{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe steroid receptor RNA activator 1 (SRA1) gene is a remarkable bifunctional locus that produces both a long non‐coding RNA and a protein product (SRAP), each of which exhibits distinct biochemical properties. Detailed biochemical and structural analyses have revealed that the SRA RNA adopts a complex secondary structure—organized into multiple domains, including a critical Domain III with conserved helical elements (e.g., helices H15–H18)—and that alternative splicing events modulate the balance between coding and non‐coding isoforms. These studies also show that the SRAP protein lacks a canonical RNA recognition motif despite earlier predictions, underscoring that evolutionary pressure has maintained the RNA structural core over the protein’s coding capacity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA central function of SRA1 is its capacity to coactivate nuclear receptor–mediated transcription. Acting in concert with established coactivators and coregulators, SRA RNA (and in some contexts its protein product) enhances transcriptional activity of several steroid hormone receptors—including estrogen receptor (ERα), androgen receptor (AR), and nuclear factors such as SF‑1—and modulates transcription in a ligand‐dependent or –independent manner. In addition, SRA1 participates in unconventional regulatory complexes such as those involving the RNA helicase p68, the insulator factor CTCF, and cohesin, thereby influencing chromatin organization and proper insulator function. Its involvement in fine‐tuning receptor activity has been documented in diverse biological systems, ranging from ovarian tumors and endometriotic tissues to settings of steroidogenesis and myogenic differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in transcriptional coactivation, SRA1 exerts profound effects on cell fate and disease pathogenesis. Aberrant SRA1 expression or splicing regulation has been associated with diverse malignancies—including breast, ovarian, colorectal, osteosarcoma, and renal cell carcinomas—as well as with cardiomyopathy, metabolic disorders, and even neuropsychiatric conditions such as poststroke depression. In cancer cells SRA1 influences proliferation, apoptosis, epithelial–mesenchymal transition, and stem cell properties, while genetic variants in SRA1 have been linked to altered breast cancer risk and benign breast disease. Furthermore, in metabolic tissues its expression correlates with markers of obesity, type 2 diabetes, and inflammatory signaling, and in pancreatic β‑cells it acts as a competing endogenous RNA to modulate microRNA function. Additional roles include regulation of pluripotency via interactions with chromatin modifiers (TrxG and PRC2) and modulation of steroid receptor signaling through posttranscriptional modifications such as pseudouridylation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ilaria T R Cavarretta, Ratna Mukopadhyay, David M Lonard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/mend.16.2.0770"}], "href": "https://doi.org/10.1210/mend.16.2.0770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11818499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11818499"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ethan Emberley, Guo-Jian Huang, Mohammad K Hamedani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of new human coding steroid receptor RNA activator isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(02)03070-x"}], "href": "https://doi.org/10.1016/s0006-291x(02"}, {"type": "t", "text": "03070-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12565891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12565891"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Geneviève Deblois, Vincent Giguère "}, {"type": "b", "children": [{"type": "t", "text": "Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0960-0760(03)00225-5"}], "href": "https://doi.org/10.1016/s0960-0760(03"}, {"type": "t", "text": "00225-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12943696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12943696"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kevin M Coleman, Vinh Lam, Basem M Jaber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.08.090"}], "href": "https://doi.org/10.1016/j.bbrc.2004.08.090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15351741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15351741"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Florent Hube, Jimin Guo, Shilpa Chooniedass-Kothari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2006.25.418"}], "href": "https://doi.org/10.1089/dna.2006.25.418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16848684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16848684"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Irina V Novikova, Scott P Hennelly, Karissa Y Sanbonmatsu "}, {"type": "b", "children": [{"type": "t", "text": "Structural architecture of the human long non-coding RNA, steroid receptor RNA activator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gks071"}], "href": "https://doi.org/10.1093/nar/gks071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22362738"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22362738"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "David B McKay, Linghe Xi, Kristen K B Barthel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2014.01.006"}], "href": "https://doi.org/10.1016/j.jmb.2014.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24486609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24486609"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Stephanie M Bilinovich, Caroline M Davis, Daniel L Morris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does not directly bind to the SRA1 RNA STR7 region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2014.01.007"}], "href": "https://doi.org/10.1016/j.jmb.2014.01.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24486611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24486611"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Euihan Jung, Seonghui Jang, Jungmin Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Truncated SRA RNA derivatives inhibit estrogen receptor-α-mediated transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-016-4039-2"}], "href": "https://doi.org/10.1007/s11033-016-4039-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27406387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27406387"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "S Hussein-Fikret, P J Fuller "}, {"type": "b", "children": [{"type": "t", "text": "Expression of nuclear receptor coregulators in ovarian stromal and epithelial tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2004.08.005"}], "href": "https://doi.org/10.1016/j.mce.2004.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15607539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15607539"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Bin Xu, Wei-Hsiung Yang, Isabelle Gerin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01010-08"}], "href": "https://doi.org/10.1128/MCB.01010-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19188450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19188450"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Charlton Cooper, Jimin Guo, Yi Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkp441"}], "href": "https://doi.org/10.1093/nar/gkp441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19483093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19483093"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Nicole Borth, Julia Massier, Claudia Franke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chlamydial protease CT441 interacts with SRAP1 co-activator of estrogen receptor alpha and partially alleviates its co-activation activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2010.01.004"}], "href": "https://doi.org/10.1016/j.jsbmb.2010.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20079837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20079837"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shilpa Chooniedass-Kothari, Daniel Vincett, Yi Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2010.02.024"}], "href": "https://doi.org/10.1016/j.febslet.2010.02.