{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent eQTL studies in osteoclasts have revealed that genetic variation at the Paget’s disease–associated locus correlates with altered expression of STMP1, suggesting that STMP1 may play a regulatory role in bone cell function and skeletal remodeling. These findings imply that even though the functional details of STMP1 in bone metabolism remain to be fully elucidated, its expression is genetically linked to osteoclast biology and bone disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of microbial pathogenesis, Coxiella burnetii expresses a sterol-modifying protein designated Stmp1 that is critical for its intracellular survival. Stmp1 reduces cholesterol accumulation in the Coxiella-containing vacuole and dampens the production of 25-hydroxycholesterol in host cells, thereby preventing excessive vacuole acidification and lysosomal fusion. This regulation of host cholesterol homeostasis is essential for establishing a mature vacuolar niche that supports bacterial replication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer cells, a micropeptide also named short transmembrane protein 1 (STMP1) has been identified as a potent promoter of mitochondrial dynamics and metastatic behavior. Localizing to the inner mitochondrial membrane, STMP1 enhances the activation of dynamin-related protein 1 (DRP1), leading to increased mitochondrial fission and redistribution of mitochondria to the leading edge, which in turn promotes lamellipodia formation and tumor cell migration. Additionally, STMP1 interacts with myosin heavy chain 9 (MYH9) to facilitate these effects, underscoring its role as a novel unit within the mitochondrial fission machinery that drives metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Benjamin H Mullin, Kun Zhu, Suzanne J Brown, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget's disease of bone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-37609-0"}], "href": "https://doi.org/10.1038/s41598-018-37609-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30705363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30705363"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tatiana M Clemente, Rochelle Ratnayake, Dhritiman Samanta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates Cholesterol in the Intracellular Niche."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mbio.03073-21"}], "href": "https://doi.org/10.1128/mbio.03073-21"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35073737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35073737"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chen Xie, Feng-Yi Wang, Ye Sang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial Micropeptide STMP1 Enhances Mitochondrial Fission to Promote Tumor Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-21-3910"}], "href": "https://doi.org/10.1158/0008-5472.CAN-21-3910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35544764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35544764"}]}]}]}