{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThromboxane A₂ receptor (TBXA₂R) is a classical G protein–coupled receptor that transduces the actions of its endogenous ligand, thromboxane A₂, by orchestrating complex intracellular signaling. In platelets and other cell types, TBXA₂R activation by agonists such as U46619 induces biphasic secretion and aggregation responses that are mediated through PI3‐kinase–dependent pathways and require integrin “outside–in” signaling. In addition, structural studies and 3D modeling have revealed that key extracellular loop domains and post‐translational modifications (for example, palmitoylation) as well as receptor heterodimerization with partner prostanoid receptors modulate ligand binding and downstream signaling events. These regulatory mechanisms are further refined by isoform‐specific intracellular interactions (e.g. Rab11 and nm23‐H2) that govern receptor trafficking and recycling, thereby tuning the cell’s responsiveness to thromboxane A₂ stimulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in platelets, TBXA₂R critically regulates vascular tone and cellular proliferation. Receptor activation in vascular smooth muscle cells triggers RhoA/ROCK‐ and ion channel–mediated pathways that contribute to vasoconstriction and influence protein synthesis via reactive oxygen species and AMPK activation. In tumor cells—including those of lung and prostate origin—TBXA₂R stimulation drives proliferative and migratory responses through induction of transcription factors (such as Nurr1) and up‐regulation of growth factors like VEGF; this, in turn, promotes invasion, macrophage recruitment and reorganization of the cytoskeleton. Moreover, in endothelial cells, TBXA₂R activation may counteract pro‐angiogenic signals by impairing growth factor receptor internalization and by stimulating the release of anti‐angiogenic mediators, thereby modulating neovascularization in both physiological and pathophysiological settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic variations and post‐translational modifications of TBXA₂R further diversify its functions in health and disease. Several studies have associated specific TBXA₂R polymorphisms with altered platelet reactivity, aspirin‐intolerant and atopic respiratory conditions, as well as increased cardiovascular risk. In addition, differential promoter usage directs the production of distinct receptor isoforms with unique signaling and trafficking properties in various tissues—from megakaryocytes to vascular endothelium—thereby influencing clinical phenotypes in thrombotic, inflammatory and allergic disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhenyu Li, Guoying Zhang, Guy C Le Breton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301838200"}], "href": "https://doi.org/10.1074/jbc.M301838200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12796499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12796499"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kuo-Chen Chou "}, {"type": "b", "children": [{"type": "t", "text": "Coupling interaction between thromboxane A2 receptor and alpha-13 subunit of guanine nucleotide-binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/pr050145a"}], "href": "https://doi.org/10.1021/pr050145a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16212421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16212421"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Stephen J Wilson, Aoife M Roche, Ekaterina Kostetskaia, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M503438200"}], "href": "https://doi.org/10.1074/jbc.M503438200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16126723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16126723"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Moulay Driss Rochdi, Geneviève Laroche, Emilie Dupré, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mapping of a ligand-binding site for the human thromboxane A2 receptor protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M105872200"}], "href": "https://doi.org/10.1074/jbc.M105872200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11877412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11877412"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ke-He Ruan, Jiaxin Wu, Shui-Ping So, et al. 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Modulation of G protein: effector coupling and modes of receptor internalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2006.12.001"}], "href": "https://doi.org/10.1016/j.cellsig.2006.12.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17229546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17229546"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Miao Zhang, Yunzhou Dong, Jian Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.107.163253"}], "href": "https://doi.org/10.1161/CIRCRESAHA.107.163253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18063812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18063812"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Katarina Wikström, David J Kavanagh, Helen M Reid, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential regulation of RhoA-mediated signaling by the TPalpha and TPbeta isoforms of the human thromboxane A2 receptor: independent modulation of TPalpha signaling by prostacyclin and nitric oxide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2008.04.006"}], "href": "https://doi.org/10.1016/j.cellsig.2008.04.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18502100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18502100"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Min Li, Yoshio Tanaka, Abderrahmane Alioua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1002685107"}], "href": "https://doi.org/10.1073/pnas.1002685107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20959415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20959415"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiuling Li, Hsin-Hsiung Tai "}, {"type": "b", "children": [{"type": "t", "text": "Activation of thromboxane A(2) receptors induces orphan nuclear receptor Nurr1 expression and stimulates cell proliferation in human lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgp161"}], "href": "https://doi.org/10.1093/carcin/bgp161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19570744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19570744"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Daotai Nie, Yande Guo, Dianer Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-1018"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-1018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18172303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18172303"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xiuling Li, Hsin-Hsiung Tai "}, {"type": "b", "children": [{"type": "t", "text": "Activation of thromboxane A2 receptor (TP) increases the expression of monocyte chemoattractant protein -1 (MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) and recruits macrophages to promote invasion of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0054073"}], "href": "https://doi.org/10.1371/journal.pone.0054073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23349788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23349788"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jingyan Wei, Weili Yan, Xiuling Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thromboxane receptor alpha mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lung Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lungcan.2009.09.009"}], "href": "https://doi.org/10.1016/j.lungcan.2009.09.