{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of abstracts provided offers a broad view of the neuroendocrine mechanisms regulating energy balance, feeding behavior, and metabolic homeostasis. These studies detail how gut‐derived hormones such as ghrelin—as well as orexigenic neuropeptides including neuropeptide Y (NPY) and agouti‐related protein (AgRP)—modulate neuronal activity, mitochondrial function, and systemic metabolic responses through diverse intracellular pathways, receptor interactions, and neural circuitry. For example, several studies describe ghrelin’s activation of mitochondrial respiration and its dependence on UCP2 to stimulate feeding (e.g."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and the essential roles of NPY and AgRP in mediating orexigenic responses (e.g.."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Additional works in the set probe the impact of these neuropeptides on stress‐induced metabolic adaptations, neurogenesis, sympathetic outflow, and even bone homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, none of the abstracts reference or investigate TAS2R41. TAS2R41 belongs to the type 2 taste receptor family—a group classically implicated in bitter taste perception—and while it has been proposed to have modulatory roles beyond the gustatory system in other contexts, the current corpus of literature does not report any data on its expression, signaling functions, or influence on metabolic and neuroendocrine pathways. Thus, with respect to the provided studies, there is no available evidence to ascribe a functional role to TAS2R41.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the abstracts illuminate key mechanisms by which ghrelin, NPY, AgRP, and related intracellular systems integrate peripheral and central signals to control feeding, energy expenditure, stress responses, and even bone and immune functions"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_fs", "start_ref": "12", "end_ref": "18"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "19"}, {"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "21", "end_ref": "26"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_fs", "start_ref": "27", "end_ref": "31"}]}, {"type": "t", "text": "—there is no discussion of TAS2R41, leaving its potential roles in physiology to be explored in future studies.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zane B Andrews, Zhong-Wu Liu, Nicholas Walllingford, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2003-1596"}], "href": "https://doi.org/10.1210/en.2003-1596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14962995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14962995"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kanji A Takahashi, Roger D Cone "}, {"type": "b", "children": [{"type": "t", "text": "Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2004-1397"}], "href": "https://doi.org/10.1210/en.2004-1397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15591135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15591135"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lydia E Kuo, Joanna B Kitlinska, Jason U Tilan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1611"}], "href": "https://doi.org/10.1038/nm1611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17603492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17603492"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yan-Chuan Shi, Jackie Lau, Zhou Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2013.01.006"}], "href": "https://doi.org/10.1016/j.cmet.2013.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23395170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23395170"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "John C Igwe, Xi Jiang, Frane Paic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22294"}], "href": "https://doi.org/10.1002/jcb.22294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19670271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19670271"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "P D Raposinho, D D Pierroz, P Broqua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0303-7207(01)00620-7"}], "href": "https://doi.org/10.1016/s0303-7207(01"}, {"type": "t", "text": "00620-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11738809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11738809"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hongqin Wang, Len H Storlien, Xu-Feng Huang "}, {"type": "b", "children": [{"type": "t", "text": "Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00230.2001"}], "href": "https://doi.org/10.1152/ajpendo.00230.2001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12006366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12006366"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Su Qian, Howard Chen, Drew Weingarth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.14.5027-5035.2002"}], "href": "https://doi.org/10.1128/MCB.22.14.5027-5035.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12077332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12077332"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "A Thorsell, M Heilig "}, {"type": "b", "children": [{"type": "t", "text": "Diverse functions of neuropeptide Y revealed using genetically modified animals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropeptides (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1054/npep.2002.0897"}], "href": "https://doi.org/10.1054/npep.2002.0897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12359508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12359508"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shozo Jinno, Toshio Kosaka "}, {"type": "b", "children": [{"type": "t", "text": "Patterns of expression of neuropeptides in GABAergic nonprincipal neurons in the mouse hippocampus: Quantitative analysis with optical disector."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Comp Neurol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cne.10700"}], "href": "https://doi.org/10.1002/cne.10700"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12746872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12746872"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Gavin A Bewick, James V Gardiner, Waljit S Dhillo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.04-3434fje"}], "href": "https://doi.org/10.1096/fj.04-3434fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16099943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16099943"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Blanca Ramos, David Baglietto-Vargas, Juan Carlos del Rio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2005.09.022"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2005.09.