STAG3 Gene

Name	stromal antigen 3
Description	The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTAG3 encodes a meiosis‐specific cohesin subunit that is essential for sister chromatid cohesion during gametogenesis. Its proper function ensures accurate homologous chromosome pairing and segregation during meiosis, and loss‐of‐function mutations—including frameshift, splice‐site, and missense variants—have been robustly associated with reproductive failure. In females, pathogenic STAG3 variants cause premature ovarian failure characterized by primary amenorrhea and disrupted ovarian development, while in males, variants have been implicated in non‐obstructive azoospermia, highlighting its critical role in both oogenesis and spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in gametogenesis, experimental studies have elucidated key mechanistic aspects of STAG3 function. When co‐expressed with the meiosis‐specific kleisin Rec8 in somatic cells, STAG3 facilitates its nuclear import and chromatin loading, functionally replacing mitotic cohesin components and reinforcing sister chromatid cohesion. These insights have not only shed light on the molecular underpinnings of meiotic chromosome cohesion but have also supported the development and diagnostic use of targeted gene panels in evaluating cases of non‐obstructive azoospermia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its fundamental role in meiosis, aberrant expression or genomic alterations in STAG3 have emerged as contributors to cancer pathogenesis. Elevated STAG3 levels in colorectal cancer have been linked to aggressive tumor behavior, chemoresistance, and poor prognosis, while loss‐of–function events in STAG3 in melanoma cells have been associated with resistance to BRAF inhibitors via reactivation of MAPK signaling. Similarly, allele‐specific imbalances and somatic alterations of STAG3 have been observed in epithelial ovarian cancer, and recent data also suggest a potential oncogenic role in hepatocellular carcinoma. These findings underscore that, although primarily a meiotic factor, misregulation of STAG3 can disrupt chromosomal stability and signaling pathways that contribute to tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandrine Caburet, Valerie A Arboleda, Elena Llano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant cohesin in premature ovarian failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa1309635"}], "href": "https://doi.org/10.1056/NEJMoa1309635"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24597867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24597867"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Polona Le Quesne Stabej, Hywel J Williams, Chela James, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAG3 truncating variant as the cause of primary ovarian insufficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2015.107"}], "href": "https://doi.org/10.1038/ejhg.2015.107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26059840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26059840"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "W-B He, S Banerjee, L-L Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-exome sequencing identifies a homozygous donor splice-site mutation in STAG3 that causes primary ovarian insufficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13034"}], "href": "https://doi.org/10.1111/cge.13034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28393351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28393351"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yeojung Nam, Kyung Min Kang, Se Ra Sung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The association of stromal antigen 3 (STAG3) sequence variations with spermatogenic impairment in the male Korean population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian J Androl (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/aja.aja_28_19"}], "href": "https://doi.org/10.4103/aja.aja_28_19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31115363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31115363"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "A Riera-Escamilla, A Enguita-Marruedo, D Moreno-Mendoza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequencing of a 'mouse azoospermia' gene panel in azoospermic men: identification of RNF212 and STAG3 mutations as novel genetic causes of meiotic arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/dez042"}], "href": "https://doi.org/10.1093/humrep/dez042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31125047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31125047"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Abdelkader Heddar, Philippe Dessen, Delphine Flatters, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel STAG3 mutations in a Caucasian family with primary ovarian insufficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00438-019-01594-4"}], "href": "https://doi.org/10.1007/s00438-019-01594-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31363903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31363903"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "N van der Bijl, A Röpke, U Biswas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the stromal antigen 3 (STAG3) gene cause male infertility due to meiotic arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/dez204"}], "href": "https://doi.org/10.1093/humrep/dez204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31682730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31682730"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sylvie Jaillard, Kenneth McElreavy, Gorjana Robevska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAG3 homozygous missense variant causes primary ovarian insufficiency and male non-obstructive azoospermia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gaaa050"}], "href": "https://doi.org/10.1093/molehr/gaaa050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32634216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32634216"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wen Liu, Xuan Gao, Haobo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of STAG3 variants in Chinese non-obstructive azoospermia patients with germ cell maturation arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-89559-9"}], "href": "https://doi.org/10.1038/s41598-021-89559-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33980954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33980954"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Leigh A M Demain, Eline Boetje, Jonathan J Edgerley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biallelic loss of function variants in STAG3 result in primary ovarian insufficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biomed Online (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.rbmo.2021.07.003"}], "href": "https://doi.org/10.1016/j.rbmo.2021.07.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34497033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34497033"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Simona Mellone, Marco Zavattaro, Denise Vurchio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Long Contiguous Stretch of Homozygosity Disclosed a Novel "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "STAG3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Biallelic Pathogenic Variant Causing Primary Ovarian Insufficiency: A Case Report and Review of the Literature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes12111709"}], "href": "https://doi.org/10.3390/genes12111709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34828315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34828315"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Susana Gómez-Rojas, Jorge Enrique Aristizábal-Duque, Luisa Fernanda Muñoz-Fernández, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New STAG3 gene variant as a cause of premature ovarian insufficiency"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Rev Colomb Obstet Ginecol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18597/rcog.3806"}], "href": "https://doi.org/10.18597/rcog.3806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35503298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35503298"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Peter G Wolf, Alexander Cuba Ramos, Julia Kenzel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.212100"}], "href": "https://doi.org/10.1242/jcs.212100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29724914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29724914"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Thomas D Barber, Kirk McManus, Karen W Y Yuen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0712384105"}], "href": "https://doi.org/10.1073/pnas.0712384105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18299561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18299561"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lydia Quaye, Dimitra Dafou, Susan J Ramus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp107"}], "href": "https://doi.org/10.1093/hmg/ddp107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19270026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19270026"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Maria Notaridou, Lydia Quaye, Dimitra Dafou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.25554"}], "href": "https://doi.org/10.1002/ijc.25554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20635389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20635389"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Che-Hung Shen, Sun Hye Kim, Sebastian Trousil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.4155"}], "href": "https://doi.org/10.1038/nm.4155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27500726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27500726"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Masaru Sasaki, Norikatsu Miyoshi, Shiki Fujino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The meiosis-specific cohesin component stromal antigen 3 promotes cell migration and chemotherapeutic resistance in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2020.10.006"}], "href": "https://doi.org/10.1016/j.canlet.2020.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33039558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33039558"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Menglin Zhao, Yanyan Wang, Yue Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Gastroenterol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12876-022-02400-z"}], "href": "https://doi.org/10.1186/s12876-022-02400-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35941537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35941537"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jianmei Yi, Feng Peng, Jingli Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-44379-x"}], "href": "https://doi.org/10.1038/s41598-023-44379-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37828232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37828232"}]}]}]}
Proteins	STAG3_HUMAN
NCBI Gene ID	10734
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

STAG3 has 6,078 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for STAG3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

STAG3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STAG3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of STAG3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of STAG3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of STAG3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of STAG3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STAG3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of STAG3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STAG3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STAG3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of STAG3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of STAG3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of STAG3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with STAG3 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with STAG3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STAG3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of STAG3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of STAG3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with STAG3 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with STAG3 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of STAG3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of STAG3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing STAG3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing STAG3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing STAG3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with STAG3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with STAG3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing STAG3 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of STAG3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with STAG3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with STAG3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by STAG3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for STAG3 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving STAG3 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving STAG3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with STAG3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with STAG3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with STAG3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with STAG3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with STAG3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at STAG3 gene from the ENCODE Histone Modification Site Profiles dataset.