{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNA SRRM2-AS1 is highly expressed in nasopharyngeal carcinoma (NPC) tissues, where it plays a pivotal role in regulating cell proliferation, differentiation, and angiogenesis. In NPC, SRRM2-AS1 negatively modulates the expression of its target gene, myosin light chain kinase (MYLK), contributing to an environment characterized by increased vascular endothelial growth factor (VEGF) expression and elevated microvessel density."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nExperimental silencing of SRRM2-AS1 was shown to upregulate MYLK and activate the cGMP-PKG signaling pathway, leading to higher levels of cGMP and PKG. This molecular shift was accompanied by increased expression of pro-apoptotic markers such as Bax and Caspase 3, along with a reduction in proliferation markers including VEGF, PCNA, Ki-67, and the anti-apoptotic protein Bcl-2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctionally, the downregulation of SRRM2-AS1 curtails NPC cell proliferation, colony formation, and angiogenesis, while also inducing cell cycle arrest and promoting apoptosis. These findings underscore the therapeutic potential of targeting SRRM2-AS1 as a means to disrupt oncogenic signaling in NPC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shaoqing Chen, Linrong Lv, Zhengyu Zhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of long noncoding RNA SRRM2-AS exerts suppressive effects on angiogenesis in nasopharyngeal carcinoma via activating MYLK-mediated cGMP-PKG signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29382"}], "href": "https://doi.org/10.1002/jcp.29382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31742692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31742692"}]}]}]}