SRP19 Gene

Name	signal recognition particle 19kDa
Description	Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in cytosol; nuclear body; and nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSRP19 is a pivotal RNA‐binding protein that orchestrates the early steps of signal recognition particle (SRP) assembly by interacting with conserved tetraloop elements at the apices of helices 6 and 8 in the SRP RNA. This binding event repositions and stabilizes these helices into an architecture that is optimal for the subsequent docking of SRP54, thereby ensuring the proper formation of a functional SRP complex essential for co‐translational targeting of secretory and membrane proteins."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to facilitating the proper RNA configuration for SRP54 binding, SRP19 plays an essential regulatory role in the assembly process by binding early to the SRP RNA. This early engagement prevents premature or aberrant association of SRP54, thereby protecting the RNA from adopting non‐native, misfolded conformations. Such controlled temporal ordering is critical to avoid the formation of defective ribonucleoprotein assemblies and guarantees the fidelity of the overall SRP biogenesis process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in SRP assembly, perturbations in SRP19 function have broader physiological implications. Altered expression or structure of SRP19 is associated with defects in co‐translational protein targeting that can impact processes such as neutrophil granulocyte differentiation. Moreover, in the context of autoimmune disease, autoantibodies against SRP19 are frequently detected in muscle tissues from patients with autoimmune necrotizing myopathy, implicating SRP19 in disease pathogenesis and highlighting its importance in cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "K Wild, I Sinning, S Cusack "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of an early protein-RNA assembly complex of the signal recognition particle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1063839"}], "href": "https://doi.org/10.1126/science.1063839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11641499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11641499"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tobias Hainzl, Shenghua Huang, A Elisabeth Sauer-Eriksson "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the SRP19 RNA complex and implications for signal recognition particle assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature00768"}], "href": "https://doi.org/10.1038/nature00768"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12050674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12050674"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Andreas Kuglstatter, Chris Oubridge, Kiyoshi Nagai "}, {"type": "b", "children": [{"type": "t", "text": "Induced structural changes of 7SL RNA during the assembly of human signal recognition particle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsb843"}], "href": "https://doi.org/10.1038/nsb843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12244299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12244299"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Klemens Wild, Gert Bange, Gunes Bozkurt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insights into the assembly of the human and archaeal signal recognition particles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Crystallogr D Biol Crystallogr (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1107/S0907444910000879"}], "href": "https://doi.org/10.1107/S0907444910000879"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20179341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20179341"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tuhin Subhra Maity, Kevin M Weeks "}, {"type": "b", "children": [{"type": "t", "text": "A threefold RNA-protein interface in the signal recognition particle gates native complex assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2007.03.032"}], "href": "https://doi.org/10.1016/j.jmb.2007.03.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17434535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17434535"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Q Wang, F Duan, P Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of anti-SRP19 antibody in muscle tissues from patients with autoimmune necrotizing myopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/gmr.15038307"}], "href": "https://doi.org/10.4238/gmr.15038307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27525944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27525944"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Monika I Linder, Yoko Mizoguchi, Sebastian Hesse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2022016783"}], "href": "https://doi.org/10.1182/blood.2022016783"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36223592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36223592"}]}]}]}
Proteins	SRP19_HUMAN
NCBI Gene ID	6728
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SRP19 has 5,827 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for SRP19 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SRP19 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by SRP19 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRP19 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRP19 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SRP19 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SRP19 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of SRP19 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRP19 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SRP19 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SRP19 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SRP19 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SRP19 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SRP19 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SRP19 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with SRP19 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SRP19 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SRP19 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SRP19 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SRP19 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SRP19 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SRP19 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SRP19 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SRP19 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SRP19 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SRP19 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SRP19 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SRP19 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SRP19 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SRP19 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of SRP19 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with SRP19 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SRP19 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SRP19 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SRP19 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SRP19 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SRP19 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SRP19 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SRP19 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SRP19 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with SRP19 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with SRP19 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.