{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNAs have emerged as pivotal regulators in a variety of pathological conditions. In osteoarthritis, THUMPD3‑AS1, also known as THUMPD3 antisense RNA 1, has been implicated in modulating disease development though its precise mechanisms remain under investigation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, studies in colorectal cancer have employed ceRNA network analyses to elucidate how noncoding RNAs contribute to tumorigenesis, highlighting the broader relevance of ceRNA-mediated regulation in malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, THUMPD3‑AS1 expression is significantly reduced in tumor tissues compared with normal counterparts. Downregulation of THUMPD3‑AS1 is associated with advanced TNM stage, lymphatic and vascular infiltration, and poorer overall survival. Functionally, overexpression of THUMPD3‑AS1 inhibits cell proliferation, migration, and invasion, and reduces reactive oxygen species accumulation by modulating the miR‑1252‑3p/CXCL17 axis, thereby suggesting a tumor‐suppressive role in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, in ovarian cancer, THUMPD3‑AS1 acts as an oncogenic long noncoding RNA. It is highly expressed in ovarian cancer cells where it functions as a molecular sponge for miR‑320d, preventing miRNA‑mediated degradation of ARF1. The consequent upregulation of ARF1 is linked to enhanced cell viability and reduced apoptosis, underscoring a role for THUMPD3‑AS1 in promoting malignant progression in ovarian cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yingjie Wang, Tian Li, Qi Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA THUMPD3-AS1 enhances the proliferation and inflammatory response of chondrocytes in osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2021.108138"}], "href": "https://doi.org/10.1016/j.intimp.2021.108138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34509934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34509934"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuwei Pu, Jinrong Wei, Yong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "THUMPD3-AS1 facilitates cell growth and aggressiveness by the miR-218-5p/SKAP1 axis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Biophys (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12013-022-01074-4"}], "href": "https://doi.org/10.1007/s12013-022-01074-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35538197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35538197"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuwei Tan, Liang Liu, Xuemei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "THUMPD3-AS1 Is Correlated with Gastric Cancer and Regulates Cell Function through miR-1252-3p and CXCL17."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2022042848"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2022042848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36017917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36017917"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qingling Mu, Xin Wang, Kui Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the miR-320d/ARF1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202302475RRR"}], "href": "https://doi.org/10.1096/fj.202302475RRR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38963337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38963337"}]}]}]}