SRPX2 Gene

Name	sushi-repeat containing protein, X-linked 2
Description	This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and cognitive disability. [provided by RefSeq, May 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSRPX2 is a secreted, sushi‐repeat–containing protein that plays a pivotal role in brain development. In the nervous system, it is expressed in neurons of regions critical for language and cognitive function, where it facilitates synaptogenesis, promotes proper neuronal migration, and is essential for normal speech acquisition and vocalization. SRPX2 mutations have been linked to rolandic epilepsy, speech dyspraxia, and cortical malformations, and its expression is regulated by key transcription factors such as FOXP2, which further underscores its involvement in a network crucial for neurodevelopment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn diverse malignancies, SRPX2 is frequently overexpressed and functions as a potent mediator of tumor progression. Elevated SRPX2 levels have been observed in gastric, colorectal, esophageal, hepatocellular, thyroid, non‐small cell lung, and oral squamous cell carcinomas. In these cancers, SRPX2 promotes cell migration, invasion, adhesion, and epithelial–mesenchymal transition by activating key signaling pathways such as FAK/AKT, Wnt/β‑catenin, and PI3K/AKT, and its dysregulation is often associated with unfavorable clinical outcomes. Epigenetic mechanisms and post‐transcriptional regulators (for example, aberrant promoter hypomethylation and reduced microRNA expression) further contribute to its elevated expression in tumors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in neurodevelopment and cancer, SRPX2 functions as a novel chondroitin sulfate proteoglycan that significantly influences extracellular matrix remodeling, angiogenesis, and tissue repair. By binding to the urokinase-type plasminogen activator receptor (uPAR) and cooperating with integrin receptors, SRPX2 modulates endothelial cell migration, tube formation, and the shedding of adhesion molecules, thereby contributing to new blood vessel formation. In fibrotic conditions such as idiopathic pulmonary fibrosis, SRPX2 also participates in a TGF‑β/SMAD3–driven positive feedback loop that promotes the fibroblast-to-myofibroblast transition, highlighting its potential as a therapeutic target in disorders characterized by aberrant tissue remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Patrice Roll, Gabrielle Rudolf, Sandrine Pereira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRPX2 mutations in disorders of language cortex and cognition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddl035"}], "href": "https://doi.org/10.1093/hmg/ddl035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16497722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16497722"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Barbara Royer, Dinesh C Soares, Paul N Barlow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2156-8-72"}], "href": "https://doi.org/10.1186/1471-2156-8-72"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17942002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17942002"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Barbara Royer-Zemmour, Magali Ponsole-Lenfant, Hyam Gara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddn256"}], "href": "https://doi.org/10.1093/hmg/ddn256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18718938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18718938"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Patrice Roll, Sonja C Vernes, Nadine Bruneau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq415"}], "href": "https://doi.org/10.1093/hmg/ddq415"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20858596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20858596"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "G M Sia, R L Clem, R L Huganir "}, {"type": "b", "children": [{"type": "t", "text": "The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1245079"}], "href": "https://doi.org/10.1126/science.1245079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24179158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24179158"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Schaida Schirwani, Vivienne McConnell, Josh Willoughby, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0027922"}], "href": "https://doi.org/10.1371/journal.pone.0027922"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22242148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22242148"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bodil Øster, Lene Linnet, Lise Lotte Christensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.27921"}], "href": "https://doi.org/10.1002/ijc.27921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23115050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23115050"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Takanobu Yamada, Takashi Oshima, Kazue Yoshihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of overexpression of Sushi repeat-containing protein X-linked 2 gene on outcomes of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Surg Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jso.23602"}], "href": "https://doi.org/10.1002/jso.23602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24700475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24700475"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "K L Liu, J Wu, Y Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Sushi repeat-containing protein X-linked 2 is associated with progression of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-015-0548-4"}], "href": "https://doi.org/10.1007/s12032-015-0548-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25737434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25737434"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiaobo Lin, Weiping Chang, Yuan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRPX2, an independent prognostic marker, promotes cell migration and invasion in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.06.075"}], "href": "https://doi.org/10.1016/j.biopha.2017.06.075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28654796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28654796"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Fei He, Haojie Wang, Yong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRPX2 knockdown inhibits cell proliferation and metastasis and promotes chemosensitivity in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.10.042"}], "href": "https://doi.org/10.1016/j.biopha.2018.10.042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30551519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30551519"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Tomonori Sasahira, Miyako Kurihara-Shimomura, Yukiko Nishiguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sushi Repeat Containing Protein X-linked 2 Is a Downstream Signal of LEM Domain Containing 1 and Acts as a Tumor-Promoting Factor in Oral Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21103655"}], "href": "https://doi.org/10.3390/ijms21103655"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32455867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32455867"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiujuan Li, Jing Liu, Hong Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRPX2 promotes cell proliferation and invasion via activating FAK/SRC/ERK pathway in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Pol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18388/abp.2020_5158"}], "href": "https://doi.org/10.18388/abp.2020_5158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32550700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32550700"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Haiwei Guo, Ruiqi Liu, Jiajun Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRPX2 promotes cancer cell proliferation and migration of papillary thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-023-01113-1"}], "href": "https://doi.org/10.1007/s10238-023-01113-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37306872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37306872"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Marijana Miljkovic-Licina, Philippe Hammel, Sarah Garrido-Urbani, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.61085"}], "href": "https://doi.org/10.7150/thno.61085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34093874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34093874"}]}]}]}
Synonyms	RESDX, CBPS, PMGX, BPP, SRPUL
Proteins	SRPX2_HUMAN
NCBI Gene ID	27286
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

SRPX2 has 5,675 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 115 datasets.

Click the + buttons to view associations for SRPX2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

SRPX2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRPX2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRPX2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of SRPX2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of SRPX2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of SRPX2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of SRPX2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SRPX2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of SRPX2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of SRPX2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of SRPX2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of SRPX2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with SRPX2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SRPX2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of SRPX2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of SRPX2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with SRPX2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with SRPX2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of SRPX2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing SRPX2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing SRPX2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing SRPX2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing SRPX2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with SRPX2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with SRPX2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of SRPX2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with SRPX2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with SRPX2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with SRPX2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with SRPX2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by SRPX2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving SRPX2 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving SRPX2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with SRPX2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with SRPX2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with SRPX2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with SRPX2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at SRPX2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of SRPX2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of SRPX2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing SRPX2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.