{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSerine/arginine‐rich splicing factor 1 (SRSF1), also known as SF2/ASF, is a multifunctional regulator of RNA metabolism whose primary role is to bind purine‐rich motifs in target pre‐mRNAs and thereby dictate alternative splice site selection. Fundamental studies have demonstrated that SRSF1 influences the inclusion or skipping of specific exons in diverse transcripts – from regulatory factors like the Gα(s) messenger to viral RNAs in human papillomavirus and HIV‐1 – while also modulating mRNA export and translation. Moreover, its proper function is essential for maintaining genomic stability by preventing aberrant R‐loop formation and ensuring efficient spliceosome assembly."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical functions in splicing, SRSF1 exerts widespread effects on gene expression that extend into translational control and oncogenic signaling. Investigations have revealed that SRSF1 modulates the alternative splicing of key apoptotic regulators such as caspase‐9 and components of cell cycle machinery like CDC2L5, while also engaging in autoregulatory feedback loops to fine‐tune its own expression. SRSF1 enhances cap‐dependent translation through interactions with mTOR and eIF4E and influences the formation of messenger ribonucleoprotein complexes in both the nucleus and cytoplasm. In addition, global mapping of its binding sites by cross‐linking immunoprecipitation has underscored its pervasive role in regulating a wide spectrum of mRNAs – a finding that provides mechanistic insights into its capacity to alter splicing networks, promote protein sumoylation, and coordinate early spliceosome assembly."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, SRSF1 plays context‐dependent roles in integrating cellular stress responses, viral RNA processing, and noncoding RNA–mediated regulation. In cancer cells, its overexpression reprograms the alternative splicing of transcripts that govern proliferation and apoptosis – favoring production of oncogenic isoforms and cooperating with factors like MYC – which has been observed in breast, lung, and colon tumors. SRSF1 also participates in the regulation of nuclear architecture and the dynamic assembly of nuclear speckles, responds to metabolic and oxidative stress by modulating autophagy, and influences neurodegeneration by controlling the nuclear export of toxic repeat–bearing transcripts. Studies in viral systems further illustrate its role as an adaptor that guides splicing of viral pre‐mRNAs and modulates enhancer functions that impact the replicative cycle."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alison J Pollard, Adrian R Krainer, Stephen C Robson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3'-splice Site."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109046200"}], "href": "https://doi.org/10.1074/jbc.M109046200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11825891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11825891"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Delphine Ropers, Lilia Ayadi, Renata Gattoni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M404452200"}], "href": "https://doi.org/10.1074/jbc.M404452200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15123677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15123677"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alain Expert-Bezançon, Alain Sureau, Patrice Durosay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M405377200"}], "href": "https://doi.org/10.1074/jbc.M405377200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15208309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15208309"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yingqun Huang, Therese A Yario, Joan A Steitz "}, {"type": "b", "children": [{"type": "t", "text": "A molecular link between SR protein dephosphorylation and mRNA export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0403533101"}], "href": "https://doi.org/10.1073/pnas.0403533101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15210956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15210956"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maria G McPhillips, Thanaporn Veerapraditsin, Sarah A Cumming, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SF2/ASF binds the human papillomavirus type 16 late RNA control element and is regulated during differentiation of virus-infected epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.78.19.10598-10605.2004"}], "href": "https://doi.org/10.1128/JVI.78.19.10598-10605.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15367627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15367627"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xialu Li, James L Manley "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2005.06.008"}], "href": "https://doi.org/10.1016/j.cell.2005.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16096057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16096057"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jeremy R Sanford, Jonathan D Ellis, Demian Cazalla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0507827102"}], "href": "https://doi.org/10.1073/pnas.0507827102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16210245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16210245"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xialu Li, Jin Wang, James L Manley "}, {"type": "b", "children": [{"type": "t", "text": "Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1359305"}], "href": "https://doi.org/10.1101/gad.1359305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16260492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16260492"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Autumn Massiello, Charles E Chalfant "}, {"type": "b", "children": [{"type": "t", "text": "SRp30a (ASF/SF2) regulates the alternative splicing of caspase-9 pre-mRNA and is required for ceramide-responsiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.C600003-JLR200"}], "href": "https://doi.org/10.1194/jlr.C600003-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16505493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16505493"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yasmine Even, Sandrine Durieux, Marie-Line Escande, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.20986"}], "href": "https://doi.org/10.1002/jcb.20986"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16721827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16721827"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Rotem Karni, Elisa de Stanchina, Scott W Lowe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The gene encoding the splicing factor SF2/ASF is a proto-oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb1209"}], "href": "https://doi.org/10.1038/nsmb1209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17310252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17310252"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xialu Li, Tianhui Niu, James L Manley "}, {"type": "b", "children": [{"type": "t", "text": "The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.734407"}], "href": "https://doi.org/10.1261/rna.734407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17959926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17959926"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hanae Sato, Nao Hosoda, Lynne E Maquat "}, {"type": "b", "children": [{"type": "t", "text": "Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.12.009"}], "href": "https://doi.org/10.1016/j.molcel.2007.12.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18243119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18243119"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Gracjan Michlewski, Jeremy R Sanford, Javier F Cáceres "}, {"type": "b", "children": [{"type": "t", "text": "The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.03.013"}], "href": "https://doi.org/10.1016/j.molcel.2008.