TAF1 Gene

HGNC Family	Chromatin-modifying enzymes
Name	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
Description	Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTAF1, the largest subunit of the multiprotein complex TFIID, functions as a multifunctional regulator of transcription. It exerts enzymatic activities that include intrinsic protein kinase activity—phosphorylating targets such as p53 at Thr55 to drive cell cycle progression—and histone acetyltransferase (HAT) activity that facilitates transcription of cell cycle regulators like cyclin D1. Structural analyses have revealed that TAF1 contains a conserved central core domain with a winged helix element that directly binds DNA and cooperates with TAF7 to form a compact module; furthermore, its second bromodomain is capable of recognizing specific acyl modifications on lysine residues, thereby potentially interpreting epigenetic signals. TAF1 also acts as a coactivator by interacting with transcriptional regulators such as c‑Jun and the androgen receptor and even participates in RNA polymerase I transcription through binding to UBF, while studies of TFIID biogenesis indicate that TAF1 serves as a critical scaffold during co‑translational assembly."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTAF1 also plays a central role in neural development and disease. In X‑linked dystonia‑parkinsonism (XDP), an SVA‑type retrotransposon insertion in an intron of TAF1 is linked to abnormal splicing and decreased neuron‑specific expression—a defect further modulated by the length of an embedded hexanucleotide repeat. Mutations in TAF1 have been implicated in an X‑linked intellectual disability syndrome, and converging evidence from Huntington’s disease models suggests that compromised TAF1 levels may underlie selective striatal vulnerability. In addition, altered local histone acetylation patterns near TAF1 exons have been reported in XDP, reinforcing the notion that precise regulation of TAF1 expression and processing is critical for normal neural function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its essential role in transcription and neural homeostasis, TAF1’s modular architecture and interaction with its partner TAF1‑like proteins have emerged as key factors in oncogenesis. Somatic mutations in TAF1 and TAF1L have been identified in gastrointestinal cancers, suggesting that alterations in its functions—ranging from transcriptional coactivation to regulation of cell cycle gene expression—may contribute to tumorigenesis. These findings underscore the multifaceted nature of TAF1 in integrating epigenetic signals, coordinating pre‑initiation complex assembly, and executing regulated transcriptional responses that are crucial for both normal cellular function and disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "H Kostka, E Kuhlisch, S Schellong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in the TAFI gene and the risk of venous thrombosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14651335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14651335"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Heng-Hong Li, Andrew G Li, Hilary M Sheppard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(04)00123-6"}], "href": "https://doi.org/10.1016/s1097-2765(04"}, {"type": "t", "text": "00123-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15053879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15053879"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Traci L Hilton, Yun Li, Elizabeth L Dunphy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.10.4321-4332.2005"}], "href": "https://doi.org/10.1128/MCB.25.10.4321-4332.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15870300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15870300"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Peyman Tavassoli, Latif A Wafa, Helen Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2009-0229"}], "href": "https://doi.org/10.1210/me.2009-0229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20181722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20181722"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Susan L Kloet, Jennifer L Whiting, Phil Gafken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00416-12"}], "href": "https://doi.org/10.1128/MCB.00416-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22711989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22711989"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yong Wu, Joy C Lin, Landon G Piluso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2013.10.031"}], "href": "https://doi.org/10.1016/j.molcel.2013.10.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24289924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24289924"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Suparna Bhattacharya, Xiaohua Lou, Peter Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1408293111"}], "href": "https://doi.org/10.1073/pnas.1408293111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24927529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24927529"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kensaku Murano, Mitsuru Okuwaki, Fumitaka Momose, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.146787"}], "href": "https://doi.org/10.1242/jcs.146787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24928901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24928901"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hui Wang, Elizabeth C Curran, Thomas R Hinds, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2014.148"}], "href": "https://doi.org/10.1038/cr.2014.148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25412659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25412659"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "E Megan Flynn, Oscar W Huang, Florence Poy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2015.08.004"}], "href": "https://doi.org/10.1016/j.str.2015.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26365797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26365797"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chudong Cai, Xiaojun Xie, Junyi Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of TAF1, SAT1, and ARHGEF9 as DNA methylation biomarkers for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28999"}], "href": "https://doi.org/10.1002/jcp.28999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31283007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31283007"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Andrea Bernardini, Pooja Mukherjee, Elisabeth Scheer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-023-01026-3"}], "href": "https://doi.org/10.1038/s41594-023-01026-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37386215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37386215"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ryuji Kaji, Satoshi Goto, Gen Tamiya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular dissection and anatomical basis of dystonia: X-linked recessive dystonia-parkinsonism (DYT3)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Invest (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2152/jmi.52.280"}], "href": "https://doi.org/10.2152/jmi.52.280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16366515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16366515"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Satoshi Makino, Ryuji Kaji, Satoshi Ando, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/512129"}], "href": "https://doi.org/10.1086/512129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17273961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17273961"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Thilo Herzfeld, Dagmar Nolte, Ulrich Müller "}, {"type": "b", "children": [{"type": "t", "text": "Structural and functional analysis of the human TAF1/DYT3 multiple transcript system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mamm Genome (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00335-007-9063-z"}], "href": "https://doi.org/10.1007/s00335-007-9063-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17952504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17952504"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jason A O'Rawe, Yiyang Wu, Max J Dörfel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2015.11.005"}], "href": "https://doi.org/10.1016/j.ajhg.2015.11.