{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query mentions TAF11L9, none of the provided abstracts address this gene. Instead, these studies collectively illuminate the diverse roles of semaphorin signaling—particularly through Semaphorin 4C (Sema4C) and its receptor Plexin‐B2—in orchestrating fundamental developmental and homeostatic processes. In the nervous system, Sema4C and related ligands modulate neural tube closure, cerebellar granule cell migration, and synaptic remodeling that underlie memory formation and neurogenesis, thereby contributing to the establishment and plasticity of neural circuits."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond the nervous system, Sema4C–Plexin‐B2 signaling exerts critical influence in nonneuronal tissues. Expression of Plexin‐B2 in specialized endothelial and endocrine cells indicates potential roles in vascular function and hormone regulation, while in the developing kidney this pathway is essential for proper ureteric branching via modulation of growth factor signaling. Moreover, the upregulation of Sema4C during muscle cell differentiation and repair underscores its importance in myogenic terminal differentiation through p38 MAPK activation, and its involvement in ovarian steroidogenesis appears mediated by actin cytoskeletal dynamics via RHOA/ROCK1 signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the immune context, Sema4C plays a pivotal role in regulating B cell function during allergic responses. Deficiency of Sema4C in B cells disrupts cytokine production—diminishing IL-10 while increasing IL-4 output—which exacerbates airway inflammation and highlights the molecule’s importance in maintaining immune homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Viola Maier, Christine Jolicoeur, Helen Rayburn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2010.11.005"}], "href": "https://doi.org/10.1016/j.mcn.2010.11.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21122816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21122816"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hu Yan, Longyan Wu, Changming Shih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.04.022"}], "href": "https://doi.org/10.1016/j.celrep.2017.04.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28467912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28467912"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Manuela Simonetti, Eszter Paldy, Christian Njoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41380-019-0491-4"}], "href": "https://doi.org/10.1038/s41380-019-0491-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31444474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31444474"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Haitao Wu, Jundie Fan, Lingling Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4C expression in neural stem/progenitor cells and in adult neurogenesis induced by cerebral ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-009-9177-8"}], "href": "https://doi.org/10.1007/s12031-009-9177-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19189244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19189244"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Matthias Zielonka, Jingjing Xia, Roland H Friedel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2010.05.007"}], "href": "https://doi.org/10.1016/j.yexcr.2010.05.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20478304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20478304"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Haitao Wu, Xuan Wang, Shuhong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2007.03.002"}], "href": "https://doi.org/10.1016/j.ejcb.2007.03.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17498836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17498836"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nina Perälä, Madis Jakobson, Roxana Ola, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Differentiation (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.diff.2010.10.001"}], "href": "https://doi.org/10.1016/j.diff.2010.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21035938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21035938"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ji-Ae Ko, Toshikazu Gondo, Shinobu Inagaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement of the transmembrane semaphorin Sema4C for myogenic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2005.03.022"}], "href": "https://doi.org/10.1016/j.febslet.2005.03.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15811348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15811348"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dan Chen, Chuqing Wu, Simin Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4C regulates ovarian steroidogenesis through RHOA/ROCK1-mediated actin cytoskeleton rearrangement."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gaad010"}], "href": "https://doi.org/10.1093/molehr/gaad010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36892447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36892447"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Di Xue, Gabriel N Kaufman, Marieme Dembele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1600831"}], "href": "https://doi.org/10.4049/jimmunol.1600831"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27881703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27881703"}]}]}]}