TAS2R45 Gene

HGNC Family G protein-coupled receptors
Name taste receptor, type 2, member 45
Description Predicted to enable G protein-coupled receptor activity and bitter taste receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of bitter taste. Located in membrane. [provided by Alliance of Genome Resources, Mar 2025]
Synonyms ZG24P, T2R45, GPR59
Proteins T2R45_HUMAN
NCBI Gene ID 259291
API
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Predicted Functions View TAS2R45's ARCHS4 Predicted Functions.
Co-expressed Genes View TAS2R45's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View TAS2R45's ARCHS4 Predicted Functions.

Functional Associations

TAS2R45 has 351 functional associations with biological entities spanning 5 categories (organism, chemical, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.

Click the + buttons to view associations for TAS2R45 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by TAS2R45 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of TAS2R45 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of TAS2R45 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of TAS2R45 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of TAS2R45 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of TAS2R45 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of TAS2R45 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of TAS2R45 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of TAS2R45 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2023 biological processes involving TAS2R45 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving TAS2R45 gene from the curated GO Biological Process Annotations2025 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by TAS2R45 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by TAS2R45 gene from the curated GO Molecular Function Annotations 2025 dataset.
KEGG Pathways pathways involving TAS2R45 protein from the KEGG Pathways dataset.
KEGG Pathways 2026 pathways involving TAS2R45 protein from the KEGG Pathways 2026 dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of TAS2R45 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Reactome Pathways 2014 pathways involving TAS2R45 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving TAS2R45 protein from the Reactome Pathways 2024 dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of TAS2R45 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of TAS2R45 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of TAS2R45 gene from the RummaGEO Gene Perturbation Signatures dataset.