STX2 Gene

HGNC Family	Syntaxins (STX)
Name	syntaxin 2
Description	The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSyntaxin 2 (STX2), also known as epimorphin in its extracellular guise, plays a multifaceted role in cancer progression. In hepatocellular carcinoma, STX2 secreted by activated hepatic stellate cells enhances cancer cell invasion and metastasis by up‐regulating matrix metalloproteinase‐9 through activation of the focal adhesion kinase/extracellular signal‐regulated kinase (FAK/ERK) pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, STX2 functions as an oncogene by interacting with tumor necrosis factor receptor–associated factor 6 (TRAF6) to activate nuclear factor–κB (NF‐κB) signaling and create a positive feedback loop that bolsters both metastasis and cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, in the setting of HIV and HCV co‐infection, increased STX2 (epimorphin) expression in hepatic stellate cells promotes cellular proliferation and invasion, thus contributing to fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in promoting malignancy, STX2/epimorphin is essential for epithelial morphogenesis and differentiation. It directs mammary ductal branching morphogenesis through a unique structural motif that distinguishes it from related syntaxin family members."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In skin, epimorphin mediates keratinocyte differentiation by establishing extracellular signaling gradients, particularly under stress conditions such as UVB irradiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Its dose‐dependent action also modulates epithelial–mesenchymal transitions in ovarian cancer cells, where higher doses promote epithelial differentiation and enhance chemosensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, epimorphin contributes to the repair of fibrotic lung injury by inducing metalloproteinase expression and facilitating extracellular matrix remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIntracellularly, STX2 is a member of the SNARE protein family and plays a critical role in vesicle fusion and exocytosis. Genome‐wide association studies have implicated variations in STX2 in the regulation of von Willebrand factor levels and the risk of arterial thrombosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", while biochemical studies demonstrate that STX2 interacts with Sec1/Munc18 proteins to modulate apical exocytic transport in epithelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Intriguingly, syntaxin‐2 has been detected on the extracellular face of the platelet plasma membrane, where it retains SNARE binding capability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In pancreatic β‐cells, STX2 functions as an inhibitory SNARE by competing with pro‐fusion partners; its dynamic flipping across the plasma membrane regulates insulin secretion and offers a potential target for type‑2 diabetes therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Furthermore, in airway epithelial cells, STX2 associates with Munc13 proteins to control the secretion of MUC5AC, a major mucin component implicated in chronic pulmonary disease"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", with additional genetic studies linking STX2 variations to altered bleeding phenotypes in von Willebrand disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the reproductive system, loss‑of‑function mutations in STX2 result in spermatogenic failure, marked by maturation arrest and the formation of multinucleated spermatocytes, thereby contributing to nonobstructive azoospermia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, preliminary investigations indicate that STX2 may also regulate colorectal cancer cell proliferation, underscoring its multifaceted contribution to oncogenesis and its potential as a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ya-Li Jia, Lei Shi, Jun-Nian Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.24562"}], "href": "https://doi.org/10.1002/hep.24562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22045676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22045676"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yongxia Wang, Honghai Xu, Hongli Jiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0675-x"}], "href": "https://doi.org/10.1038/s41419-018-0675-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29855462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29855462"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lei Shi, Enqiang Qin, Junnian Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0158386"}], "href": "https://doi.org/10.1371/journal.pone.0158386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27362846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27362846"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Connie S Chen, Celeste M Nelson, Davitte Khauv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M805908200"}], "href": "https://doi.org/10.1074/jbc.M805908200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19129200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19129200"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yoji Okugawa, Yohei Hirai "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of extracellular epimorphin leads to impaired epidermal differentiation in HaCaT keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2008.22"}], "href": "https://doi.org/10.1038/jid.2008.22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18273050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18273050"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kok-Hooi Yew, Jennifer Crow, Jeff Hirst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epimorphin-induced MET sensitizes ovarian cancer cells to platinum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0072637"}], "href": "https://doi.org/10.1371/journal.pone.0072637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24039787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24039787"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yasuhiro Terasaki, Yuh Fukuda, Moritaka Suga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epimorphin expression in interstitial pneumonia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1465-9921-6-6"}], "href": "https://doi.org/10.1186/1465-9921-6-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15651999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15651999"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Janine E van Loon, Frank W G Leebeek, Jaap W Deckers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of genetic variations in syntaxin-binding protein-5 and syntaxin-2 on von Willebrand factor concentration and cardiovascular risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Cardiovasc Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCGENETICS.110.957407"}], "href": "https://doi.org/10.1161/CIRCGENETICS.110.957407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21156930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21156930"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Maria Kauppi, Gerd Wohlfahrt, Vesa M Olkkonen "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208315200"}], "href": "https://doi.org/10.1074/jbc.M208315200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12198139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12198139"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Robert Flaumenhaft, Nataliya Rozenvayn, Dian Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2006-11-055772"}], "href": "https://doi.org/10.1182/blood-2006-11-055772"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17485553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17485553"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Fei Kang, Li Xie, Tairan Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-33986-3"}], "href": "https://doi.org/10.1038/s41467-022-33986-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36316316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36316316"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rui Xu, Jia Zhou, Xiang-Dong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Munc13‑4 mediates human neutrophil elastase‑induced airway mucin5AC hypersecretion by interacting with syntaxin2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9015"}], "href": "https://doi.org/10.3892/mmr.2018.9015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29767240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29767240"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Janine E van Loon, Yvonne V Sanders, Eva M de Wee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of genetic variation in STXBP5 and STX2 on von Willebrand factor and bleeding phenotype in type 1 von Willebrand disease patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0040624"}], "href": "https://doi.org/10.1371/journal.pone.0040624"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22792389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22792389"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shigeru Nakamura, Yoshitomo Kobori, Yoshihiko Ueda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STX2 is a causative gene for nonobstructive azoospermia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.23423"}], "href": "https://doi.org/10.1002/humu.23423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29570232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29570232"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yong-Xia Wang, Yong-Zhen Li, Hui-Fang Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STX2 drives colorectal cancer proliferation via upregulation of EXOSC4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.118597"}], "href": "https://doi.org/10.1016/j.lfs.2020.118597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33075373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33075373"}]}]}]}
Synonyms	EPM, STX2B, STX2A, STX2C, EPIM
Proteins	STX2_HUMAN
NCBI Gene ID	2054
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

STX2 has 6,480 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for STX2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

STX2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STX2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of STX2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of STX2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of STX2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of STX2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of STX2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of STX2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STX2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of STX2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of STX2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of STX2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of STX2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with STX2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with STX2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STX2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of STX2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of STX2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of STX2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing STX2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing STX2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing STX2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with STX2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with STX2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing STX2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of STX2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with STX2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with STX2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with STX2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of STX2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by STX2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with STX2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with STX2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with STX2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with STX2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with STX2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with STX2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at STX2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of STX2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of STX2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing STX2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.