{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nFAM46B, also known as TENT5B, has been implicated as a regulator of cell growth in prostate cancer. In this context, FAM46B expression is reduced in tumor tissues compared to normal cells, and its loss leads to enhanced cell cycle progression and proliferation via stabilization of β‐catenin protein levels. Mechanistically, FAM46B promotes the ubiquitination and degradation of β‐catenin, thus acting as a tumor suppressor by tempering proliferative signals in prostate cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \n \nFAM46B is also recognized as a non-canonical poly(A) polymerase with a unique architecture that resembles prokaryotic PAP/CCA-adding enzymes. It possesses an enlarged N-terminal catalytic domain and a C-terminal helical domain, features that underpin its ability to preferentially add polyadenine tails to adenosine-rich RNAs. This activity is crucial for maintaining translational efficiency in human pre-implantation embryos and pluripotent stem cells, with its expression being indispensable for cell viability; its depletion leads to apoptosis and impaired protein synthesis, highlighting an essential role in early embryonic development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Liang, Xuxiao Ye, Yuanyuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM46B inhibits cell proliferation and cell cycle progression in prostate cancer through ubiquitination of β-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-018-0184-0"}], "href": "https://doi.org/10.1038/s12276-018-0184-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30532005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30532005"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jia-Li Hu, He Liang, Hong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkaa049"}], "href": "https://doi.org/10.1093/nar/gkaa049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32009146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32009146"}]}]}]}