| Name | terminal nucleotidyltransferase 4A |
| Description | The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTENT4A (also known as PAPD7) is a non‐canonical poly(A) polymerase that diversifies the composition of 3′ RNA tails by incorporating non‐adenosine nucleotides—most notably guanosine—into poly(A) tails. This “mixed tailing” shields messenger RNAs from rapid deadenylation and decay, thereby fine‐tuning mRNA stability and translation. Moreover, characterization of its active isoform (PAPD7 l) has revealed the requirement for a specific region that supports its robust nucleotidyl transferase activity and governs its nuclear retention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn viral contexts, TENT4A forms part of a regulatory complex that modifies the 3′ ends of viral transcripts. In association with proteins such as ZCCHC14, TENT4A catalyzes mixed tailing on hepatitis B and cytomegalovirus RNAs—and even plays a critical role in hepatitis A virus RNA synthesis—by recognizing conserved RNA structural elements. Such activities not only stabilize viral mRNAs against deadenylation but also influence viral RNA production, highlighting TENT4A’s potential as a target for antiviral intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in RNA tail modulation, chemical inhibition of the TENT4 family has been shown to rescue telomerase function in disease settings. In models of telomere biology disorders, for example, treatment with a PAPD5/7 inhibitor restored telomerase RNA (TERC) levels, corrected telomerase localization, and promoted telomere elongation, underscoring the therapeutic promise of targeting TENT4A activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTENT4A also exerts multilayered control over genome stability by regulating translesion DNA synthesis (TLS). It modulates the mRNA stability and translation of key TLS components—such as RAD18 and DNA polymerase η—as well as indirectly influencing these factors through regulators like CYLD and non‐coding antisense RNAs. This posttranscriptional control links its RNA tailing activity to the maintenance of genomic integrity during the DNA damage response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Koichi Ogami, Rihe Cho, Shin-ichi Hoshino "}, {"type": "b", "children": [{"type": "t", "text": "Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.01.072"}], "href": "https://doi.org/10.1016/j.bbrc.2013.01.072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23376078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23376078"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jaechul Lim, Dongwan Kim, Young-Suk Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aam5794"}], "href": "https://doi.org/10.1126/science.aam5794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30026317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30026317"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dongwan Kim, Young-Suk Lee, Soo-Jin Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-020-0427-3"}], "href": "https://doi.org/10.1038/s41594-020-0427-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32451488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32451488"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "You Li, Ichiro Misumi, Tomoyuki Shiota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2204511119"}], "href": "https://doi.org/10.1073/pnas.2204511119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35867748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35867748"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Siddharth Shukla, Ho-Chang Jeong, Christopher M Sturgeon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2020001848"}], "href": "https://doi.org/10.1182/bloodadvances.2020001848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32559291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32559291"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Umakanta Swain, Gilgi Friedlander, Urmila Sehrawat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22136957"}], "href": "https://doi.org/10.3390/ijms22136957"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34203408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34203408"}]}]}]}
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| NCBI Gene ID | 11044 |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TENT4A has 3,340 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 44 datasets.
Click the + buttons to view associations for TENT4A from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TENT4A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of TENT4A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with TENT4A protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with TENT4A gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of TENT4A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI U2OS Cell Map Protein Localization Assemblies | assemblies containing TENT4A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing TENT4A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing TENT4A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TENT4A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of TENT4A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by TENT4A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TENT4A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving TENT4A gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving TENT4A gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing TENT4A protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing TENT4A protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by TENT4A gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by TENT4A gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of TENT4A gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TENT4A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of TENT4A gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with TENT4A gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by TENT4A gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TENT4A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of TENT4A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| KEGG Pathways 2026 | pathways involving TENT4A protein from the KEGG Pathways 2026 dataset. | |
| Kinase Library Tyrosine Kinome Atlas | kinases that phosphorylate TENT4A protein from the Kinase Library Tyrosine Kinome Atlas dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of TENT4A gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of TENT4A gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by TENT4A gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of TENT4A gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of TENT4A gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving TENT4A protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| Reactome Pathways 2024 | pathways involving TENT4A protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of TENT4A gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of TENT4A gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of TENT4A gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TENT4A gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TENT4A gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of TENT4A gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of TENT4A gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TENT4A protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TENT4A protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TENT4A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
