{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSSX2IP was first identified through protein–protein interaction screens as a novel binding partner of the SSX family, notably interacting with SSX2 via its N‐terminal moiety and colocalizing with it in the nucleus. Its discovery alongside other interactors, such as RAB3IP, provided early clues that SSX2IP might participate in regulating transcriptional repression and nuclear events. In rodent models, the homolog ADIP has been implicated in cell adhesion and migration, suggesting that SSX2IP may also influence cellular dynamics in both normal and malignant conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSubsequent research has uncovered critical cytoplasmic roles for SSX2IP as a centriolar satellite protein. In human and murine ciliated cells, SSX2IP localizes at the basal body of primary cilia where it is required for the recruitment of Cep290, a key component in the gating of ciliary proteins, and for the efficient targeting of the BBSome and Rab8—events necessary for cilia growth and membrane composition. In addition, SSX2IP (also referred to as hMsd1/SSX2IP) contributes to microtubule anchoring at the centrosome and to the integrity of centriole assembly. Its interaction with partners such as Wdr8 and its recruitment by OCRL further underscore a pivotal role in controlling spindle length and orientation as well as in maintaining proper microtubule‐organizing center function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMore recent studies have connected aberrant SSX2IP expression with oncogenesis. Elevated levels of SSX2IP have been correlated with aggressive tumor features and poor clinical outcomes in nasopharyngeal carcinoma, highlighting its potential as both a prognostic biomarker and therapeutic target. Moreover, emerging evidence implicates the miRNA‐181b‐5p/SSX2IP regulatory axis in acute lymphoblastic leukemia, emphasizing its significance in cancer progression and underscoring the multifaceted roles of SSX2IP in both the regulation of cell adhesion/migration and in the maintenance of centrosome function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Diederik R H de Bruijn, Nuno R dos Santos, Ellen Kater-Baats, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.10073"}], "href": "https://doi.org/10.1002/gcc.10073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12007189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12007189"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pu Li, Ying Lin, Yu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SSX2IP promotes metastasis and chemotherapeutic resistance of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1479-5876-11-52"}], "href": "https://doi.org/10.1186/1479-5876-11-52"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23452395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23452395"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maren Klinger, Wenbo Wang, Stefanie Kuhns, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E13-09-0526"}], "href": "https://doi.org/10.1091/mbc.E13-09-0526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24356449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24356449"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Akiko Hori, Christopher J Peddie, Lucy M Collinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Centriolar satellite- and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E14-11-1561"}], "href": "https://doi.org/10.1091/mbc.E14-11-1561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25833712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25833712"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Akiko Hori, Agathe Morand, Chiho Ikebe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.10.169"}], "href": "https://doi.org/10.1016/j.bbrc.2015.10.169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26545777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26545777"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Biao Wang, Wei He, Philipp P Prosseda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.202052173"}], "href": "https://doi.org/10.15252/embr.202052173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33987909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33987909"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhenzhen Chu, Oliver J Gruss "}, {"type": "b", "children": [{"type": "t", "text": "Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "cep135"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Knockout Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells11071189"}], "href": "https://doi.org/10.3390/cells11071189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35406752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35406752"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shih-Lun Chang, Sung-Wei Lee, Sheau-Fang Yang, et al. 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