| Name | TAFA chemokine like family member 5 |
| Description | This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTAFA5, also known as FAM19A5, is a secreted chemokine‐like protein that functions in vascular remodeling by inhibiting the proliferation and migration of vascular smooth muscle cells and reducing neointima formation in injured arteries, thereby potentially limiting adverse vascular changes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the central nervous system, FAM19A5 is predominantly expressed in the brain and its altered levels have been linked to neurological conditions. For instance, its serum concentrations correlate with cognitive impairment in subjects with vascular dementia and might also be involved in the inflammatory processes underlying cerebral small vessel disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, TAFA5 displays oncogenic properties. It is upregulated in gastric cancer where its overexpression is associated with poor tumor differentiation, advanced tumor stage, and enhanced cell proliferation, migration, and epithelial–mesenchymal transition. Moreover, the FAM19A5/S1PR1 signaling axis has been shown to promote the viability and proliferation of mantle cell lymphoma cells, suggesting that TAFA5 may serve as a potential therapeutic target in malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in vascular and nervous systems as well as cancer, FAM19A5 acts as an adipokine implicated in metabolic regulation. Its levels have been investigated in relation to nonalcoholic fatty liver disease and subclinical atherosclerosis, and fluctuations in its serum concentration have been linked to dyslipidaemia and other metabolic syndrome components."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "You-Bin Lee, Hwan-Jin Hwang, Jung A Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of serum FAM19A5 with metabolic and vascular risk factors in human subjects with or without type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diab Vasc Dis Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1479164119860746"}], "href": "https://doi.org/10.1177/1479164119860746"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31280604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31280604"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Juan Li, Shoulin Li, Yihong Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8895900"}], "href": "https://doi.org/10.1155/2020/8895900"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32831973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32831973"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhongnan Hao, Shaonan Yang, Ruihua Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.13101"}], "href": "https://doi.org/10.7717/peerj.13101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35282278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35282278"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhiqing Hu, Gengming Niu, Jun Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAFA5 promotes proliferation and migration in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10724"}], "href": "https://doi.org/10.3892/mmr.2019.10724"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31702029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31702029"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yanfang Wang, Zhenhao Zhang, Wei Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM19A5/S1PR1 signaling pathway regulates the viability and proliferation of mantle cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Recept Signal Transduct Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10799893.2021.1895220"}], "href": "https://doi.org/10.1080/10799893.2021.1895220"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33685344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33685344"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fatemeh Ali Yari, Parisa Shabani, Sara Karami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Endocr Disord (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12902-021-00820-8"}], "href": "https://doi.org/10.1186/s12902-021-00820-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34344333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34344333"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "A Wesolek, K Skoracka, K Skrypnik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assessment of progranulin and FAM19A5 protein blood levels in patients with metabolic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol Pharmacol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26402/jpp.2022.1.13"}], "href": "https://doi.org/10.26402/jpp.2022.1.13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35793765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35793765"}]}]}]}
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| NCBI Gene ID | 25817 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TAFA5 has 1,392 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 24 datasets.
Click the + buttons to view associations for TAFA5 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TAFA5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of TAFA5 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing TAFA5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TAFA5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with TAFA5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TAFA5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving TAFA5 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by TAFA5 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of TAFA5 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TAFA5 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with TAFA5 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with TAFA5 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TAFA5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of TAFA5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of TAFA5 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of TAFA5 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TAFA5 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TAFA5 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TAFA5 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of TAFA5 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of TAFA5 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TAFA5 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TAFA5 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TAFA5 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
