad pathway, where it facilitates Smad3/Smad4 complex assembly and thereby contributes to tumor suppression. Loss or disruption of SPTBN1 has been linked to dedifferentiation and enhanced tumorigenicity in several cancers—including hepatocellular carcinoma, pancreatic, ovarian, breast, and lung adenocarcinoma—through deregulation of key pathways (NF‑κB, STAT3, and JAK/STAT) and by promoting epithelial–mesenchymal transition (EMT) as well as altering the inflammatory tumor microenvironment. Moreover, SPTBN1 has emerged in oncogenic fusion events (such as SPTBN1–ALK and SPTBN1–PDGFRB), further underscoring its role as both a biomarker and a potential therapeutic target in malignancy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in epithelial homeostasis and tumor suppression, SPTBN1 is critical for neural development and for the proper function of diverse tissues. In the central nervous system, βII‐spectrin is essential for establishing neuronal architecture and synaptic organization, with pathogenic variants linked to a neurodevelopmental syndrome characterized by cognitive, language, and motor delays. Moreover, SPTBN1 influences other physiological processes such as macrophage polarization and cardiac contractility, impacting immune regulation and post‐injury tissue remodeling. Collectively, these findings position SPTBN1 as a multifunctional protein whose dysregulation underlies a spectrum of human diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Krishnakumar Kizhatil, Jonathan Q Davis, Lydia Davis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M703158200"}], "href": "https://doi.org/10.1074/jbc.M703158200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17620337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17620337"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Krishnakumar Kizhatil, Woohyun Yoon, Peter J Mohler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M608921200"}], "href": "https://doi.org/10.1074/jbc.M608921200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17074766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17074766"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Paola A Bignone, Mikayala D A King, Jennifer C Pinder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M605920200"}], "href": "https://doi.org/10.1074/jbc.M605920200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17088250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17088250"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ewa Bok, Ewa Plazuk, Anita Hryniewicz-Jankowska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lipid-binding role of betaII-spectrin ankyrin-binding domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellbi.2007.06.014"}], "href": "https://doi.org/10.1016/j.cellbi.2007.06.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17716929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17716929"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuanli Song, Chloe Antoniou, Adnan Memic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pro.617"}], "href": "https://doi.org/10.1002/pro.617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21412925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21412925"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiuling Zhi, Ling Lin, Shaoxian Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "βII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.27558"}], "href": "https://doi.org/10.1002/hep.27558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25307947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25307947"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ling Lin, Shuyi Chen, Hua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.49819"}], "href": "https://doi.org/10.7150/thno.49819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33754058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33754058"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ling Lin, Zhixing Yao, Krithika Bhuvaneshwar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding proteins ATF3 and CREB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgu163"}], "href": "https://doi.org/10.1093/carcin/bgu163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25096061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25096061"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Fei-Fei Gu, Yong Zhang, Yang-Yang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lung adenocarcinoma harboring concomitant SPTBN1-ALK fusion, c-Met overexpression, and HER-2 amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-016-0296-8"}], "href": "https://doi.org/10.1186/s13045-016-0296-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27496196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27496196"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Genevieve Gallagher, Douglas E Horsman, Peter Tsang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fusion of PRKG2 and SPTBN1 to the platelet-derived growth factor receptor beta gene (PDGFRB) in imatinib-responsive atypical myeloproliferative disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet Cytogenet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergencyto.2007.10.021"}], "href": "https://doi.org/10.1016/j.cancergencyto.2007.10.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18262053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18262053"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiaohua Jiang, Sonja Gillen, Irene Esposito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced expression of the membrane skeleton protein beta1-spectrin (SPTBN1) is associated with worsened prognosis in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-25.1497"}], "href": "https://doi.org/10.14670/HH-25.1497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20886430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20886430"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mo Chen, Jia Zeng, Shuyi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPTBN1 suppresses the progression of epithelial ovarian cancer via SOCS3-mediated blockade of the JAK/STAT3 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103303"}], "href": "https://doi.org/10.18632/aging.103303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32516133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32516133"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yuhua Chen, Lingling Meng, Haitao Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0456-6"}], "href": "https://doi.org/10.1038/s41419-018-0456-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29555987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29555987"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yan-Hua Deng, Lin Zhao, Min-Jia Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12020-012-9726-8"}], "href": "https://doi.org/10.1007/s12020-012-9726-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22798246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22798246"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Huijie Wu, Nan Jiang, Jiajia Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor cell SPTBN1 inhibits M2 polarization of macrophages by suppressing CXCL1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.31146"}], "href": "https://doi.org/10.1002/jcp.31146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37921259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37921259"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Huijie Wu, Shuyi Chen, Chenyang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPTBN1 inhibits growth and epithelial-mesenchymal transition in breast cancer by downregulating miR-21."