SSTR4 Gene

HGNC Family G protein-coupled receptors
Name somatostatin receptor 4
Description Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSSTR4, one of the five G protein–coupled somatostatin receptors, exhibits a heterogeneous expression profile in both endocrine tumors and non‐tumoral tissues. In gastroenteropancreatic endocrine tumors, for example, SSTR4 is identified only in a small minority of cases (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Its expression has also been investigated in prostate tissue, where in situ analyses have sought to clarify its presence alongside other receptor subtypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In conditions such as Graves’ ophthalmopathy, SSTR4 mRNA is found at relatively higher levels in retroorbital lymphocytes from affected patients compared to controls"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and similar profiling has been noted in fibroblasts derived from retroorbital tissue."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Additionally, studies in gallbladder and laryngeal carcinomas indicate that altered SSTR4 expression may correlate with disease characteristics such as lymphatic spread"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in pituitary adenomas it is among the less abundantly expressed subtypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies in cellular models have elucidated key aspects of SSTR4 function. Experiments using HEK-293 cells demonstrate that human SSTR4 undergoes constitutive dimerization—a process crucially dependent on the receptor’s intact C-terminal tail—for proper membrane expression and efficient coupling to inhibitory G proteins. This coupling underlies its ability to reduce cyclic AMP levels and modulate downstream MAPK signaling (notably pERK1/2 and pERK5), which is associated with upregulation of cyclin-dependent kinase inhibitor p27(kip1) and subsequent inhibition of cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in cell signaling and growth regulation, SSTR4 is emerging as a key mediator in both peripheral inflammatory responses and central nervous system (CNS) modulation. In the lung, SSTR4 is localized on bronchial epithelial cells, vascular endothelium, and smooth muscle cells, and its protein levels markedly increase in response to inflammatory challenges such as endotoxin exposure and chronic cigarette smoke—effects that are largely attributable to the recruitment of sst4‐positive mononuclear cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In the CNS, SSTR4 is predominantly expressed in glutamatergic neurons within pain and mood regulatory circuits, and activation of the receptor reliably decreases neuronal firing by enhancing the M-current, supporting its potential as a novel target for analgesic and antidepressant therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Notably, investigations into its gene regulation reveal that the methylation status of the SSTR4 promoter remains largely unaltered in Alzheimer’s disease, suggesting that dysregulation of SSTR4 signaling in neurodegeneration is not primarily driven by promoter hypermethylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Papotti, M Bongiovanni, M Volante, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virchows Arch (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00428-002-0609-x"}], "href": "https://doi.org/10.1007/s00428-002-0609-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12021920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12021920"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jens Hansson, Anders Bjartell, Virgil Gadaleanu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of somatostatin receptor subtypes 2 and 4 in human benign prostatic hyperplasia and prostatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.10121"}], "href": "https://doi.org/10.1002/pros.10121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12210479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12210479"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Daniela Pasquali, Antonio Notaro, Giulio Bonavolonta', et al. "}, {"type": "b", "children": [{"type": "t", "text": "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2002-020790"}], "href": "https://doi.org/10.1210/jc.2002-020790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12414882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12414882"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "D Pasquali, A Notaro, D Esposito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Minerva Endocrinol (2001)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11753241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11753241"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Run-Sheng Guo, Pei-Dong Shi, Jie Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Somatostatin receptors 3, 4 and 5 play important roles in gallbladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2013.14.7.4071"}], "href": "https://doi.org/10.7314/apjcp.2013.14.7.4071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23991955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23991955"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Luke T Condon, Nicholas D Stafford, Karen J Bedford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of somatostatin receptors 3, 4 and 5 in laryngeal pathology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Arch Otorhinolaryngol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00405-007-0539-y"}], "href": "https://doi.org/10.1007/s00405-007-0539-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18066572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18066572"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ana Paula M Casarini, Raquel S Jallad, Emília M Pinto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acromegaly: correlation between expression of somatostatin receptor subtypes and response to octreotide-lar treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pituitary (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11102-009-0175-1"}], "href": "https://doi.org/10.1007/s11102-009-0175-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19330452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19330452"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rishi K Somvanshi, Sabina Billova, Geetanjali Kharmate, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C-tail mediated modulation of somatostatin receptor type-4 homo- and heterodimerizations and signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2009.04.007"}], "href": "https://doi.org/10.1016/j.cellsig.2009.04.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19426801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19426801"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zoltán Varecza, Krisztián Elekes, Terézia László, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the somatostatin receptor subtype 4 in intact and inflamed pulmonary tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Histochem Cytochem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1369/jhc.2009.953919"}], "href": "https://doi.org/10.1369/jhc.2009.953919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19687471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19687471"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Angéla Kecskés, Krisztina Pohóczky, Miklós Kecskés, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21207788"}], "href": "https://doi.org/10.3390/ijms21207788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33096776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33096776"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Christian Grosser, Lisa Neumann, Bernhard Horsthemke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation analysis of SST and SSTR4 promoters in the neocortex of Alzheimer's disease patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2014.02.046"}], "href": "https://doi.org/10.1016/j.neulet.2014.02.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24602981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24602981"}]}]}]}
Synonyms SS4-R, SS-4-R, SS4R
Proteins SSR4_HUMAN
NCBI Gene ID 6754
API
Download Associations
Predicted Functions View SSTR4's ARCHS4 Predicted Functions.
Co-expressed Genes View SSTR4's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View SSTR4's ARCHS4 Predicted Functions.