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16271420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16271420"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shu Lin, Dana Boey, Nicola Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropeptides (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.npep.2005.11.006"}], "href": "https://doi.org/10.1016/j.npep.2005.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16439015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16439015"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mallappa Anitha, Bindu Chandrasekharan, Joana R Salgado, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glial-derived neurotrophic factor modulates enteric neuronal survival and proliferation through neuropeptide Y."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2006.07.019"}], "href": "https://doi.org/10.1053/j.gastro.2006.07.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17030186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17030186"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xavier Fioramonti, Sylvain Contié, Zhentao Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db06-0567"}], "href": "https://doi.org/10.2337/db06-0567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17261674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17261674"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Owain W Howell, Sharmalene Silva, Helen E Scharfman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2006.12.014"}], "href": "https://doi.org/10.1016/j.nbd.2006.12.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17317195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17317195"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Katsuhiko Asanuma, Kirk Nicholas Campbell, Kwanghee Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0700917104"}], "href": "https://doi.org/10.1073/pnas.0700917104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17537921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17537921"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Suvi T Ruohonen, Ullamari Pesonen, Niko Moritz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transgenic mice overexpressing neuropeptide Y in noradrenergic neurons: a novel model of increased adiposity and impaired glucose tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db07-0722"}], "href": "https://doi.org/10.2337/db07-0722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18276767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18276767"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Tim Karl, Liesl Duffy, Herbert Herzog "}, {"type": "b", "children": [{"type": "t", "text": "Behavioural profile of a new mouse model for NPY deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1460-9568.2008.06306.x"}], "href": "https://doi.org/10.1111/j.1460-9568.2008.06306.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18616565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18616565"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Bindu Chandrasekharan, Vanitha Bala, Vasantha L Kolachala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0003304"}], "href": "https://doi.org/10.1371/journal.pone.0003304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18836554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18836554"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Melissa J S Chee, Martin G Myers, Christopher J Price, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4031-09.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.4031-09.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20203197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20203197"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Raquel Ferreira, Sara Xapelli, Tiago Santos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.164020"}], "href": "https://doi.org/10.1074/jbc.M110.164020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20959451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20959451"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Brian Solway, Soma C Bose, Gregory Corder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tonic inhibition of chronic pain by neuropeptide Y."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1017719108"}], "href": "https://doi.org/10.1073/pnas.1017719108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21482764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21482764"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Kristen R Vella, Preeti Ramadoss, Francis S Lam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2011.10.009"}], "href": "https://doi.org/10.1016/j.cmet.2011.10.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22100407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22100407"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Tadashi Yoshida, Laura Semprun-Prieto, Richard D Wainford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2011-1764"}], "href": "https://doi.org/10.1210/en.2011-1764"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22234465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22234465"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Scott B Baver, Kevin Hope, Shannon Guyot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4861-12.2014"}], "href": "https://doi.org/10.1523/JNEUROSCI.4861-12.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24741039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24741039"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "José K van den Heuvel, Kara Furman, Myrtille C R Gumbs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2014.06.008"}], "href": "https://doi.org/10.1016/j.biopsych.2014.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25109664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25109664"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Hana Uhlirova, Kıvılcım Kılıç, Peifang Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell type specificity of neurovascular coupling in cerebral cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.14315"}], "href": "https://doi.org/10.7554/eLife.14315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27244241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27244241"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Ming-Dong Zhang, Swapnali Barde, Ting Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1614017113"}], "href": "https://doi.org/10.1073/pnas.1614017113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27791037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27791037"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Linda Engström Ruud, Mafalda M A Pereira, Alain J de Solis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-14291-3"}], "href": "https://doi.org/10.1038/s41467-020-14291-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31974377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31974377"}]}]}]}