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19853959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19853959"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Laurent Colombe, Jean-François Michelet, Bruno Alain Bernard "}, {"type": "b", "children": [{"type": "t", "text": "Prostanoid receptors in anagen human hair follicles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0625.2007.00639.x"}], "href": "https://doi.org/10.1111/j.1600-0625.2007.00639.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18005048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18005048"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Anthony W Ashton, Yan Cheng, Armin Helisch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000122043.11286.57"}], "href": "https://doi.org/10.1161/01.RES.0000122043.11286.57"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14963009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14963009"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Anthony W Ashton, J Anthony Ware "}, {"type": "b", "children": [{"type": "t", "text": "Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000138300.41642.15"}], "href": "https://doi.org/10.1161/01.RES.0000138300.41642.15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15242977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15242977"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ralf A Benndorf, Edzard Schwedhelm, Anke Gnann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.108.184036"}], "href": "https://doi.org/10.1161/CIRCRESAHA.108.184036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18802021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18802021"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Fei Gao, Heidi Y Shi, Cathy Daughty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maspin plays an essential role in early embryonic development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.01048"}], "href": "https://doi.org/10.1242/dev.01048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14985257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14985257"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "S-H Kim, J-H Choi, H-S Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Allergy (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2222.2005.02220.x"}], "href": "https://doi.org/10.1111/j.1365-2222.2005.02220.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15898979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15898979"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Sang-Heon Kim, Yoon-Keun Kim, Heung-Woo Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.fpc.0000239977.61841.fe"}], "href": "https://doi.org/10.1097/01.fpc.0000239977.61841.fe"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17496729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17496729"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Seung-Hyun Kim, Young-Min Ye, Gyu Young Hur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/14622416.8.9.1143"}], "href": "https://doi.org/10.2217/14622416.8.9.1143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17924829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17924829"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Andrew D Mumford, Ban B Dawood, Martina E Daly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-08-236976"}], "href": "https://doi.org/10.1182/blood-2009-08-236976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19828703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19828703"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Keiko Tanaka, Mark H Roberts, Naoko Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants of the receptors for thromboxane A2 and IL-4 in atopic dermatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/bbrc.2002.6713"}], "href": "https://doi.org/10.1006/bbrc.2002.6713"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11922633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11922633"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Soo-Jong Hong, So-Yeon Lee, Hyo-Bin Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2004.10.047"}], "href": "https://doi.org/10.1016/j.jaci.2004.10.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15805995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15805995"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "J-H Kim, S-Y Lee, H-B Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBXA2R gene polymorphism and responsiveness to leukotriene receptor antagonist in children with asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Allergy (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2222.2007.02874.x"}], "href": "https://doi.org/10.1111/j.1365-2222.2007.02874.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18031559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18031559"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Pierre Fontana, Sophie Gandrille, Véronique Remones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thromb Haemost (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1160/TH06-05-0288"}], "href": "https://doi.org/10.1160/TH06-05-0288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16953279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16953279"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "N S Palikhe, S-H Kim, H-Y Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of thromboxane A2 receptor (TBXA2R) gene polymorphism in patients with aspirin-intolerant acute urticaria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Allergy (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2222.2010.03642.x"}], "href": "https://doi.org/10.1111/j.1365-2222.2010.03642.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21070398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21070398"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Adrian T Coyle, Sinead M Miggin, B Therese Kinsella "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the 5' untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP). Differential promoter utilization by the TP isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Biochem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1432-1033.2002.03098.x"}], "href": "https://doi.org/10.1046/j.1432-1033.2002.03098.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12180983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12180983"}]}]}]}