{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that the long noncoding RNA, referred to in these works as TIPARP‐AS1 (though originally described as a novel lncRNA or LINC00886), functions predominantly as a tumor suppressor. In laryngeal squamous cell carcinoma, this lncRNA appears to be epigenetically regulated, with DNA methylation and histone modifications contributing to its transcriptional inactivation, which may promote tumor formation and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn esophageal squamous cell carcinoma, down‐regulation of this lncRNA due to promoter hypermethylation and associated histone modifications leads to diminished expression, thereby facilitating malignant transformation. Mechanistically, the lncRNA interferes with cellular proliferation, migration, and invasion, and it participates in the epithelial–mesenchymal transition process by regulating key EMT-related genes. It has been shown to interact with chromatin regulators such as SIRT7 to modify histone acetylation on the promoters of downstream targets like ELF3, which in turn modulates the expression of transcription factors (ZEB1 and ZEB2) and microRNA signals (miR-144) that are critical for maintaining the epithelial phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in anaplastic thyroid cancer, decreased expression of this lncRNA is associated with dedifferentiation and enhanced tumor malignancy. Functional studies have demonstrated that the lncRNA interacts physically with protein kinase R (PKR), stabilizing it and influencing its degradation via the ubiquitin/proteasome pathway. This interaction indirectly modulates the activity of the eukaryotic initiation factor 2α (eIF2α), leading to alterations in protein synthesis that favor cancer cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lili Lan, Huan Cao, Weiwei Chi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant DNA hypermethylation-silenced LINC00886 gene accelerates malignant progression of laryngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2020.152877"}], "href": "https://doi.org/10.1016/j.prp.2020.152877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32111441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32111441"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhiming Dong, Liu Yang, Juntao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of LINC00886 facilitates epithelial-mesenchymal transition through SIRT7/ELF3/miR-144 pathway in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Metastasis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10585-022-10171-w"}], "href": "https://doi.org/10.1007/s10585-022-10171-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35616822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35616822"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ben Ma, Yi Luo, Weibo Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00886 Negatively Regulates Malignancy in Anaplastic Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/endocr/bqac204"}], "href": "https://doi.org/10.1210/endocr/bqac204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36726346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36726346"}]}]}]}