TAF7 Gene

Name	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Description	The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTAF7 is a critical regulatory component of the basal transcription machinery that functions primarily as part of the TFIID complex. In its canonical role, TAF7 associates with TAF1 and serves to inhibit TAF1’s histone acetyltransferase activity until the preinitiation complex is fully assembled. Moreover, TAF7 modulates early transcription events by engaging in cross‐talk with RNA polymerase II C-terminal domain kinases (e.g. CDK7, CDK9, and BRD4), whereby kinase‐mediated phosphorylation events on TAF7 further dictate its inhibitory potency and ensure that transcription initiation proceeds only after proper complex formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role during initiation, TAF7 is pivotal in regulating the transition from initiation to productive elongation. It acts as a molecular switch that is eventually exchanged for elongation factors—an event coordinated by its interactions with transcriptional coactivators such as CIITA and Mediator subunits like MED26. Furthermore, TAF7 participates in stress-induced transcriptional programs; for example, its inducible expression during heat shock is essential for sustained activation of heat shock protein genes, with its modified forms associating with gene bodies to promote efficient elongation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central functions in general transcription, TAF7 acts as a versatile co-regulator in various biological contexts. It directly interacts with transcription factors such as c-Jun to enhance AP-1–mediated transactivation, and its expression level influences pathways controlling polyamine transport, thereby affecting cell proliferation and programmed cell death. TAF7 is also implicated in oncogenic processes—for instance, methylation-dependent modifications of TAF7 modulate the transcription of cell cycle regulators (e.g. cyclin A2) in certain cancers—and genetic variations in TAF7 have been associated with disorders of spermatogenesis. Structural studies further reveal that TAF7 is essential for solubilizing and stabilizing TAF1, underscoring its significance in the assembly and function of TFIID."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anne Gegonne, Jocelyn D Weissman, Meisheng Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF7: a possible transcription initiation check-point regulator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0510031103"}], "href": "https://doi.org/10.1073/pnas.0510031103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16407123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16407123"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anne Gegonne, Jocelyn D Weissman, Hanxin Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0801637105"}], "href": "https://doi.org/10.1073/pnas.0801637105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18391197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18391197"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Susan L Kloet, Jennifer L Whiting, Phil Gafken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00416-12"}], "href": "https://doi.org/10.1128/MCB.00416-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22711989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22711989"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ballachanda N Devaiah, Dinah S Singer "}, {"type": "b", "children": [{"type": "t", "text": "Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.412015"}], "href": "https://doi.org/10.1074/jbc.M112.412015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23027873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23027873"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Suparna Bhattacharya, Xiaohua Lou, Peter Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1408293111"}], "href": "https://doi.org/10.1073/pnas.1408293111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24927529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24927529"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ballachanda N Devaiah, Hanxin Lu, Anne Gegonne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel functions for TAF7, a regulator of TAF1-independent transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.173864"}], "href": "https://doi.org/10.1074/jbc.M110.173864"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20937824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20937824"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hidehisa Takahashi, Ichigaku Takigawa, Masashi Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms6941"}], "href": "https://doi.org/10.1038/ncomms6941"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25575120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25575120"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zoé Lens, François-Xavier Cantrelle, Riccardo Peruzzini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solution Structure of the N-Terminal Domain of Mediator Subunit MED26 and Molecular Characterization of Its Interaction with EAF1 and TAF7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2017.09.001"}], "href": "https://doi.org/10.1016/j.jmb.2017.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28893534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28893534"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mayumi Nagashimada, Takumi Ueda, Yuichiro Ishita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF7 is a heat-inducible unstable protein and is required for sustained expression of heat shock protein genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.14604"}], "href": "https://doi.org/10.1111/febs.14604"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30028080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30028080"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Christine Munz, Eleni Psichari, Dimitris Mandilis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF7 (TAFII55) plays a role in the transcription activation by c-Jun."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M212764200"}], "href": "https://doi.org/10.1074/jbc.M212764200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12676957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12676957"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Junichi Fukuchi, Richard A Hiipakka, John M Kokontis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401078200"}], "href": "https://doi.org/10.1074/jbc.M401078200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15078871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15078871"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hui Wang, Elizabeth C Curran, Thomas R Hinds, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2014.148"}], "href": "https://doi.org/10.1038/cr.2014.148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25412659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25412659"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shuai Hao, Wuguo Tian, Yi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-374c-5p inhibits the development of breast cancer through TATA-box binding protein associated factor 7-mediated transcriptional regulation of DEP domain containing 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28803"}], "href": "https://doi.org/10.1002/jcb.28803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31162714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31162714"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Samudra Pal, Pranab Paladhi, Saurav Dutta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel variations in spermatogenic transcription regulators RFX2 and TAF7 increase risk of azoospermia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Assist Reprod Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10815-021-02352-5"}], "href": "https://doi.org/10.1007/s10815-021-02352-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34762273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34762273"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jinyuan Zhang, Baojun Duan, Fang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETD7 Promotes Cell Proliferation and Migration via Methylation-mediated TAF7 in Clear Cell Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.93201"}], "href": "https://doi.org/10.7150/ijbs.93201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38904013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38904013"}]}]}]}
Synonyms	TAF2F, TAFII55
Proteins	TAF7_HUMAN
NCBI Gene ID	6879
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TAF7 has 6,273 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 116 datasets.

Click the + buttons to view associations for TAF7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TAF7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAF7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TAF7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TAF7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAF7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TAF7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TAF7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TAF7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TAF7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TAF7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TAF7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TAF7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAF7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TAF7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TAF7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TAF7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TAF7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TAF7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing TAF7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TAF7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TAF7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TAF7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TAF7 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TAF7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TAF7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TAF7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TAF7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TAF7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with TAF7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TAF7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TAF7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TAF7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TAF7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAF7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TAF7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TAF7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with TAF7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with TAF7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TAF7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with TAF7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing TAF7 from the GeneSigDB Published Gene Signatures dataset.