TAF4B Gene

Name	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
Description	TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTAF4b is a subunit of the multisubunit transcription factor TFIID that plays a central role in RNA polymerase II–mediated transcription by contributing to core promoter recognition. Biochemical and structural analyses have demonstrated that TAF4b, in conjunction with its partner TAF12, harbors intrinsic DNA‐binding activity within regions adjacent to its histone fold domain. These studies reveal that interactions mediated by the histone fold domains not only enhance DNA binding but also alter TFIID conformation, thereby fine‐tuning promoter specificity during transcription initiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its general role in transcription, TAF4b functions in a tissue‐specific manner. In the gonads, TAF4b is enriched and is essential for proper ovarian development and early oogenesis by occupying the promoters of key meiosis and oocyte-specifying genes. Its expression is further induced by upstream regulators such as MYC, and it can interact with activators like c-Jun, thereby modulating promoters that control processes including epithelial-to-mesenchymal transition in certain cancer cells. These findings underscore a dual role for TAF4b in both developmental gene regulation and in modifying transcriptional programs relevant to oncogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have further implicated TAF4b in reproductive health. Investigations in families affected by non-obstructive azoospermia and in women with premature ovarian failure, along with high-throughput sequencing approaches, have identified single nucleotide variants in the TAF4B gene that are positively correlated with these infertility phenotypes. These association studies suggest that mutations in TAF4B may disrupt its normal function in transcription and promoter recognition, thereby contributing to gametogenic failure."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hanshuang Shao, Merav Revach, Sandra Moshonov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Core promoter binding by histone-like TAF complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.1.206-219.2005"}], "href": "https://doi.org/10.1128/MCB.25.1.206-219.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15601843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15601843"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei-Li Liu, Robert A Coleman, Patricia Grob, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural changes in TAF4b-TFIID correlate with promoter selectivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.11.003"}], "href": "https://doi.org/10.1016/j.molcel.2007.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18206971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18206971"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kfir Gazit, Sandra Moshonov, Rofa Elfakess, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.011486"}], "href": "https://doi.org/10.1074/jbc.M109.011486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19635797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19635797"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kwesi Teye, Kengo Okamoto, Yuji Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19020761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19020761"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Margarita Kalogeropoulou, Angeliki Voulgari, Vassiliki Kostourou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin alpha6 and cancer cell migration properties."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-09-0159"}], "href": "https://doi.org/10.1158/1541-7786.MCR-09-0159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20353996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20353996"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kathryn J Grive, Eric A Gustafson, Kimberly A Seymour, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1006128"}], "href": "https://doi.org/10.1371/journal.pgen.1006128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27341508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27341508"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Erik A H Knauff, Lude Franke, Michael A van Es, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/dep197"}], "href": "https://doi.org/10.1093/humrep/dep197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19508998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19508998"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Özgecan Ayhan, Mahmut Balkan, Ayse Guven, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2013-102102"}], "href": "https://doi.org/10.1136/jmedgenet-2013-102102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24431330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24431330"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiao Yang, Hao Zhang, Yuting Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association Study Between MTRR, TAF4B, PIWIL1 Variants and Non-Obstructive Azoospermia in Northeast Chinese Han Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/Clin.Lab.2018.180525"}], "href": "https://doi.org/10.7754/Clin.Lab.2018.180525"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30336530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30336530"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiangyin Liu, Qi Xi, Leilei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted Next-Generation Sequencing Identifies Novel Sequence Variations of Genes Associated with Nonobstructive Azoospermia in the Han Population of Northeast China."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.915375"}], "href": "https://doi.org/10.12659/MSM.915375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31377750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31377750"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Qi Xi, Hao Zhang, Xinyue Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of TATA-box binding protein associated factor 4b gene mutations in a Chinese population with nonobstructive azoospermia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000020561"}], "href": "https://doi.org/10.1097/MD.0000000000020561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32502024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32502024"}]}]}]}
Synonyms	SPGF13, TAFII105, TAF2C2
Proteins	TAF4B_HUMAN
NCBI Gene ID	6875
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TAF4B has 6,083 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for TAF4B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TAF4B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAF4B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAF4B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TAF4B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TAF4B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAF4B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TAF4B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TAF4B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TAF4B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TAF4B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TAF4B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TAF4B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TAF4B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAF4B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TAF4B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TAF4B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TAF4B gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TAF4B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TAF4B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TAF4B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TAF4B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TAF4B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TAF4B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TAF4B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TAF4B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TAF4B protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TAF4B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TAF4B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with TAF4B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TAF4B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TAF4B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TAF4B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TAF4B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TAF4B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TAF4B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TAF4B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TAF4B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAF4B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TAF4B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TAF4B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with TAF4B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.