{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe two studies primarily focus on the role of RCC2 and its downstream mediators in different biological contexts. In the first study, a skin‐targeted deletion of EGFR in mice leads to aberrant hair follicle cycling, where EGFR normally acts to suppress mitotic regulators such as RCC2 and Stathmin 1 to ensure proper catagen entry and cessation of proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the second study, elevated RCC2 levels in esophageal cancer correlate with enhanced cell proliferation and tumorigenesis through stabilization and transcriptional activation of the transcription factor Sox2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, although the query raises STPG3‐AS1 as the subject, neither of the abstracts provides any data or discussion on the function of STPG3‐AS1. Thus, based on the available information in these reports, no functional role for STPG3‐AS1 has been identified.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kyle J Bichsel, Brianna Hammiller, Carol S Trempus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/exd.12921"}], "href": "https://doi.org/10.1111/exd.12921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26661905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26661905"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ali Calderon-Aparicio, Hiroyuki Yamamoto, Humberto De Vitto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-19-1152"}], "href": "https://doi.org/10.1158/1541-7786.MCR-19-1152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32801160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32801160"}]}]}]}