TAS2R30 Gene

HGNC Family G protein-coupled receptors
Name taste receptor, type 2, member 30
Description Enables bitter taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided here illuminates critical regulators of cell cycle progression and cytoskeletal dynamics. Several of these abstracts focus on proteins such as Hec1 (Ndc80) and its role in the regulation of kinetochore–microtubule interactions, the activation of cyclin‐dependent kinases during M phase entry, and the maintenance of spindle assembly and chromosomal integrity in both mitosis and meiosis. In addition, key insights are offered into the functions of microtubule‐severing enzymes (e.g., members of the katanin family) that govern microtubule reorganization, a process essential for successful cell division and spermatogenesis. Collectively, these findings underscore the importance of precise regulation of spindle dynamics, kinetochore function, and cytoskeletal remodeling in ensuring genomic stability and normal physiological processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, none of these abstracts address the function or potential regulatory mechanisms of TAS2R30. TAS2R30 is a member of the bitter taste receptor family typically associated with chemosensory perception, and its roles—whether confined to gustatory signaling or extended to extra‐oral activities—are not explored within the context of these studies. This absence of data leaves open questions regarding any possible involvement of TAS2R30 in cell cycle regulation, cytoskeletal organization, or other cellular processes that are central to the work described in these publications. Future research will be required to determine if TAS2R30 may have unanticipated functions beyond taste perception that intersect with the molecular pathways highlighted in these abstracts.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anja M Faisst, Gonzalo Alvarez-Bolado, Dieter Treichel, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nt mutation causing laterality defects associated with deletion of rotatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mamm Genome (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00335-007-9023-7"}], "href": "https://doi.org/10.1007/s00335-007-9023-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17551791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17551791"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elena Diaz-Rodríguez, Rocio Sotillo, Juan-Manuel Schvartzman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0803504105"}], "href": "https://doi.org/10.1073/pnas.0803504105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18940925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18940925"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shao-Chen Sun, Ding-Xiao Zhang, Seung-Eun Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ndc80 regulates meiotic spindle organization, chromosome alignment, and cell cycle progression in mouse oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microsc Microanal (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1017/S1431927611000274"}], "href": "https://doi.org/10.1017/S1431927611000274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21600073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21600073"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lee B Smith, Laura Milne, Nancy Nelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002697"}], "href": "https://doi.org/10.1371/journal.pgen.1002697"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22654668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22654668"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Liming Gui, Hayden Homer "}, {"type": "b", "children": [{"type": "t", "text": "Hec1-dependent cyclin B2 stabilization regulates the G2-M transition and early prometaphase in mouse oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2013.02.008"}], "href": "https://doi.org/10.1016/j.devcel.2013.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23541922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23541922"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nicole J Camlin, Eileen A McLaughlin, Janet E Holt "}, {"type": "b", "children": [{"type": "t", "text": "Kif4 Is Essential for Mouse Oocyte Meiosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0170650"}], "href": "https://doi.org/10.1371/journal.pone.0170650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28125646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28125646"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yukimasa Makita, Shumpei Murata, Yoshiki Katou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anti-tumor activity of KNTC2 siRNA in orthotopic tumor model mice of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.08.088"}], "href": "https://doi.org/10.1016/j.bbrc.2017.08.088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28843857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28843857"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Eiko Hatakeyama, Kensuke Hayashi "}, {"type": "b", "children": [{"type": "t", "text": "KATNAL1 is a more active and stable isoform of katanin, and is expressed dominantly in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.048"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30448058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30448058"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lei-Lei Gao, Fei Xu, Zhen Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microtubule‑severing protein Katanin p60 ATPase‑containing subunit A‑like 1 is involved in pole‑based spindle organization during mouse oocyte meiosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10605"}], "href": "https://doi.org/10.3892/mmr.2019.10605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31485656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31485656"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shuhei Yoshida, Sui Nishiyama, Lisa Lister, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-16488-y"}], "href": "https://doi.org/10.1038/s41467-020-16488-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32461611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32461611"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kai Kang, Nana Li, Yang Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/8950130"}], "href": "https://doi.org/10.1155/2022/8950130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35979014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35979014"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jessica E M Dunleavy, Maddison Graffeo, Kathryn Wozniak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in mammalian meiosis and spermiogenesis to achieve male fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.201956"}], "href": "https://doi.org/10.1242/dev.201956"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37882691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37882691"}]}]}]}
Synonyms T2R30, TAS2R47, T2R47
Proteins T2R30_HUMAN
NCBI Gene ID 259293
API
Download Associations
Predicted Functions View TAS2R30's ARCHS4 Predicted Functions.
Co-expressed Genes View TAS2R30's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View TAS2R30's ARCHS4 Predicted Functions.

Functional Associations

TAS2R30 has 1,540 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 43 datasets.

Click the + buttons to view associations for TAS2R30 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of TAS2R30 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of TAS2R30 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of TAS2R30 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of TAS2R30 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of TAS2R30 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of TAS2R30 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing TAS2R30 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with TAS2R30 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with TAS2R30 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of TAS2R30 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with TAS2R30 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by TAS2R30 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with TAS2R30 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with TAS2R30 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at TAS2R30 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAS2R30 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of TAS2R30 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GO Biological Process Annotations 2015 biological processes involving TAS2R30 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving TAS2R30 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving TAS2R30 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing TAS2R30 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by TAS2R30 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by TAS2R30 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by TAS2R30 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of TAS2R30 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of TAS2R30 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for TAS2R30 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of TAS2R30 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of TAS2R30 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEGG Pathways 2026 pathways involving TAS2R30 protein from the KEGG Pathways 2026 dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of TAS2R30 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of TAS2R30 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
NURSA Protein Complexes protein complexs containing TAS2R30 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
Reactome Pathways 2014 pathways involving TAS2R30 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving TAS2R30 protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at TAS2R30 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of TAS2R30 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of TAS2R30 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of TAS2R30 gene from the RummaGEO Gene Perturbation Signatures dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of TAS2R30 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of TAS2R30 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with TAS2R30 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with TAS2R30 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.