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18439897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18439897"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Rotem Karni, Yoshitaka Hippo, Scott W Lowe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The splicing-factor oncoprotein SF2/ASF activates mTORC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0801376105"}], "href": "https://doi.org/10.1073/pnas.0801376105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18832178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18832178"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jeremy R Sanford, Xin Wang, Matthew Mort, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.082503.108"}], "href": "https://doi.org/10.1101/gr.082503.108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19116412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19116412"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Rebecca J Loomis, Yoshinori Naoe, J Brandon Parker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2009.02.003"}], "href": "https://doi.org/10.1016/j.molcel.2009.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19250906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19250906"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shuying Sun, Zuo Zhang, Rahul Sinha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1750"}], "href": "https://doi.org/10.1038/nsmb.1750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20139984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20139984"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Rahul Sinha, Eric Allemand, Zuo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01270-09"}], "href": "https://doi.org/10.1128/MCB.01270-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20308322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20308322"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Han Wu, Shuying Sun, Kang Tu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A splicing-independent function of SF2/ASF in microRNA processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2010.02.021"}], "href": "https://doi.org/10.1016/j.molcel.2010.02.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20385090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20385090"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Federico Pelisch, Juan Gerez, Jimena Druker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The serine/arginine-rich protein SF2/ASF regulates protein sumoylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1004653107"}], "href": "https://doi.org/10.1073/pnas.1004653107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20805487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20805487"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jacqueline C Shultz, Rachel W Goehe, D Shanaka Wijesinghe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-1545"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-1545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21045158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21045158"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Suhyung Cho, Amy Hoang, Rahul Sinha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1017700108"}], "href": "https://doi.org/10.1073/pnas.1017700108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21536904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21536904"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jacqueline C Shultz, Rachel W Goehe, Charuta S Murudkar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRSF1 regulates the alternative splicing of caspase 9 via a novel intronic splicing enhancer affecting the chemotherapeutic sensitivity of non-small cell lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-11-0061"}], "href": "https://doi.org/10.1158/1541-7786.MCR-11-0061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21622622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21622622"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Olga Anczuków, Avi Z Rosenberg, Martin Akerman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.2207"}], "href": "https://doi.org/10.1038/nsmb.2207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22245967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22245967"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Shipra Das, Olga Anczuków, Martin Akerman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2011.12.001"}], "href": "https://doi.org/10.1016/j.celrep.2011.12.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22545246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22545246"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Brandon E Aubol, Ryan M Plocinik, Jonathan C Hagopian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2013.05.013"}], "href": "https://doi.org/10.1016/j.jmb.2013.05.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23707382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23707382"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Fernando J de Miguel, Ravi D Sharma, María J Pajares, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of alternative splicing events regulated by the oncogenic factor SRSF1 in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-1481"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-1481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24371231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24371231"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Shipra Das, Adrian R Krainer "}, {"type": "b", "children": [{"type": "t", "text": "Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-14-0131"}], "href": "https://doi.org/10.1158/1541-7786.MCR-14-0131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24807918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24807918"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Junqing Wang, Liping Su, Xuehua Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2014.04.007"}], "href": "https://doi.org/10.1016/j.biopha.2014.04.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24857172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24857172"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Olga Anczuków, Martin Akerman, Antoine Cléry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRSF1-Regulated Alternative Splicing in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.09.005"}], "href": "https://doi.org/10.1016/j.molcel.2015.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26431027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26431027"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Liyan Jiang, Jiaqi Huang, Brandon W Higgs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1005895"}], "href": "https://doi.org/10.1371/journal.pgen.1005895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27093186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27093186"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Guillaume M Hautbergue, Lydia M Castelli, Laura Ferraiuolo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms16063"}], "href": "https://doi.org/10.1038/ncomms16063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28677678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28677678"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Xuexia Zhou, Run Wang, Xuebing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI120279"}], "href": "https://doi.org/10.1172/JCI120279"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30481162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30481162"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Hongda Liu, Zheng Gong, Kangshuai Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-021-01877-y"}], "href": "https://doi.org/10.1186/s13046-021-01877-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33602301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33602301"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Yuesheng Lv, Wenjing Zhang, Jinyao Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Signal Transduct Target Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41392-021-00495-6"}], "href": "https://doi.org/10.1038/s41392-021-00495-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33664238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33664238"}]}]}]}