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26637982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26637982"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Naoto Ito, William T Hendriks, Jyotsna Dhakal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Model Mech (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dmm.022590"}], "href": "https://doi.org/10.1242/dmm.022590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26769797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26769797"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "D Cristopher Bragg, Kotchaphorn Mangkalaphiban, Christine A Vaine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TAF1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1712526114"}], "href": "https://doi.org/10.1073/pnas.1712526114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29229810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29229810"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ana Westenberger, Charles Jourdan Reyes, Gerard Saranza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A hexanucleotide repeat modifies expressivity of X-linked dystonia parkinsonism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.25488"}], "href": "https://doi.org/10.1002/ana.25488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30973967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30973967"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ivó H Hernández, Jorge R Cabrera, María Santos-Galindo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenic SREK1 decrease in Huntington's disease lowers TAF1 mimicking X-linked dystonia parkinsonism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awaa150"}], "href": "https://doi.org/10.1093/brain/awaa150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32533168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32533168"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jamal Al Ali, Christine A Vaine, Shivangi Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X-linked Dystonia-Parkinsonism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mov Disord (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mds.28305"}], "href": "https://doi.org/10.1002/mds.28305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32975318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32975318"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Tiziana Petrozziello, Amanda M Dios, Kaly A Mueller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SVA insertion in X-linked Dystonia Parkinsonism alters histone H3 acetylation associated with TAF1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0243655"}], "href": "https://doi.org/10.1371/journal.pone.0243655"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33315879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33315879"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Theresa Lüth, Joshua Laβ, Susen Schaake, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elucidating Hexanucleotide Repeat Number and Methylation within the X-Linked Dystonia-Parkinsonism (XDP)-Related SVA Retrotransposon in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TAF1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " with Nanopore Sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes13010126"}], "href": "https://doi.org/10.3390/genes13010126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35052466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35052466"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Hye Rim Oh, Chang Hyeok An, Nam Jin Yoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12253-016-0107-0"}], "href": "https://doi.org/10.1007/s12253-016-0107-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27571988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27571988"}]}]}]}
Synonyms	BA2R, TAFII-250, TAFII250, XDP, DYT3/TAF1, N-TAF1, TAF2A, P250, TAF(II)250, CCG1, CCGS, MRXS33, DYT3
Proteins	TAF1_HUMAN
NCBI Gene ID	6872
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TAF1 has 8,504 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 128 datasets.

Click the + buttons to view associations for TAF1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TAF1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAF1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAF1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TAF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TAF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TAF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAF1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving TAF1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TAF1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TAF1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TAF1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TAF1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TAF1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TAF1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with TAF1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TAF1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TAF1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAF1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TAF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TAF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TAF1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TAF1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TAF1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TAF1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TAF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TAF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TAF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TAF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TAF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TAF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TAF1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TAF1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TAF1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TAF1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TAF1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TAF1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TAF1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TAF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TAF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TAF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TAF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.