TAX1BP3 Gene

Name	Tax1 (human T-cell leukemia virus type I) binding protein 3
Description	This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTAX1BP3 (also known as TIP‐1 or GIP) is a small, atypical PDZ‐domain protein that plays a multifaceted role in cellular signaling. Early studies showed that TAX1BP3 binds to the C-terminus of beta-catenin via its PDZ domain, thereby negatively regulating Wnt/beta-catenin transcriptional activity and suppressing proliferation and anchorage-independent growth in colorectal cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, a homozygous missense mutation in TAX1BP3 was found to cause a novel autosomal recessive syndrome characterized by dilated cardiomyopathy and septo-optic dysplasia, underscoring its essential role in heart and brain development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in modulating Wnt signaling, TAX1BP3 is implicated in controlling cell motility and morphology. It forms complexes with viral oncoproteins such as HPV16 E6 and appears to coordinate the spatial and temporal activation of Rho GTPases by interacting with guanine nucleotide exchange factors, thereby modulating the RhoA/ROCK pathway and affecting cell adhesion, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " Moreover, studies in glioma models have demonstrated that TAX1BP3 enhances cell motility and contributes to radiation resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTAX1BP3 also functions as a versatile adaptor and regulator of protein-protein interactions. Structural and biochemical analyses have revealed that TAX1BP3 employs a flexible PDZ binding pocket to engage not only C-terminal recognition motifs—as seen with channels like Kir 2.3 where it competes with other scaffolds to regulate membrane targeting—but also noncanonical internal motifs present in signaling molecules."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In addition, TAX1BP3 interacts with a broad array of partners including FAS, BAI2, DTX1, and STAU1, highlighting its role in processes ranging from apoptosis to neural function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mutsumi Kanamori, Peter Sandy, Stefania Marzinotto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M306324200"}], "href": "https://doi.org/10.1074/jbc.M306324200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12874278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12874278"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miaojun Han, Hailun Wang, Hua-Tang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2012.04.123"}], "href": "https://doi.org/10.1016/j.bbrc.2012.04.123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22564736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22564736"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eyal Reinstein, Katia Orvin, Einav Tayeb-Fligelman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22759"}], "href": "https://doi.org/10.1002/humu.22759"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25645515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25645515"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lynne Hampson, Chenggang Li, Anthony William Oliver, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2004)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15492812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15492812"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "A W Oliver, X He, K Borthwick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6606026"}], "href": "https://doi.org/10.1038/sj.bjc.6606026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21139582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21139582"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "H Wang, M Han, W Whetsell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.97"}], "href": "https://doi.org/10.1038/onc.2013.97"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23563176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23563176"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Miaojun Han, Hailun Wang, Hua-Tang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of TIP-1 confers radioresistance of malignant glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0045402"}], "href": "https://doi.org/10.1371/journal.pone.0045402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23028987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23028987"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Christine Alewine, Olav Olsen, James B Wade, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIP-1 has PDZ scaffold antagonist activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e06-02-0129"}], "href": "https://doi.org/10.1091/mbc.e06-02-0129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16855024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16855024"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiaojie Yan, Hao Zhou, Jinxiu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2009.07.060"}], "href": "https://doi.org/10.1016/j.jmb.2009.07.060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19635485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19635485"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Monimoy Banerjee, Chengdong Huang, Javier Marquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Probing the structure and function of human glutaminase-interacting protein: a possible target for drug design."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi800287v"}], "href": "https://doi.org/10.1021/bi800287v"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18690705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18690705"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sevil Zencir, Mohiuddin Ovee, Melanie J Dobson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.07.029"}], "href": "https://doi.org/10.1016/j.bbrc.2011.07.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21787750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21787750"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sevil Zencir, Monimoy Banerjee, Melanie J Dobson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.01.098"}], "href": "https://doi.org/10.1016/j.bbrc.2013.01.098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23395680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23395680"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Monimoy Banerjee, David L Zoetewey, Mohiuddin Ovee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi3008033"}], "href": "https://doi.org/10.1021/bi3008033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22876914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22876914"}]}]}]}
Synonyms	TIP-1, TIP1
Proteins	TX1B3_HUMAN
NCBI Gene ID	30851
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TAX1BP3 has 6,720 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for TAX1BP3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TAX1BP3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAX1BP3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAX1BP3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TAX1BP3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TAX1BP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TAX1BP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TAX1BP3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving TAX1BP3 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TAX1BP3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TAX1BP3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TAX1BP3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TAX1BP3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TAX1BP3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAX1BP3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TAX1BP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TAX1BP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TAX1BP3 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TAX1BP3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TAX1BP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TAX1BP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TAX1BP3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TAX1BP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TAX1BP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TAX1BP3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TAX1BP3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TAX1BP3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TAX1BP3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TAX1BP3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TAX1BP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TAX1BP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TAX1BP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TAX1BP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TAX1BP3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TAX1BP3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TAX1BP3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing TAX1BP3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of TAX1BP3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with TAX1BP3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing TAX1BP3 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of TAX1BP3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of TAX1BP3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.