{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nBreast cancer is a complex and prevalent malignancy driven by diverse genetic and epigenetic factors. Long non‐coding RNAs (lncRNAs) have emerged as crucial regulators in cancer progression, with TDRKH‑AS1 being one such lncRNA that has been implicated in several cancer types. However, its specific function in breast cancer remains to be fully elucidated, leaving open questions regarding its potential role in modulating cellular pathways associated with tumor growth and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Early evidence hints that TDRKH‑AS1 may act as a regulatory molecule contributing to oncogenic processes, possibly by influencing gene expression networks and interacting with key molecular partners involved in tumor progression. Despite these suggestions, the detailed molecular mechanisms and biological outcomes of TDRKH‑AS1 activity, particularly in the context of breast cancer, continue to be subjects for further investigation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In summary, while TDRKH‑AS1 is recognized for its association with various malignancies, its functional role in breast cancer is still unclear. Future studies aimed at delineating how TDRKH‑AS1 integrates into cancer-related signaling pathways could reveal novel insights into breast cancer pathogenesis and potentially pave the way for new diagnostic and therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuqin Ding, Yuting Huang, Fanrong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TDRKH-AS1 promotes breast cancer progression via the miR-134-5p/CREB1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-023-04640-3"}], "href": "https://doi.org/10.1186/s12967-023-04640-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38008726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38008726"}]}]}]}