| Name | stabilin 2 |
| Description | This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTAB2 (also known as HARE) plays a central role in host homeostasis by mediating the rapid clearance of unwanted or “altered‐self” macromolecules and cells. In professional and non‐professional phagocytes such as macrophages or liver sinusoidal endothelial cells, STAB2 binds externalized phosphatidylserine on apoptotic and necrotic cells, thereby facilitating efficient phagocytosis and triggering anti‐inflammatory responses (for example, via IL‑10 or TGF‑β production). In addition, its cytoplasmic domain interacts with adaptor proteins (e.g. GULP and thymosin β4) to orchestrate downstream signaling pathways required for cytoskeletal rearrangement and cell–cell communication in the clearance process."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n \nSTAB2 also acts as a versatile scavenger receptor for several glycosaminoglycans such as hyaluronan, chondroitin sulfates, and heparin. Expressed in two main isoforms—a full‐length receptor (Stab2) and a proteolytically processed C‑terminal half (HARE)—its extracellular Link domain and distinctive fasciclin and EGF‐like modules mediate high‑affinity binding of multiple ligands, which are then internalized via clathrin‑coated pits. This ligand uptake not only removes circulating extracellular matrix turnover products and pro‑inflammatory molecules but also initiates intracellular cascades (e.g. ERK1/2 and NF‑κB activation) that may inform tissue status. Moreover, structural features such as specific N‑glycan modifications and the presence of multiple endocytic motifs further refine receptor–ligand interactions and downstream signaling events, ensuring simultaneous binding of several ligands."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "21"}]}, {"type": "t", "text": "\n \nBeyond its scavenging role, STAB2 contributes to the regulation of hemostasis and immune modulation. Receptor‐mediated endocytosis of the von Willebrand factor–factor VIII complex regulates circulating levels of these clotting proteins, with genetic variants in STAB2 being linked to altered thrombotic risk. In parallel, alternative splicing and tissue‑specific receptor expression further diversify its function, and aberrantly high STAB2 expression has been implicated in cancer progression, while competitive ligand binding (e.g. oxidized albumin or antisense oligonucleotides) may modulate receptor endocytic capacity and inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S-Y Park, M-Y Jung, H-J Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.cdd.4402242"}], "href": "https://doi.org/10.1038/sj.cdd.4402242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17962816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17962816"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Seung-Yoon Park, Kae-Bok Kang, Narendra Thapa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709105200"}], "href": "https://doi.org/10.1074/jbc.M709105200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18230608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18230608"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sung-Jin Lee, In-Seop So, Seung-Yoon Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2008.03.058"}], "href": "https://doi.org/10.1016/j.febslet.2008.03.058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18519035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18519035"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Seung-Yoon Park, So-Youn Kim, Mi-Yeon Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epidermal growth factor-like domain repeat of stabilin-2 recognizes phosphatidylserine during cell corpse clearance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01993-07"}], "href": "https://doi.org/10.1128/MCB.01993-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18573870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18573870"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Soyoun Kim, Seung-Yoon Park, Sang-Yeob Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cross talk between engulfment receptors stabilin-2 and integrin αvβ5 orchestrates engulfment of phosphatidylserine-exposed erythrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.06743-11"}], "href": "https://doi.org/10.1128/MCB.06743-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22566688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22566688"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shilpa D'Souza, Seung-Yoon Park, In-San Kim "}, {"type": "b", "children": [{"type": "t", "text": "Stabilin-2 acts as an engulfment receptor for the phosphatidylserine-dependent clearance of primary necrotic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.01.133"}], "href": "https://doi.org/10.1016/j.bbrc.2013.01.133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23416077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23416077"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Han-Seul Jo, Ha-Jeong Kim "}, {"type": "b", "children": [{"type": "t", "text": "Stabilin-2 mediated apoptotic cell phagocytosis induces interleukin-10 expression by p38 and Pbx1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Biophys (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12013-024-01243-7"}], "href": "https://doi.org/10.1007/s12013-024-01243-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38480573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38480573"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Oliver Politz, Alexei Gratchev, Peter A G McCourt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/0264-6021:3620155"}], "href": "https://doi.org/10.1042/0264-6021:3620155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11829752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11829752"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Edward N Harris, Svetlana V Kyosseva, Janet A Weigel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M607787200"}], "href": "https://doi.org/10.1074/jbc.M607787200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17145755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17145755"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Edward N Harris, Janet A Weigel, Paul H Weigel "}, {"type": "b", "children": [{"type": "t", "text": "The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M710360200"}], "href": "https://doi.org/10.1074/jbc.M710360200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18434317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18434317"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Edward N Harris, Paul H Weigel "}, {"type": "b", "children": [{"type": "t", "text": "The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glycobiology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/glycob/cwn045"}], "href": "https://doi.org/10.1093/glycob/cwn045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18499864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18499864"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Edward N Harris, Janet A Weigel, Paul H Weigel "}, {"type": "b", "children": [{"type": "t", "text": "Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M405322200"}], "href": "https://doi.org/10.1074/jbc.M405322200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15208308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15208308"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Madhu S Pandey, Edward N Harris, Janet A Weigel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cytoplasmic domain of the hyaluronan receptor for endocytosis (HARE) contains multiple endocytic motifs targeting coated pit-mediated internalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M800886200"}], "href": "https://doi.org/10.1074/jbc.M800886200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18539600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18539600"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Madhu S Pandey, Bruce A Baggenstoss, Jennifer Washburn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The hyaluronan receptor for endocytosis (HARE) activates NF-κB-mediated gene expression in response to 40-400-kDa, but not smaller or larger, hyaluronans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.442889"}], "href": "https://doi.org/10.1074/jbc.M112.442889"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23530033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23530033"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Svetlana V Kyosseva, Edward N Harris, Paul H Weigel "}, {"type": "b", "children": [{"type": "t", "text": "The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709921200"}], "href": "https://doi.org/10.1074/jbc.M709921200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18387958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18387958"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Madhu S Pandey, Paul H Weigel "}, {"type": "b", "children": [{"type": "t", "text": "Hyaluronic acid receptor for endocytosis (HARE)-mediated endocytosis of hyaluronan, heparin, dermatan sulfate, and acetylated low density lipoprotein (AcLDL), but not chondroitin sulfate types A, C, D, or E, activates NF-κB-regulated gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.510339"}], "href": "https://doi.org/10.1074/jbc.M113.510339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24247245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24247245"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Edward N Harris, Bruce A Baggenstoss, Paul H Weigel "}, {"type": "b", "children": [{"type": "t", "text": "Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.90717.2008"}], "href": "https://doi.org/10.1152/ajpgi.90717.