| HGNC Family | G protein-coupled receptors |
| Name | taste receptor, type 2, member 42 |
| Description | Predicted to enable G protein-coupled receptor activity and bitter taste receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of bitter taste. Located in membrane. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA thorough review of the provided abstracts reveals no mention or characterization of TAS2R42. Instead, the collection exclusively focuses on the roles of key transcriptional regulators—most notably Blimp-1 (encoded by PRDM1) and its interacting partners such as Bcl6—as well as other factors (e.g., TCF-1, IRF4, XBP1) in controlling cell fate decisions and differentiation in diverse biological contexts. These studies detail how Blimp-1 coordinates the terminal differentiation of B cells into antibody‐secreting plasma cells, modulates T cell effector and memory programs, and even governs aspects of developmental processes in tissues such as germ cells, skin, and the neural retina. They also describe antagonistic interactions (for example, between Blimp-1 and Bcl6) that balance immune cell activation, migration, and the establishment of proper gene expression networks, thereby ensuring immune homeostasis and effective host responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional abstracts extend these findings by demonstrating how Blimp-1 and its regulatory network influence CD8⁺ T cell terminal differentiation and memory potential, control osteoclastogenesis for bone homeostasis, direct retinal cell fate decisions, and even impact the development of certain lymphomas—thereby reiterating a central theme of transcription factor–mediated modulation of cell differentiation. Notably, despite the breadth of these insights into gene regulatory mechanisms across immune and non-immune cell types, none of the reviewed studies provide any data regarding TAS2R42. This omission underscores that, while the molecular underpinnings of Blimp-1– and Bcl6-mediated processes are well documented, the biological function of TAS2R42 remains unaddressed in this body of work."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kuo-I Lin, Cristina Angelin-Duclos, Tracy C Kuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.13.4771-4780.2002"}], "href": "https://doi.org/10.1128/MCB.22.13.4771-4780.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12052884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12052884"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "David H Chang, Giorgio Cattoretti, Kathryn L Calame "}, {"type": "b", "children": [{"type": "t", "text": "The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mech Dev (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0925-4773(02)00189-2"}], "href": "https://doi.org/10.1016/s0925-4773(02"}, {"type": "t", "text": "00189-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12204275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12204275"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "A L Shaffer, Miriam Shapiro-Shelef, Neal N Iwakoshi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2004.06.010"}], "href": "https://doi.org/10.1016/j.immuni.2004.06.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15345222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15345222"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Axel Kallies, Jhagvaral Hasbold, David M Tarlinton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma cell ontogeny defined by quantitative changes in blimp-1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20040973"}], "href": "https://doi.org/10.1084/jem.20040973"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15492122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15492122"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tracy C Kuo, Kathryn L Calame "}, {"type": "b", "children": [{"type": "t", "text": "B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.173.9.5556"}], "href": "https://doi.org/10.4049/jimmunol.173.9.5556"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15494505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15494505"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yasuhide Ohinata, Bernhard Payer, Dónal O'Carroll, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2009.06.021"}], "href": "https://doi.org/10.1016/j.immuni.2009.06.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19664942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19664942"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Haina Shin, Shawn D Blackburn, Andrew M Intlekofer, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2009.10.008"}], "href": "https://doi.org/10.1016/j.immuni.2009.10.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20064451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20064451"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Joseph A Brzezinski, Deepak A Lamba, Thomas A Reh "}, {"type": "b", "children": [{"type": "t", "text": "Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.043968"}], "href": "https://doi.org/10.1242/dev.043968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20110327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20110327"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yoshiteru Miyauchi, Ken Ninomiya, Hiroya Miyamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20091957"}], "href": "https://doi.org/10.1084/jem.20091957"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20368579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20368579"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jonathan Mandelbaum, Govind Bhagat, Hongyan Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2010.10.030"}], "href": "https://doi.org/10.1016/j.ccr.2010.10.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21156281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21156281"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Dinis Pedro Calado, Baochun Zhang, Lakshmi Srinivasan, et al. 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| Synonyms | T2R42, T2R55, TAS2R55, T2R24 |
| Proteins | T2R42_HUMAN |
| NCBI Gene ID | 353164 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TAS2R42 has 1,339 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 52 datasets.
Click the + buttons to view associations for TAS2R42 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by TAS2R42 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of TAS2R42 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TAS2R42 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TAS2R42 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAS2R42 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of TAS2R42 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of TAS2R42 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of TAS2R42 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing TAS2R42 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing TAS2R42 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing TAS2R42 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TAS2R42 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TAS2R42 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with TAS2R42 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by TAS2R42 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TAS2R42 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with TAS2R42 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TAS2R42 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAS2R42 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of TAS2R42 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with TAS2R42 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TAS2R42 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TAS2R42 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving TAS2R42 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving TAS2R42 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by TAS2R42 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by TAS2R42 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of TAS2R42 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TAS2R42 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with TAS2R42 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of TAS2R42 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of TAS2R42 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by TAS2R42 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TAS2R42 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of TAS2R42 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TAS2R42 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving TAS2R42 protein from the KEGG Pathways dataset. | |
| KEGG Pathways 2026 | pathways involving TAS2R42 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TAS2R42 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of TAS2R42 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain TAS2R42 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by TAS2R42 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TAS2R42 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of TAS2R42 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Reactome Pathways 2014 | pathways involving TAS2R42 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving TAS2R42 protein from the Reactome Pathways 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TAS2R42 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TAS2R42 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TAS2R42 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of TAS2R42 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TAS2R42 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TAS2R42 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
