TGM1 Gene

HGNC Family	Transglutaminases (TGM)
Name	transglutaminase 1
Description	The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTransglutaminase‑1 (TGase‑1), encoded by TGM1, is a Ca²⁺‑dependent enzyme that catalyzes the formation of ε‑(γ‑glutamyl)–lysine cross‑links between structural proteins. In the epidermis this cross‑linking activity is essential for assembling the robust cornified cell envelope during terminal keratinocyte differentiation, thereby ensuring an effective barrier against water loss and environmental insults. Mutations in TGM1 are the principal cause of several autosomal recessive congenital ichthyoses—including lamellar ichthyosis, congenital ichthyosiform erythroderma, self‑healing collodion ichthyosis, and bathing suit ichthyosis—where defective enzyme function disrupts envelope formation, alters retinoid‑regulated pathways (for example via TIG3) and induces compensatory innate defense responses in the skin."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its cutaneous role, TGase‑1 is also expressed in other epithelial tissues. For example, immunohistochemical analyses reveal TGase‑1 activity in normal bronchial epithelium and in preinvasive lesions—suggesting a role in squamous differentiation—while studies in hair roots indicate that its deficiency may contribute to abnormal appendage formation. In addition, the enzyme has been implicated in age‑related protein polymerization events, such as the generation of corpora amylacea in the brain."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its physiological role in differentiation, TGase‑1 can contribute to pathological protein cross‑linking. Experimental data indicate that, alongside other transglutaminases, TGase‑1 is capable of cross‑linking aggregation‑prone proteins—thereby potentially contributing to the formation of insoluble inclusions seen in neurodegenerative diseases such as Huntington’s and Alzheimer’s diseases. Furthermore, aberrant TGM1 expression has been observed in certain cancers (for instance, gastric cancer), where its up‑regulation correlates with increased cell proliferation, enhanced “stemness” and activation of pathways such as Wnt signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael T Sturniolo, Shervin R Dashti, Anne Deucher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307215200"}], "href": "https://doi.org/10.1074/jbc.M307215200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12928434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12928434"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Robert H Rice, Debra Crumrine, Yoshikazu Uchida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Dermatol Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00403-005-0591-7"}], "href": "https://doi.org/10.1007/s00403-005-0591-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16133457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16133457"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Clara De Pascale, Anna Maria Bassi, Vania Patrone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of transglutaminase-1 and PPARgamma after vitamin E treatment in human keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2006.02.002"}], "href": "https://doi.org/10.1016/j.abb.2006.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16530159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16530159"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "S Farasat, M-H Wei, M Herman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel transglutaminase-1 mutations and genotype-phenotype investigations of 104 patients with autosomal recessive congenital ichthyosis in the USA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2008.060905"}], "href": "https://doi.org/10.1136/jmg.2008.060905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18948357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18948357"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Matthew L Herman, Sharifeh Farasat, Peter J Steinbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20952"}], "href": "https://doi.org/10.1002/humu.20952"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19241467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19241467"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Anders Vahlquist, Anette Bygum, Agneta Gånemo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2009.346"}], "href": "https://doi.org/10.1038/jid.2009.346"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19890349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19890349"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Laura Fachal, Laura Rodríguez-Pazos, Manuel Ginarte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple local and recent founder effects of TGM1 in Spanish families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0033580"}], "href": "https://doi.org/10.1371/journal.pone.0033580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22511925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22511925"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hao Li, Elizabeth P Loriè, Judith Fischer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of epidermal lipoxygenases and transglutaminase-1 is perturbed by NIPAL4 mutations: indications of a common metabolic pathway essential for skin barrier homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2012.160"}], "href": "https://doi.org/10.1038/jid.2012.160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22622417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22622417"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Emmanuelle Bourrat, Claudine Blanchet-Bardon, Celine Derbois, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific TGM1 mutation profiles in bathing suit and self-improving collodion ichthyoses: phenotypic and genotypic data from 9 patients with dynamic phenotypes of autosomal recessive congenital ichthyosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Dermatol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/archdermatol.2012.1947"}], "href": "https://doi.org/10.1001/archdermatol.2012.1947"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22801880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22801880"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "A Terrinoni, V Serra, A Codispoti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel transglutaminase 1 mutations in patients affected by lamellar ichthyosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2012.152"}], "href": "https://doi.org/10.1038/cddis.2012.152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23096117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23096117"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hao Li, Anders Vahlquist, Hans Törmä "}, {"type": "b", "children": [{"type": "t", "text": "Interactions between FATP4 and ichthyin in epidermal lipid processing may provide clues to the pathogenesis of autosomal recessive congenital ichthyosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dermatol Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jdermsci.2012.11.593"}], "href": "https://doi.org/10.1016/j.jdermsci.2012.11.593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23290633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23290633"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Takashi Haneda, Yasutomo Imai, Ryosuke Uchiyama, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "In vivo transglutaminase type 1 expression in normal lung, preinvasive bronchial lesions, and lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2002-0114OC"}], "href": "https://doi.org/10.1165/rcmb.2002-0114OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12654631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12654631"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Michael Raghunath, Lambrini Tontsidou, Vinzenz Oji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPINK5 and Netherton syndrome: novel mutations, demonstration of missing LEKTI, and differential expression of transglutaminases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.0022-202X.2004.23220.x"}], "href": "https://doi.org/10.1111/j.0022-202X.2004.23220.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15304086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15304086"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Eric V Marietta, Michael J Camilleri, Luis A Castro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.jid.5701041"}], "href": "https://doi.org/10.1038/sj.jid.5701041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17762854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17762854"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Micha M M Wilhelmus, Robin Verhaar, John G J M Bol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel role of transglutaminase 1 in corpora amylacea formation?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2009.04.019"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2009.04.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19464759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19464759"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Gina M Zainelli, Nichole L Dudek, Christopher A Ross, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1750-3639.2008.00197.x"}], "href": "https://doi.org/10.1111/j.1750-3639.2008.00197.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18673368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18673368"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Haitao Huang, Zhiqi Chen, Xiuqin Ni "}, {"type": "b", "children": [{"type": "t", "text": "Tissue transglutaminase-1 promotes stemness and chemoresistance in gastric cancer cells by regulating Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Biol Med (Maywood) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1535370216670541"}], "href": "https://doi.org/10.1177/1535370216670541"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27660242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27660242"}]}]}]}
Synonyms	TGK, KTG, ICR2, ARCI1, LI1, LI, TGASE
Proteins	TGM1_HUMAN
NCBI Gene ID	7051
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TGM1 has 6,901 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for TGM1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TGM1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TGM1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TGM1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TGM1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TGM1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TGM1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TGM1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TGM1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TGM1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TGM1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TGM1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TGM1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TGM1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TGM1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TGM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TGM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TGM1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TGM1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TGM1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TGM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TGM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing TGM1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TGM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TGM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TGM1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TGM1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TGM1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TGM1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with TGM1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by TGM1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TGM1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TGM1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TGM1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TGM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TGM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TGM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TGM1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for TGM1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TGM1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TGM1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TGM1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.