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20153324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20153324"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Charles E Foulds, Anna Tsimelzon, Weiwen Long, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2009-0427"}], "href": "https://doi.org/10.1210/me.2009-0427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20219889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20219889"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hongjie Yao, Kevin Brick, Yvonne Evrard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1967810"}], "href": "https://doi.org/10.1101/gad.1967810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20966046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20966046"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sajal K Ghosh, Jeffrey R Patton, Remco A Spanjaard "}, {"type": "b", "children": [{"type": "t", "text": "A small RNA derived from RNA coactivator SRA blocks steroid receptor signaling via inhibition of Pus1p-mediated pseudouridylation of SRA: evidence of a novel RNA binding domain in the N-terminus of steroid receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi300602r"}], "href": "https://doi.org/10.1021/bi300602r"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22998747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22998747"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Kaiqing Lin, Junyan Ma, Ruijin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Influence of ovarian endometrioma on expression of steroid receptor RNA activator, estrogen receptors, vascular endothelial growth factor, and thrombospondin 1 in the surrounding ovarian tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1933719113492205"}], "href": "https://doi.org/10.1177/1933719113492205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23749764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23749764"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Shilpa Chooniedass-Kothari, Mohammad Kariminia Hamedani, Sandy Troup, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The steroid receptor RNA activator protein is expressed in breast tumor tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.21425"}], "href": "https://doi.org/10.1002/ijc.21425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16152589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16152589"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zhenteng Liu, Cuifang Hao, Xin Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peripheral blood leukocyte expression level of lncRNA steroid receptor RNA activator (SRA) and its association with polycystic ovary syndrome: a case control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/09513590.2014.999763"}], "href": "https://doi.org/10.3109/09513590.2014.999763"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25609053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25609053"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Patompon Wongtrakoongate, Gregory Riddick, Suthat Fucharoen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1005615"}], "href": "https://doi.org/10.1371/journal.pgen.1005615"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26496121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26496121"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yi Yan, Charlton Cooper, Mohammad K Hamedani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The steroid receptor RNA activator protein (SRAP) controls cancer cell migration/motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2015.11.007"}], "href": "https://doi.org/10.1016/j.febslet.2015.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26581859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26581859"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Rui Yan, Kaijuan Wang, Rui Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in lncRNA SRA and risk of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7995"}], "href": "https://doi.org/10.18632/oncotarget.7995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26967566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26967566"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Chan Liu, Hong-Tao Wu, Neng Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Steroid receptor RNA activator: Biologic function and role in disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2016.06.004"}], "href": "https://doi.org/10.1016/j.cca.2016.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27282881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27282881"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Kaiqing Lin, Hong Zhan, Junyan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of SRA1 Regulates ER Expression and Attenuates the Growth of Stromal Cells in Ovarian Endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1933719116670036"}], "href": "https://doi.org/10.1177/1933719116670036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27694140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27694140"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Ping Luo, Wei Jing, Man Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of LncRNA SRA1 in hepatocellular carcinoma and its clinical significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-160305"}], "href": "https://doi.org/10.3233/CBM-160305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28085012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28085012"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Kyung Jin Eoh, Jiheum Paek, Sang Wun Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA, steroid receptor RNA activator (SRA), induces tumor proliferation and invasion through the NOTCH pathway in cervical cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.6023"}], "href": "https://doi.org/10.3892/or.2017.6023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29039612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29039612"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Wen Guo, Haitao Jiang, Haijun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-SRA1 Suppresses Osteosarcoma Cell Proliferation While Promoting Cell Apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033819841438"}], "href": "https://doi.org/10.1177/1533033819841438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31106680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31106680"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Baoying Jiang, Hongwei Wang, Houchi Xu "}, {"type": "b", "children": [{"type": "t", "text": "Steroid receptor RNA activator affects the development of poststroke depression by regulating the peroxisome proliferator-activated receptor γ signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroreport (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/WNR.0000000000001367"}], "href": "https://doi.org/10.1097/WNR.0000000000001367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31714481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31714481"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Jifan Tan, XiuLan Hao, TingTing Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Assist Reprod Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10815-020-01922-3"}], "href": "https://doi.org/10.1007/s10815-020-01922-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32783135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32783135"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Chanjuan Zhang, Neng Zhu, Chan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2020.4730"}], "href": "https://doi.org/10.3892/ijmm.2020.4730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33000206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33000206"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Yu-Nan Huang, Shang-Lun Chiang, Yu-Jung Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long, Noncoding RNA SRA Induces Apoptosis of β-Cells by Promoting the IRAK1/LDHA/Lactate Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22041720"}], "href": "https://doi.org/10.3390/ijms22041720"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33572095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33572095"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Lee Kyung Kim, Sun-Ae Park, Yoolhee Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20210565"}], "href": "https://doi.org/10.1042/BSR20210565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34402503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34402503"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Shihab Kochumon, Hossein Arefanian, Sardar Sindhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10102602"}], "href": "https://doi.org/10.3390/cells10102602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34685582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34685582"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "I M Lukavenko, A V Kolnoguz, Z M Levchenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Positive association between SRA1 rs801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.32471/exp-oncology.2312-8852.vol-43-no-4.16852"}], "href": "https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-4.16852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34967547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34967547"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Liqin Zhao, Shiyi Liang, Chijian Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ratios of peripheral blood mononuclear cells to lncRNA steroid receptor RNA activator as new indicators of metabolic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endokrynol Pol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5603/EP.a2021.0106"}], "href": "https://doi.org/10.5603/EP.a2021.0106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35119092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35119092"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Shihab Kochumon, Hossein Arefanian, Sardar Sindhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells11244007"}], "href": "https://doi.org/10.3390/cells11244007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36552771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36552771"}]}]}]}