TBL1X Gene

HGNC Family	WD repeat domain containing (WDR)
Name	transducin (beta)-like 1X-linked
Description	The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTransducin beta‐like protein 1 (TBL1X) functions as an essential adaptor within nuclear protein complexes that regulate transcription. It is required for the recruitment and stabilization of key transcription factors such as β‐catenin to their target gene promoters during Wnt signaling, thereby facilitating the removal of corepressor complexes and oncogenic gene activation. In addition, TBL1X, along with its homolog TBLR1, is a critical component of corepressor complexes involved in unliganded thyroid hormone receptor‐mediated transcriptional repression. Its ability to preferentially bind hypoacetylated histones ensures the stable association of these complexes with chromatin, and features within its LisH domain govern its oligomerization and nuclear localization. Moreover, mutations in the LisH domain can disrupt TBL1X nuclear import, underscoring its importance in maintaining proper transcriptional control and endocrine function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its nuclear roles in transcription regulation, TBL1X has emerged as a pivotal regulator in oncogenic signaling pathways. In multiple cancer types, including pancreatic ductal adenocarcinoma and diffuse large B‐cell lymphoma, aberrant TBL1X expression promotes cellular proliferation, metabolic reprogramming, and invasive behavior. Post‐translational modifications such as SUMOylation further enhance its interaction with NF‐κB and other signaling components, thereby amplifying proinflammatory cytokine production and oncogenic transcriptional programs. Moreover, recent studies indicate that dysregulated TBL1X contributes to immune evasion by mediating the ubiquitination and degradation of tumor suppressor proteins such as TP53—a mechanism that can be driven by long non‐coding RNAs. TBL1X is also implicated in gestational diabetes mellitus, highlighting its broader role in cellular homeostasis and disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ho-Geun Yoon, Youngsok Choi, Philip A Cole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reading and function of a histone code involved in targeting corepressor complexes for repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.1.324-335.2005"}], "href": "https://doi.org/10.1128/MCB.25.1.324-335.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15601853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15601853"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gabi Gerlitz, Enbal Darhin, Giovanna Giorgio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.4.11.2151"}], "href": "https://doi.org/10.4161/cc.4.11.2151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16258276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16258276"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiong Li, Cun-Yu Wang "}, {"type": "b", "children": [{"type": "t", "text": "TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1684"}], "href": "https://doi.org/10.1038/ncb1684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18193033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18193033"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Charlotte A Heinen, Monique Losekoot, Yu Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in TBL1X Are Associated With Central Hypothyroidism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2016-2531"}], "href": "https://doi.org/10.1210/jc.2016-2531"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27603907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27603907"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Valdeko Kruusvee, Matthew J Lyst, Ceitidh Taylor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1700731114"}], "href": "https://doi.org/10.1073/pnas.1700731114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28348241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28348241"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Christian Stoy, Aishwarya Sundaram, Marcos Rios Garcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201404837"}], "href": "https://doi.org/10.15252/emmm.201404837"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26070712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26070712"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Soo-Yeon Park, Younghwa Na, Mee-Hee Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9002"}], "href": "https://doi.org/10.18632/oncotarget.9002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27129164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27129164"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rong Ding, Fei Guo, Yong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated Transcriptome Sequencing Analysis Reveals Role of miR-138-5p/ TBL1X in Placenta from Gestational Diabetes Mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000495319"}], "href": "https://doi.org/10.1159/000495319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30463081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30463081"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Youssef Youssef, Vrajesh Karkhanis, Wing Keung Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2020.268235"}], "href": "https://doi.org/10.3324/haematol.2020.268235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33054136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33054136"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Betsy A Pray, Youssef Youssef, Lapo Alinari "}, {"type": "b", "children": [{"type": "t", "text": "TBL1X: At the crossroads of transcriptional and posttranscriptional regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Hematol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exphem.2022.09.006"}], "href": "https://doi.org/10.1016/j.exphem.2022.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36206873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36206873"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zheng Gong, Huijing Zhang, Yuntian Ge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA MIAT regulates TP53 ubiquitination and expedites prostate adenocarcinoma progression by recruiting TBL1X."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2023.119527"}], "href": "https://doi.org/10.1016/j.bbamcr.2023.119527"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37356458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37356458"}]}]}]}
Synonyms	SMAP55, EBI
Proteins	TBL1X_HUMAN
NCBI Gene ID	6907
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TBL1X has 13,014 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.

Click the + buttons to view associations for TBL1X from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TBL1X Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TBL1X gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TBL1X gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TBL1X gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TBL1X gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TBL1X gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TBL1X gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TBL1X gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TBL1X gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TBL1X gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TBL1X gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TBL1X gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TBL1X gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TBL1X protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TBL1X gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TBL1X gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TBL1X gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TBL1X gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TBL1X gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of TBL1X gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TBL1X protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TBL1X gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TBL1X protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TBL1X protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TBL1X protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TBL1X protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TBL1X protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TBL1X gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TBL1X gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TBL1X gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TBL1X gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TBL1X gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TBL1X gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for TBL1X protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TBL1X gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TBL1X gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TBL1X gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TBL1X gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TBL1X gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TBL1X gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TBL1X gene from the ENCODE Transcription Factor Binding Site Profiles dataset.