{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts mention a protein called “SRRD,” the collective studies instead illuminate the multifaceted functions of Bruton's tyrosine kinase (BTK) and its related Tec family members in immune regulation. In the adaptive immune compartment, BTK is indispensable for B‐cell receptor–mediated signaling that governs B cell development, survival, and differentiation. BTK links antigen engagement and co‐receptor (e.g., BAFF‐R) signals to activation of critical downstream effectors such as NF‑κB, MAPKs, and calcium flux that in turn regulate gene expression, cytoskeletal dynamics, and cell cycle progression. Dysregulation of BTK—whether by loss‐of‐function mutations or overexpression—can impair normal B cell maturation and tolerance, contributing to immunodeficiency on one hand or to autoimmune phenomena (including aberrant autoantibody production and systemic lupus erythematosus–like pathology) on the other."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the innate immune system, BTK and related kinases are shown to orchestrate a variety of functions in myeloid cells, neutrophils, osteoclasts, and platelets. BTK contributes to receptor-mediated activation in these cells—including signaling via toll-like receptors (TLRs) such as TLR3 and TLR9, as well as integrin activation downstream of selectins—thereby regulating cytokine production, phagocytosis, cell adhesion, and differentiation. For example, BTK participates in the formation of signaling complexes that modulate osteoclast fusion for bone resorption, aids in efficient phagocytic uptake and processing of pathogens, and helps control platelet activation and thrombus formation via regulation of phospholipase Cγ2 and calcium mobilization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these cell‐intrinsic signaling roles, additional regulatory mechanisms modulate BTK activity and thereby influence therapeutic outcomes. Studies reveal that post‐translational regulators—such as the peptidylprolyl isomerase Pin1—control BTK’s stability, while BTK itself can serve as a negative modulator of inflammasome assembly in macrophages. Moreover, BTK functions downstream of immunoregulatory receptors (for example, TIM‑3 in dendritic cells) and its inhibition—by compounds such as ibrutinib or acalabrutinib—not only blocks pathological B cell proliferation in chronic lymphocytic leukemia but also ameliorates inflammatory conditions like influenza-induced lung injury. Together, these insights underscore the potential of BTK as a therapeutic target in autoimmunity, malignancy, and inflammatory disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David A Fruman, Gregory Z Ferl, Sam S An, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Proteasome-dependent autoregulation of Bruton tyrosine kinase (Btk) promoter via NF-kappaB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-10-121137"}], "href": "https://doi.org/10.1182/blood-2007-10-121137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18292289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18292289"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Laurens P Kil, Marjolein J W de Bruijn, Menno van Nimwegen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-07-515361"}], "href": "https://doi.org/10.1182/blood-2013-07-515361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24311722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24311722"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Odilia B J Corneth, Marjolein J W de Bruijn, Jasper Rip, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced Expression of Bruton's Tyrosine Kinase in B Cells Drives Systemic Autoimmunity by Disrupting T Cell Homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1600208"}], "href": "https://doi.org/10.4049/jimmunol.1600208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27226091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27226091"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sarah E M Herman, Arnau Montraveta, Carsten U Niemann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-16-0463"}], "href": "https://doi.org/10.1158/1078-0432.CCR-16-0463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27903679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27903679"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sangita Mukhopadhyay, Madhuchhanda Mohanty, Anita Mangla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.168.6.2914"}], "href": "https://doi.org/10.4049/jimmunol.168.6.2914"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11884462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11884462"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ben T Atkinson, Wilfried Ellmeier, Steve P Watson "}, {"type": "b", "children": [{"type": "t", "text": "Tec regulates platelet activation by GPVI in the absence of Btk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2003-04-1142"}], "href": "https://doi.org/10.1182/blood-2003-04-1142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12842985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12842985"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Anita Mangla, Anupriya Khare, Varanasi Vineeth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-01-0207"}], "href": "https://doi.org/10.1182/blood-2004-01-0207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15117762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15117762"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Saida Ortolano, Il-Young Hwang, Sang-Bae Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200535799"}], "href": "https://doi.org/10.1002/eji.200535799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16619289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16619289"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Junling Liu, Malinda E Fitzgerald, Michael C Berndt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2006-01-011817"}], "href": "https://doi.org/10.1182/blood-2006-01-011817"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16788103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16788103"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Seoung Hoon Lee, Taesoo Kim, Daewon Jeong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M708935200"}], "href": "https://doi.org/10.1074/jbc.M708935200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18281276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18281276"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Masahiro Shinohara, Takako Koga, Kazuo Okamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2007.12.037"}], "href": "https://doi.org/10.1016/j.cell.2007.12.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18329366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18329366"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Shruti Sharma, Gregory Orlowski, Wenxia Song "}, {"type": "b", "children": [{"type": "t", "text": "Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.182.1.329"}], "href": "https://doi.org/10.4049/jimmunol.182.1.329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19109164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19109164"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Katja Fiedler, Anca Sindrilaru, Grzegorz Terszowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-04-281170"}], "href": "https://doi.org/10.1182/blood-2010-04-281170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21063022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21063022"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Koon-Guan Lee, Shengli Xu, Zi-Han Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1119238109"}], "href": "https://doi.org/10.1073/pnas.1119238109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22454496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22454496"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Karin Strijbis, Fikadu G Tafesse, Gregory D Fairn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1003446"}], "href": "https://doi.org/10.1371/journal.ppat.1003446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23825946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23825946"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Susanne Herbst, Anand Shah, Maria Mazon Moya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201404556"}], "href": "https://doi.org/10.15252/emmm.201404556"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25637383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25637383"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Andrew Stiff, Prashant Trikha, Robert Wesolowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-1490"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-1490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26880800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26880800"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Liang Yu, Abdalla J Mohamed, Leonardo Vargas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M603090200"}], "href": "https://doi.org/10.1074/jbc.M603090200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16644721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16644721"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "C Holden "}, {"type": "b", "children": [{"type": "t", "text": "Patuxent: controversial prison clings to belief in rehabilitation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (1978)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.199.4329.665"}], "href": "https://doi.org/10.1126/science.199.4329.665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17788103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17788103"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Pranav Murthy, Filip Durco, Jennifer L Miller-Ocuin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The NLRP3 inflammasome and bruton's tyrosine kinase in platelets co-regulate platelet activation, aggregation, and in vitro thrombus formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.12.161"}], "href": "https://doi.org/10.1016/j.bbrc.2016.12.161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28034752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28034752"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jon M Florence, Agnieszka Krupa, Laela M Booshehri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00047.2018"}], "href": "https://doi.org/10.1152/ajplung.00047.2018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29516781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29516781"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Liming Mao, Atsushi Kitani, Eitaro Hiejima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β-mediated colitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI128322"}], "href": "https://doi.org/10.1172/JCI128322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31895698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31895698"}]}]}]}