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In so doing, it efficiently suppresses aberrant repair events—such as nonhomologous end joining—and preserves functional, capped telomeres even when telomere shortening occurs or after replication stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in end‐capping, TRF2 coordinates a network of protein–protein and protein–DNA interactions that dictate telomere architecture and facilitate replication. It directly associates with other core shelterin components (such as RAP1 and TIN2) and recruits accessory factors—including DNA repair helicases like WRN, RTEL1, and structure‐specific nucleases such as Apollo—to manage replication stress, resolve stalled forks, and promote proper t‐loop disassembly when necessary. 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TRF2 also exerts control on non‐telomeric chromatin by binding interstitial telomeric sequences and modulating gene transcription, with perturbations in its levels or activity being linked to genomic instability, altered cytokine responses, angiogenesis, and cancer progression. 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