TINF2 Gene

Name	TERF1 (TRF1)-interacting nuclear factor 2
Description	This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTIN2, encoded by TINF2, is a central component of the shelterin complex that safeguards telomere integrity by serving as a critical bridging factor. It directly binds to the double‐stranded telomeric proteins TRF1 and TRF2 while simultaneously interacting with TPP1 and POT1, thereby promoting a stable assembly that regulates telomere length and conformation. In vitro studies have demonstrated that TIN2 promotes higher order telomeric DNA interactions, effectively clustering telomeric tracts, and modulates enzymatic regulators such as tankyrase that otherwise antagonize TRF1’s binding to telomeres."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPathogenic mutations in TINF2 have been identified in patients with dyskeratosis congenita (DC) and related telomere biology disorders. These mutations frequently occur in a critical region of TINF2 and are associated with very short telomeres, reflecting impaired shelterin complex function. In cellular models, TINF2 mutations compromise the recruitment of telomerase to the telomeres without necessarily altering overall telomerase activity, suggesting a defect in telomerase–telomere interactions that accelerates telomere shortening. Moreover, studies in clinical cohorts have correlated severe DC phenotypes and even cases of hematologic and epithelial malignancies with dysregulated expression or defective bridging functions of the TIN2 protein."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its canonical telomeric roles, alternative isoforms and subnuclear localizations of TIN2 have been described, underscoring a dual functionality. One isoform, TIN2L, associates tightly with the nuclear matrix, and differential partitioning of TIN2 into extra‐telomeric domains has been linked to controlled cell proliferation and differentiation. Furthermore, TIN2 is now recognized to stimulate telomerase processivity via its cooperation with the TPP1–POT1 complex, a feature that is critical for proper telomere maintenance. These emerging facets not only deepen our understanding of telomere homeostasis but also highlight how subtle alterations in TIN2’s structure or expression can contribute to genomic instability in diverse pathological settings such as chronic lymphocytic leukemia and hepatocarcinogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sahn-Ho Kim, Seungil Han, Young-Hyun You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.embor872"}], "href": "https://doi.org/10.1038/sj.embor.embor872"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12835755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12835755"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jeffrey Zheng-Sheng Ye, Titia de Lange "}, {"type": "b", "children": [{"type": "t", "text": "TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1360"}], "href": "https://doi.org/10.1038/ng1360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15133513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15133513"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sahn-ho Kim, Christian Beausejour, Albert R Davalos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIN2 mediates functions of TRF2 at human telomeres."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M408650200"}], "href": "https://doi.org/10.1074/jbc.M408650200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15292264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15292264"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jeffrey Zheng-Sheng Ye, Jill R Donigian, Megan van Overbeek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M409047200"}], "href": "https://doi.org/10.1074/jbc.M409047200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15316005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15316005"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bong-Kyeong Oh, Young-Joo Kim, Chanil Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0002-9440(10)62233-X"}], "href": "https://doi.org/10.1016/S0002-9440(10"}, {"type": "t", "text": "62233-X) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15632001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15632001"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Patrick Kaminker, Cedric Plachot, Sahn-Ho Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01709"}], "href": "https://doi.org/10.1242/jcs.01709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15741234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15741234"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Matthew S O'Connor, Amin Safari, Huawei Xin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0605303103"}], "href": "https://doi.org/10.1073/pnas.0605303103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16880378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16880378"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sharon A Savage, Neelam Giri, Gabriela M Baerlocher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2007.10.004"}], "href": "https://doi.org/10.1016/j.ajhg.2007.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18252230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18252230"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Amanda J Walne, Tom Vulliamy, Richard Beswick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-05-153445"}], "href": "https://doi.org/10.1182/blood-2008-05-153445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18669893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18669893"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sahn-Ho Kim, Albert R Davalos, Seok-Jin Heo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200710028"}], "href": "https://doi.org/10.1083/jcb.200710028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18443218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18443218"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Patrick G Kaminker, Sahn-Ho Kim, Pierre-Yves Desprez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.8.6.7941"}], "href": "https://doi.org/10.4161/cc.8.6.7941"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19229133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19229133"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Eladio Abreu, Elena Aritonovska, Patrick Reichenbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00240-10"}], "href": "https://doi.org/10.1128/MCB.00240-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20404094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20404094"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "T de Lange "}, {"type": "b", "children": [{"type": "t", "text": "How shelterin solves the telomere end-protection problem."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cold Spring Harb Symp Quant Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/sqb.2010.75.017"}], "href": "https://doi.org/10.1101/sqb.2010.75.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21209389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21209389"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Adeline Augereau, Claire T'kint de Roodenbeke, Thomas Simonet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-07-295774"}], "href": "https://doi.org/10.1182/blood-2010-07-295774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21355086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21355086"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dong Yang, Quanyuan He, Hyeung Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.225870"}], "href": "https://doi.org/10.1074/jbc.M111.225870"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21536674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21536674"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Amanda K Frank, Duy C Tran, Roy W Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1005410"}], "href": "https://doi.org/10.1371/journal.pgen.1005410"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26230315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26230315"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Alexandra M Pike, Margaret A Strong, John Paul T Ouyang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00593-18"}], "href": "https://doi.org/10.1128/MCB.00593-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31383750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31383750"}]}]}]}
Synonyms	DKCA3, TIN2
Proteins	TINF2_HUMAN
NCBI Gene ID	26277
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

TINF2 has 7,248 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 126 datasets.

Click the + buttons to view associations for TINF2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

TINF2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TINF2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of TINF2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of TINF2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of TINF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of TINF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of TINF2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of TINF2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of TINF2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of TINF2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of TINF2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of TINF2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with TINF2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with TINF2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TINF2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of TINF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of TINF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with TINF2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with TINF2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing TINF2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of TINF2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing TINF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing TINF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with TINF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with TINF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing TINF2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of TINF2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with TINF2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with TINF2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with TINF2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of TINF2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving TINF2 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving TINF2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with TINF2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with TINF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with TINF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with TINF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with TINF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at TINF2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of TINF2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of TINF2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.