{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTHOC7‐AS1 is a long noncoding RNA that has been found to be frequently upregulated in cutaneous squamous cell carcinoma (cSCC), alongside increased expression of FSTL1, suggesting a potential role in the tumor’s biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the specific molecular mechanisms by which THOC7‐AS1 contributes to cSCC pathogenesis remain poorly defined, its consistent overexpression points to a possible involvement in regulating gene expression or cellular processes that promote tumor growth and progression.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGiven the emerging association between THOC7‐AS1 and cSCC, there is considerable interest in exploring its function further to determine whether it might impact critical signaling pathways or interact with key regulatory molecules within the carcinoma. Understanding these interactions could help reveal important insights into the underlying mechanisms of tumor development and resistance, thereby advancing our knowledge of cSCC biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, due to its frequent upregulation in tumor samples, THOC7‐AS1 is being considered as a promising candidate for therapeutic targeting. Further research into its molecular functions might not only clarify its role in the progression of cSCC but also provide a foundation for the development of novel, lncRNA‐based diagnostic and treatment strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Site Yu, Xu Cui, Situo Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-024-05116-8"}], "href": "https://doi.org/10.1186/s12967-024-05116-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38605354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38605354"}]}]}]}