{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSTYK1 (also known as NOK) was initially identified as an atypical receptor protein kinase in comprehensive human kinome studies, and its cDNA was later cloned, revealing a broadly expressed gene with diagnostic potential. Elevated STYK1 expression has been found in diverse malignancies such as lung, breast, acute leukemia, non‐small cell lung cancer, and colorectal cancer, suggesting that its aberrant expression may serve as a biomarker for early detection and prognostic evaluation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, STYK1 exerts its oncogenic effects by engaging multiple signaling cascades. In hepatocellular carcinoma and gallbladder carcinoma, STYK1 drives epithelial–mesenchymal transition and metastatic traits via the MEK/ERK and PI3K/AKT pathways, while in nasopharyngeal carcinoma it further promotes glycolysis through PI3K/AKT activation. In non‐small cell lung cancer, overexpressed STYK1 upregulates GPX4 to suppress ferroptosis, and it also reprograms cellular metabolism by enhancing aerobic glycolysis and increasing nuclear histone acetylation through pyruvate dehydrogenase complex translocation. In addition, STYK1 forms complexes with Akt/GSK‑3β and with c‐Src to synergistically activate STAT3, and mutations affecting key residues further modulate its downstream mitogenic signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its core oncogenic signaling, STYK1 contributes to treatment resistance and tumor progression in several cancer types. In castration‐resistant prostate cancer, STYK1 overexpression promotes cell proliferation, while in non‐small cell lung cancer its upregulation reduces levels of the tumor suppressive protein SPINT2. In acute leukemia and ovarian carcinoma, STYK1 functions as a drug resistance factor, and its overexpression in colorectal cancer has been linked to aggressive disease. Moreover, STYK1 modulates the tumor microenvironment by facilitating the genesis and remodeling of blood and lymphatic vessels, and it is implicated in the progression of renal cell carcinoma, intrahepatic cholangiocarcinoma, glioma, and laryngeal squamous cell carcinoma. Notably, animal models of B‑cell chronic lymphocytic leukemia further illustrate the impact of STYK1 on tumorigenesis and immune response modulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G Manning, D B Whyte, R Martinez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The protein kinase complement of the human genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1075762"}], "href": "https://doi.org/10.1126/science.1075762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12471243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12471243"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xin Ye, Chaoneng Ji, Qingshan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isolation and characterization of a human putative receptor protein kinase cDNA STYK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1023/a:1023934017174"}], "href": "https://doi.org/10.1023/a:1023934017174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12841579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12841579"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tomoko Amachika, Daisuke Kobayashi, Ryosuke Moriai, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A novel gene STYK1/NOK is upregulated in estrogen receptor-alpha negative estrogen receptor-beta positive breast cancer cells following estrogen treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-006-9047-1"}], "href": "https://doi.org/10.1007/s11033-006-9047-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17415682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17415682"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Takashi Kondoh, Daisuke Kobayashi, Naoki Tsuji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of serine threonine tyrosine kinase 1/novel oncogene with kinase domain mRNA in patients with acute leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Hematol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exphem.2009.04.010"}], "href": "https://doi.org/10.1016/j.exphem.2009.04.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19409952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19409952"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Peng Chen, Wei-Miao Li, Qiang Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathologic features and prognostic implications of NOK/STYK1 protein expression in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-14-402"}], "href": "https://doi.org/10.1186/1471-2407-14-402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24894011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24894011"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Liang Hu, Hai-Yang Chen, Jian Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-015-1285-y"}], "href": "https://doi.org/10.1186/s12885-015-1285-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25884558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25884558"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zhaowen Wang, Lei Qu, Biao Deng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.09.032"}], "href": "https://doi.org/10.1016/j.bbrc.2019.09.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31542233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31542233"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wei-Ye Shi, Xiao Yang, Bo Huang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2012.09.011"}], "href": "https://doi.org/10.1016/j.febslet.2012.09.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23010592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23010592"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yinyin Wang, Sihan Liu, Guancheng Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2020.109762"}], "href": "https://doi.org/10.1016/j.cellsig.2020.109762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32871210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32871210"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sheng-Qi Hou, Li Liu "}, {"type": "b", "children": [{"type": "t", "text": "NOK mediated mitogenic signaling is altered by P203L and V395I mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Landmark Ed) (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2741/4366"}], "href": "https://doi.org/10.2741/4366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25961552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25961552"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Suyoun Chung, Kenji Tamura, Mutsuo Furihata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2009.01277.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2009.01277.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19664042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19664042"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zhiqiang Ma, Dong Liu, Weimiao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1659-1"}], "href": "https://doi.org/10.1038/s41419-019-1659-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31164631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31164631"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shinya Nirasawa, Daisuke Kobayashi, Takashi Kondoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Significance of serine threonine tyrosine kinase 1 as a drug resistance factor and therapeutic predictor in acute leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2014.2633"}], "href": "https://doi.org/10.3892/ijo.2014.2633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25190507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25190507"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yangyang Shi, Jing Zhang, Mengran Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMAD3 inducing the transcription of  STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28371"}], "href": "https://doi.org/10.1002/jcb.28371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30701575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30701575"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ayla Valinezhad Orang, Reza Safaralizadeh, Mohammad Ali Hosseinpour Feizi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic relevance of overexpressed serine threonine tyrosine kinase/novel oncogene with kinase domain (STYK1/ NOK) mRNA in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2014.15.16.6685"}], "href": "https://doi.org/10.7314/apjcp.2014.15.16.6685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25169509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25169509"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yue Liu, Tianqi Li, Dan Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NOK/STYK1 promotes the genesis and remodeling of blood and lymphatic vessels during tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.07.059"}], "href": "https://doi.org/10.1016/j.bbrc.2016.07.059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27444381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27444381"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Qingfei Cao, Meixue Chen, Zizhi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High Novel Oncogene with Kinase-Domain (NOK) Gene Expression is Associated with the Progression of Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/clin.lab.2015.150626"}], "href": "https://doi.org/10.7754/clin.lab.2015.150626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27012048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27012048"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Mei-Yuan Chen, Hao Zhang, Jian-Xin Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of STYK1 inhibits intrahepatic cholangiocarcinoma development both in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-016-5188-6"}], "href": "https://doi.org/10.1007/s13277-016-5188-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27542675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27542675"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jianping Zhou, Fan Wang, Bingli Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14772424117423"}], "href": "https://doi.org/10.3727/096504016X14772424117423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27983928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27983928"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "X-L Li, Y-Y Huang, T-J Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-β1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202006_21512"}], "href": "https://doi.org/10.26355/eurrev_202006_21512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32572882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32572882"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yin Yang, Li Liu, Haley O Tucker "}, {"type": "b", "children": [{"type": "t", "text": "Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.08.017"}], "href": "https://doi.org/10.1016/j.bbrc.2022.08.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35970044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35970044"}]}]}]}