Functional Associations

SSTR4 has 3,514 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 90 datasets.

Click the + buttons to view associations for SSTR4 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SSTR4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of SSTR4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of SSTR4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of SSTR4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of SSTR4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SSTR4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of SSTR4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of SSTR4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of SSTR4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SSTR4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of SSTR4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of SSTR4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SSTR4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing SSTR4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing SSTR4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with SSTR4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with SSTR4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of SSTR4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with SSTR4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with SSTR4 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with SSTR4 gene/protein from the curated CTD Gene-Disease Associations dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by SSTR4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with SSTR4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with SSTR4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with SSTR4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with SSTR4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with SSTR4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SSTR4 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of SSTR4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of SSTR4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing SSTR4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with SSTR4 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with SSTR4 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of SSTR4 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with SSTR4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing SSTR4 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of SSTR4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SSTR4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of SSTR4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of SSTR4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of SSTR4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of SSTR4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving SSTR4 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving SSTR4 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving SSTR4 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing SSTR4 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing SSTR4 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing SSTR4 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by SSTR4 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by SSTR4 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by SSTR4 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of SSTR4 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of SSTR4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of SSTR4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
Guide to Pharmacology Chemical Ligands of Receptors ligands (chemical) binding SSTR4 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.
Guide to Pharmacology Protein Ligands of Receptors ligands (protein) binding SSTR4 receptor from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of SSTR4 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of SSTR4 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with SSTR4 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by SSTR4 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for SSTR4 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of SSTR4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEGG Pathways pathways involving SSTR4 protein from the KEGG Pathways dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of SSTR4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of SSTR4 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LOCATE Curated Protein Localization Annotations cellular components containing SSTR4 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain SSTR4 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by SSTR4 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of SSTR4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by SSTR4 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of SSTR4 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
PANTHER Pathways pathways involving SSTR4 protein from the PANTHER Pathways dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for SSTR4 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of SSTR4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of SSTR4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving SSTR4 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving SSTR4 protein from the Wikipathways PFOCR 2024 dataset.
Reactome Pathways 2014 pathways involving SSTR4 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving SSTR4 protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of SSTR4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at SSTR4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of SSTR4 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of SSTR4 gene from the RummaGEO Gene Perturbation Signatures dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of SSTR4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of SSTR4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of SSTR4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with SSTR4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with SSTR4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving SSTR4 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving SSTR4 protein from the WikiPathways Pathways 2024 dataset.