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2021.174401"}], "href": "https://doi.org/10.1016/j.ejphar.2021.174401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34358482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34358482"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wenting Tang, Qiong Shao, Zhanwen He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of nonerythrocytic spectrin Beta 1 (SPTBN1) in human kidney renal clear cell carcinoma and uveal melanoma: a study based on Pan-Cancer Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-023-10789-3"}], "href": "https://doi.org/10.1186/s12885-023-10789-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37013511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37013511"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Margot A Cousin, Blake A Creighton, Keith A Breau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41588-021-00886-z"}], "href": "https://doi.org/10.1038/s41588-021-00886-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34211179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34211179"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Panyu Yang, Yanyan Yang, Pin Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "βII spectrin (SPTBN1): biological function and clinical potential in cancer and other diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.52375"}], "href": "https://doi.org/10.7150/ijbs.52375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33390831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33390831"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hak Joo Lee, Kyunghee Lee, Hana Im "}, {"type": "b", "children": [{"type": "t", "text": "α-Synuclein modulates neurite outgrowth by interacting with SPTBN1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2012.06.143"}], "href": "https://doi.org/10.1016/j.bbrc.2012.06.143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22771809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22771809"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jill A Rosenfeld, Rui Xiao, Mir Reza Bekheirnia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterozygous variants in SPTBN1 cause intellectual disability and autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.62201"}], "href": "https://doi.org/10.1002/ajmg.a.62201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33847457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33847457"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Rongjin Yang, Banjun Ruan, Rutao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiomyocyte βII spectrin plays a critical role in maintaining cardiac function by regulating mitochondrial respiratory function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvae116"}], "href": "https://doi.org/10.1093/cvr/cvae116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38832923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38832923"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Li-Ping Dai, Xiao-Dong Xu, Ting-Ting Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPTBN1 attenuates rheumatoid arthritis synovial cell proliferation, invasion, migration and inflammatory response by binding to PIK3R2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immun Inflamm Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iid3.724"}], "href": "https://doi.org/10.1002/iid3.724"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36444616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36444616"}]}]}]}
Synonyms	HEL102, SPTB2, BETASPII, ELF
Proteins	SPTB2_HUMAN
NCBI Gene ID	6711
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SPTBN1 has 21,555 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 141 datasets.

Click the + buttons to view associations for SPTBN1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SPTBN1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SPTBN1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SPTBN1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SPTBN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SPTBN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SPTBN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SPTBN1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SPTBN1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SPTBN1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SPTBN1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SPTBN1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SPTBN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SPTBN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SPTBN1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SPTBN1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SPTBN1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SPTBN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SPTBN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SPTBN1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SPTBN1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SPTBN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SPTBN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SPTBN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SPTBN1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SPTBN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SPTBN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SPTBN1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SPTBN1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SPTBN1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SPTBN1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SPTBN1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SPTBN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with SPTBN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SPTBN1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SPTBN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SPTBN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SPTBN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SPTBN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for SPTBN1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SPTBN1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SPTBN1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.