{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query requested information on TAF11L2, none of the provided abstracts mention or address TAF11L2. Instead, they focus on SLC4A10 (also known as NCBE or NBCn2), a Na⁺‐dependent, electroneutral bicarbonate transporter that plays a central role in neuronal pH regulation and cerebrospinal fluid (CSF) secretion. In neurons, SLC4A10 contributes to the uptake of HCO₃⁻ in exchange for Cl⁻ under a sodium gradient, thereby regulating intracellular pH and modulating synaptic excitability. In the choroid plexus epithelium, its basolateral localization supports the vectorial transport of Na⁺, which is critical for CSF production, and its disruption has been linked to collapsed brain ventricles and protective effects against induced seizures."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, the studies demonstrate that SLC4A10 mediates Na⁺‐dependent HCO₃⁻ uptake with a distinctive stoichiometry that relies on Cl⁻ as the counterion, and that its transport activity is sensitive to inhibitors such as DIDS. Detailed mutagenesis and electrophysiological investigations reveal that key charged amino acids are required for proper function. In addition, alternative splicing produces multiple SLC4A10 variants with distinct N- and C-termini that confer tissue-specific expression patterns; variants predominating in the brain differ from those found in epithelial tissues such as the kidney or small intestine. Compensatory molecular adaptations following genetic disruption of SLC4A10—including altered expression and membrane targeting of related transporters like NHE1, Na⁺/K⁺-ATPase, and NBCe1—underscore its pivotal role in maintaining ion and pH homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, genetic disruption or knockout of SLC4A10 in animal models has provided significant insights into its physiological importance. Loss of SLC4A10 leads to marked reductions of CSF secretion, altered properties of inhibitory synaptic transmission (with reduced GABA release), and even perturbed sensory functions such as vision and hearing. Investigations extend these findings to reveal that SLC4A10 (along with related SLC4 family members) may also support K⁺ transport under certain conditions, with recent molecular dynamics data suggesting that conserved residues coordinate multiple monovalent cations. Collectively, these observations underscore the multifaceted role of SLC4A10 in central nervous system development, neuronal excitability, and organ homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J Praetorius, L N Nejsum, S Nielsen "}, {"type": "b", "children": [{"type": "t", "text": "A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00240.2003"}], "href": "https://doi.org/10.1152/ajpcell.00240.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14592810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14592810"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "C A Hübner, M Hentschke, S Jacobs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the sodium-driven chloride bicarbonate exchanger NCBE during prenatal mouse development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Expr Patterns (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.modgep.2004.08.002"}], "href": "https://doi.org/10.1016/j.modgep.2004.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15567717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15567717"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Li-Ming Chen, Inyeong Choi, Gabriel G Haddad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Regul Integr Comp Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpregu.00497.2007"}], "href": "https://doi.org/10.1152/ajpregu.00497.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17928512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17928512"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "L-M Chen, M L Kelly, J D Rojas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Use of a new polyclonal antibody to study the distribution and glycosylation of the sodium-coupled bicarbonate transporter NCBE in rodent brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2007.10.015"}], "href": "https://doi.org/10.1016/j.neuroscience.2007.10.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18061361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18061361"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stefan Jacobs, Eva Ruusuvuori, Sampsa T Sipilä, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0705487105"}], "href": "https://doi.org/10.1073/pnas.0705487105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18165320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18165320"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Helle Hasager Damkier, Vikram Prasad, Christian Andreas Hübner, et al. 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