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19359419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19359419"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Edward N Harris, Simon Parry, Mark Sutton-Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-Glycans on the link domain of human HARE/Stabilin-2 are needed for hyaluronan binding to purified ecto-domain, but not for cellular endocytosis of hyaluronan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glycobiology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/glycob/cwq057"}], "href": "https://doi.org/10.1093/glycob/cwq057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20466649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20466649"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hans Gaus, Colton M Miller, Punit P Seth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.8b00126"}], "href": "https://doi.org/10.1021/acs.biochem.8b00126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29589907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29589907"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Paul H Weigel "}, {"type": "b", "children": [{"type": "t", "text": "Discovery of the Liver Hyaluronan Receptor for Endocytosis (HARE) and Its Progressive Emergence as the Multi-Ligand Scavenger Receptor Stabilin-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom9090454"}], "href": "https://doi.org/10.3390/biom9090454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31500161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31500161"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Madhu S Pandey, Colton M Miller, Edward N Harris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of ERK and NF-κB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0154124"}], "href": "https://doi.org/10.1371/journal.pone.0154124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27100626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27100626"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Laura L Swystun, Jesse D Lai, Colleen Notley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI96400"}], "href": "https://doi.org/10.1172/JCI96400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30124466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30124466"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Karl C Desch, Ayse B Ozel, Matt Halvorsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-exome sequencing identifies rare variants in STAB2 associated with venous thromboembolic disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2019004161"}], "href": "https://doi.org/10.1182/blood.2019004161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32457982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32457982"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Amanda K Hare, Edward N Harris "}, {"type": "b", "children": [{"type": "t", "text": "Tissue-specific splice variants of HARE/Stabilin-2 are expressed in bone marrow, lymph node, and spleen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.11.068"}], "href": "https://doi.org/10.1016/j.bbrc.2014.11.068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25446080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25446080"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Juanjuan Yong, Liyun Huang, Gengbiao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of Stabilin-2 predicts poor prognosis in non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1943109"}], "href": "https://doi.org/10.1080/21655979.2021.1943109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34227915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34227915"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Christopher Holte, Karolina Szafranska, Larissa Kruse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Highly oxidized albumin is cleared by liver sinusoidal endothelial cells via the receptors stabilin-1 and -2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-46462-9"}], "href": "https://doi.org/10.1038/s41598-023-46462-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37926735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37926735"}]}]}]}
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| Synonyms | SCARH1, FEEL2, FELL2, HARE, FEX2, FELE-2 |
| Proteins | STAB2_HUMAN |
| NCBI Gene ID | 55576 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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STAB2 has 4,830 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.
Click the + buttons to view associations for STAB2 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of STAB2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of STAB2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of STAB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of STAB2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of STAB2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of STAB2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of STAB2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of STAB2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of STAB2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of STAB2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with STAB2 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of STAB2 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of STAB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of STAB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of STAB2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing STAB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing STAB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing STAB2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with STAB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with STAB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of STAB2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with STAB2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with STAB2 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with STAB2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by STAB2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with STAB2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with STAB2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with STAB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with STAB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with STAB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with STAB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| DrugBank Drug Targets | interacting drugs for STAB2 protein from the curated DrugBank Drug Targets dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at STAB2 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of STAB2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of STAB2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing STAB2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with STAB2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with STAB2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of STAB2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with STAB2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing STAB2 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of STAB2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of STAB2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of STAB2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of STAB2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of STAB2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of STAB2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving STAB2 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving STAB2 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving STAB2 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing STAB2 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing STAB2 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing STAB2 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by STAB2 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by STAB2 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by STAB2 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of STAB2 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of STAB2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of STAB2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of STAB2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of STAB2 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with STAB2 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with STAB2 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with STAB2 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with STAB2 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of STAB2 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for STAB2 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of STAB2 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of STAB2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of STAB2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of STAB2 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for STAB2 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with STAB2 gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with STAB2 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with STAB2 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with STAB2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for STAB2 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of STAB2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of STAB2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of STAB2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving STAB2 protein from the KEGG Pathways 2026 dataset. | |
| Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate STAB2 protein from the Kinase Library Serine Threonine Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of STAB2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of STAB2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with STAB2 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of STAB2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of STAB2 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain STAB2 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by STAB2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of STAB2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of STAB2 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by STAB2 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of STAB2 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NURSA Protein Complexes | protein complexs containing STAB2 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for STAB2 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of STAB2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of STAB2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving STAB2 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving STAB2 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving STAB2 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving STAB2 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of STAB2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at STAB2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of STAB2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of STAB2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of STAB2 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of STAB2 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of STAB2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of STAB2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of STAB2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of STAB2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of STAB2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with STAB2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with STAB2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
