{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSteroid receptor‐associated and regulated protein (SRARP) is a newly identified tumor suppressor gene located on chromosome 1p36.13. It is frequently inactivated across various malignancies by deletions and epigenetic silencing, and this early inactivation correlates strongly with adverse clinical outcomes. The loss of SRARP function appears to be an early event in carcinogenesis, with lower expression and hypermethylation in both tumor and adjacent normal tissues predicting poorer survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nSteroid receptor‐associated and regulated protein exerts its tumor suppressor effects through multiple mechanisms. Functionally, SRARP reduces clonogenicity and decreases cell viability by downregulating key pro‐survival and proliferation signaling pathways, including Akt and ERK. Its expression is intricately regulated by the androgen receptor (AR), which not only suppresses SRARP transcription when hyperactivated but also is necessary at a basal level to sustain its expression in AR‐positive cancer cells. Furthermore, SRARP shares molecular features with paired genes such as HSPB7, including an interaction with the 14-3-3 protein, suggesting that coordinated regulation within this genomic region plays a critical role in modulating tumor progression and cell signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ali Naderi "}, {"type": "b", "children": [{"type": "t", "text": "SRARP and HSPB7 are epigenetically regulated gene pairs that function as tumor suppressors and predict clinical outcome in malignancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12195"}], "href": "https://doi.org/10.1002/1878-0261.12195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29577611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29577611"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ali Naderi "}, {"type": "b", "children": [{"type": "t", "text": "Steroid receptor-associated and regulated protein is a biomarker in predicting the clinical outcome and treatment response in malignancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Rep (Hoboken) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cnr2.1267"}], "href": "https://doi.org/10.1002/cnr2.1267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32706923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32706923"}]}]}]}