{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNAs have emerged as key regulators in tumorigenesis, and among them the lncRNA SSTR5‐AS1 – transcribed antisense to the somatostatin receptor 5 gene – has been implicated in multiple cancers. Although a study profiling lncRNAs in metastatic laryngeal squamous cell carcinoma underscored the overall importance of lncRNAs in cancer progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", SSTR5‐AS1 has been specifically highlighted in other malignancies. In hepatitis B virus–induced hepatocellular carcinoma, SSTR5‐AS1 was integrated into a competing endogenous RNA network where it formed an axis with hsa‐miR‐15b‐5p and carbonic anhydrase 2 (CA2), suggesting that it may influence key processes such as the p53 signaling cascade and nitrogen metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gallbladder carcinoma, increased expression of SSTR5‐AS1 was associated with gemcitabine resistance, as it promotes chemoresistance by inhibiting apoptosis. Mechanistically, SSTR5‐AS1 binds to NONO, protecting it from proteasomal degradation and thereby sustaining its pro‐survival effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in gastric cancer, investigation into SSTR5‐AS1 suggests a contributory role in tumor pathogenesis, thus reinforcing its potential as an oncogenic player."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther extending its oncogenic profile, SSTR5‐AS1 is upregulated in esophageal cancer where elevated levels correlate with poorer overall survival and enhanced tumor cell proliferation, underscoring its potential as both a prognostic and diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In prostate cancer, higher SSTR5‐AS1 expression is linked with advanced clinical features—including elevated prostate-specific antigen levels, higher tumor stage, and lymph node metastasis—and functionally contributes to cellular proliferation, migration, and invasion through modulation of epithelial–mesenchymal transition markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these findings indicate that SSTR5‐AS1 plays a multifaceted oncogenic role across diverse cancer types, acting through mechanisms that involve ceRNA regulation, modulation of apoptotic pathways, and promotion of aggressive phenotypes.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Baoshan Wang, Lei Zhao, Weiwei Chi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "SSTR5‑AS1 functions as a ceRNA to regulate CA2 by sponging miR‑15b‑5p for the development and prognosis of HBV‑related hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10736"}], "href": "https://doi.org/10.3892/mmr.2019.10736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31638225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31638225"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhuowei Xue, Bikang Yang, Qinyang Xu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "lncRNA SSTR5-AS1 Predicts Poor Prognosis and Contributes to the Progression of Esophageal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2023/5025868"}], "href": "https://doi.org/10.1155/2023/5025868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36726845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36726845"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shuai Yuan, Jianlong Bi, Yangang Zhang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SSTR5-AS1 as a Prognostic Marker Promotes Cell Proliferation and Epithelial-to-Mesenchymal Transition in Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2022042183"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2022042183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36734853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36734853"}]}]}]}