| Name | testis expressed 41 (non-protein coding) |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn skin cutaneous melanoma (SKCM), the enhancer RNA TEX41 is markedly overexpressed in tumor specimens compared with normal skin, and its elevated expression is associated with poorer overall survival. TEX41 also correlates with alterations in several tumor‐infiltrating immune cell populations and is linked to key signaling pathways such as transcriptional misregulation in cancer and melanogenesis, suggesting its utility as both a prognostic biomarker and a potential therapeutic target in SKCM."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In renal cell carcinoma (RCC), WTAP—a methyltransferase—upregulates the m6A modification of the long noncoding RNA TEX41, leading to its destabilization in a YTHDF2-dependent manner. Despite this destabilization, TEX41 interacts with the SUZ12 protein to enhance its histone methyltransferase activity, ultimately resulting in the silencing of HDAC1. This WTAP/TEX41/SUZ12/HDAC1 axis drives RCC cell proliferation and metastasis, underscoring the oncogenic role of TEX41 in RCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "In squamous cell carcinoma (SCC), TEX41 expression is significantly increased and contributes to tumor progression by modulating the miR-153-3p/Atg5 regulatory pathway. Acting as a competing endogenous RNA, TEX41 sequesters miR-153-3p, which leads to an upregulation of Atg5 and thereby enhances SCC cell proliferation and migration. These findings position TEX41 as a key mediator in SCC and a promising candidate for targeted therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhi-Yong Chen, Jie-Qing Huang, Yu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/2409820"}], "href": "https://doi.org/10.1155/2021/2409820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34795805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34795805"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhenwei Zhou, Xianjiong Chen, Huan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WTAP-dependent N6-methyladenosine methylation of lncRNA TEX41 promotes renal cell carcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-76326-9"}], "href": "https://doi.org/10.1038/s41598-024-76326-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39433619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39433619"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenbo Yang, Yuyou Chen "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TEX41 promotes the proliferation and migration of squamous cell carcinoma cells by upregulating Atg5 via sponging miR-153-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2023.69.14.42"}], "href": "https://doi.org/10.14715/cmb/2023.69.14.42"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38279424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38279424"}]}]}]}
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| Synonyms | LINC00953, DKFZP686O1327 |
| NCBI Gene ID | 401014 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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TEX41 has 1,303 functional associations with biological entities spanning 6 categories (molecular profile, chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 29 datasets.
Click the + buttons to view associations for TEX41 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of TEX41 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of TEX41 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of TEX41 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of TEX41 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TEX41 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of TEX41 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TEX41 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of TEX41 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| dbGAP Gene-Trait Associations | traits associated with TEX41 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TEX41 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of TEX41 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of TEX41 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of TEX41 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of TEX41 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of TEX41 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of TEX41 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of TEX41 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of TEX41 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with TEX41 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with TEX41 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with TEX41 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with TEX41 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of TEX41 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of TEX41 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of TEX41 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain TEX41 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of TEX41 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of TEX41 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at TEX41 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
