{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe long non‐coding RNA TARID functions as an epigenetic regulator by binding directly to the promoter region of the tumor suppressor gene TCF21, where it recruits key demethylation factors such as GADD45A. This interaction facilitates the active removal of DNA methylation marks—via the engagement of downstream enzymes like thymine-DNA glycosylase and ten-eleven translocation proteins—thereby switching TCF21 expression on. This molecular mechanism was delineated and validated through studies demonstrating a role for TARID as a genomic “address label” for targeted promoter demethylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \n \nThe etiopathogenesis of disorders such as preeclampsia is complex, with insufficient trophoblast invasion and defective uterine spiral artery remodeling being key features; however, the precise mechanisms remain unclear. Though not directly examined in this context, the paradigm of TARID-mediated promoter demethylation offers a potential model for investigating epigenetic regulation in placental development and the progression of preeclampsia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \n \nIn addition to its established role in activating TCF21 in tumorigenesis, TARID has been implicated in the modulation of coronary artery disease risk. While the mechanisms linking TARID and its genetic variants to CAD remain to be fully elucidated, current evidence underscores its broader significance in disease-related epigenetic reprogramming through transcriptional control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Khelifa Arab, Yoon Jung Park, Anders M Lindroth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2014.06.031"}], "href": "https://doi.org/10.1016/j.molcel.2014.06.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25087872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25087872"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lingyun Liao, Min Liu, Yijie Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-022-01036-8"}], "href": "https://doi.org/10.1186/s12958-022-01036-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36401313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36401313"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zheng Cheng, Yonghong Zhang, Yang Zhuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TARID induces cell proliferation through cell cycle pathway associated with coronary artery disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-022-07304-5"}], "href": "https://doi.org/10.1007/s11033-022-07304-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35304681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35304681"}]}]}]}