| Name | terminal nucleotidyltransferase 4B |
| Description | Enables guanylyltransferase activity; poly(A) RNA polymerase activity; and telomerase RNA binding activity. Involved in RNA metabolic process; carbohydrate homeostasis; and regulation of nucleobase-containing compound metabolic process. Located in cytosol; nucleolus; and plasma membrane. Part of TRAMP complex. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTENT4B (also known as PAPD5) is a noncanonical poly(A) polymerase that plays dual roles in posttranscriptional RNA regulation. In one context, it catalyzes the addition of nontemplated nucleotides—including adenosines and guanosines—to RNA 3′ ends. Such mixed tailing can mark RNAs for degradation, as seen in the polyadenylation‐dependent turnover of oncogenic miRNAs, while in other contexts the incorporation of intermittent guanosine residues impedes deadenylase activity and protects mRNA from rapid decay."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its impact on mRNA stability, TENT4B is also critical to RNA quality control and maturation processes. Its polymerase activity is involved in processing aberrant pre‐rRNAs and histone mRNAs, and it influences the fate of noncoding RNAs such as the human telomerase RNA (hTR). In disease contexts like dyskeratosis congenita, the aberrant oligoadenylation of hTR by TENT4B accelerates RNA degradation, whereas inhibition or genetic silencing of its activity can restore hTR levels and telomerase function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn viral infections, TENT4B functions within a larger complex involving RNA-binding partners (such as ZCCHC14) to generate protective mixed tails on viral transcripts. This activity is pivotal for sustaining viral RNA synthesis and stability in hepatitis viruses, with studies showing that inhibition of TENT4B (often together with its paralog TENT4A) can markedly suppress viral replication and ameliorate liver pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christiane Rammelt, Biter Bilen, Mihaela Zavolan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.2787011"}], "href": "https://doi.org/10.1261/rna.2787011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21788334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21788334"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Joost Boele, Helena Persson, Jay W Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1317751111"}], "href": "https://doi.org/10.1073/pnas.1317751111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25049417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25049417"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jaechul Lim, Dongwan Kim, Young-Suk Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aam5794"}], "href": "https://doi.org/10.1126/science.aam5794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30026317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30026317"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Haruka Sudo, Aya Nozaki, Hideaki Uno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction properties of human TRAMP-like proteins and their role in pre-rRNA 5'ETS turnover."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.12314"}], "href": "https://doi.org/10.1002/1873-3468.12314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27434818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27434818"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Caitlin M Roake, Lu Chen, Ananya L Chakravarthy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2019.02.033"}], "href": "https://doi.org/10.1016/j.molcel.2019.02.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30930056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30930056"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Siddharth Shukla, Ho-Chang Jeong, Christopher M Sturgeon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2020001848"}], "href": "https://doi.org/10.1182/bloodadvances.2020001848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32559291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32559291"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dongwan Kim, Young-Suk Lee, Soo-Jin Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-020-0427-3"}], "href": "https://doi.org/10.1038/s41594-020-0427-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32451488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32451488"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "You Li, Ichiro Misumi, Tomoyuki Shiota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2204511119"}], "href": "https://doi.org/10.1073/pnas.2204511119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35867748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35867748"}]}]}]}
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| NCBI Gene ID | 64282 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TENT4B has 1,469 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 39 datasets.
Click the + buttons to view associations for TENT4B from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TENT4B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with TENT4B protein from the CCLE Cell Line Proteomics dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of TENT4B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of TENT4B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing TENT4B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing TENT4B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with TENT4B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of TENT4B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by TENT4B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with TENT4B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with TENT4B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with TENT4B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with TENT4B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving TENT4B gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving TENT4B gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing TENT4B protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing TENT4B protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by TENT4B gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by TENT4B gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of TENT4B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with TENT4B gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of TENT4B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of TENT4B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| KEGG Pathways 2026 | pathways involving TENT4B protein from the KEGG Pathways 2026 dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of TENT4B gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of TENT4B gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving TENT4B protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of TENT4B gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of TENT4B gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of TENT4B gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of TENT4B gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of TENT4B gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of TENT4B gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of TENT4B gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of TENT4B gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TENT4B protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of TENT4B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with TENT4B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving TENT4B protein from the WikiPathways Pathways 2024 dataset. | |
